SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment

Noda, Takumi; Kamiya, Kentaro; Hamazaki, Nobuaki; Nozaki, Kohei; Ichikawa, Takafumi; Uchida, Shota; Ueno, Kensuke; Maekawa, Emi; Terada, Tasuku; Reed, Jennifer L.; Yamaoka‐Tojo, Minako; Matsunaga, Atsuhiko; Ako, Junya

doi:10.1016/j.exger.2022.112021

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…A a previous study by Ueshima J et al, a SARC-F≥4 score was a predictor of death within 30 days of hospitalization (23). Takumi Noda et al found that sarcopenia assessment using the SARC-F was associated with increased in-hospital mortality in older patients, as well as heightened short-term mortality in individuals with CVD (24). A primary factor that leads to increased mortality in sarcopenia patients is the higher fall risks, which results from the reduction in muscle mass and strength that impairs the balance (25).…”

Section: Discussionmentioning

confidence: 92%

Association between SARC-F scores and risk of adverse outcomes in older patients with cardiovascular disease: a prospective study at a tertiary hospital in Ho Chi Minh City

Nguyen,

Dinh

et al. 2024

Preprint

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Background Older patients typically face elevated mortality rates and greater medical resource utilization during hospitalizations compared to their younger counterparts. Sarcopenia, serving as a prognostic indicator, is related to disability, diminished quality of life, and increased mortality. The SARC-F questionnaire, known for its cost-effectiveness, offers a valuable means of assessing sarcopenia. Method Participants aged 60 and above, admitted to the Cardiovascular Department from November 2021 to June 2022, were recruited in the prospective, single-center study. The prognostic outcomes included all-cause death and the initial occurrence of emergency rehospitalization within six months’ post-discharge. The Kaplan–Meier analysis compared the overall survival rates between different SARC-F score groups. Results The study enrolled 285 patients with a median age of 74 (67, 81). During a 6-month follow-up period, there were 14 cases of mortality. A SARC-F score of 4 or higher was significantly associated with an increased risk of all-cause mortality, with HR of 2.02 (95% CI: 1.39 – 2.92, p < 0.001), and higher incidence of re-hospitalization events with RR of 1.66 (95% CI: 1.06 to 2.59, p = 0.026). Kaplan-Meier survival analysis indicated a notably higher mortality rate in the patients with high SARC-F scores (p < 0.001). Conclusions In elderly patientswith cardiovascular disease, the SARC-F questionnaire could serve as a simple and cost-effective method for detecting mortality and the risk of rehospitalization.

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Section: Discussionmentioning

confidence: 92%

Association between SARC-F scores and risk of adverse outcomes in older patients with cardiovascular disease: a prospective study at a tertiary hospital in Ho Chi Minh City

Nguyen,

Dinh

et al. 2024

Preprint

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“…Furthermore, only 35.3% of the cohort had a CABG surgery whereas in our cohort, a cardiac procedure was one of the inclusion criteria [ 13 ]. In a cohort with a similar mean age compared to our cohort, Noda et al [ 14 ] used the SARC-F questionnaire to detect sarcopenia in older CVD patients with cognitive impairment. The results revealed similar SARC-F scores in the main cohort as well as in the sarcopenic and non-sarcopenic groups [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…In older patients with CVD, a SARC-F ≥ 4 is associated with higher risk of an adverse advent compared with those patients with SARC-F < 4 (adjusted hazard ratio: 1.78; 95% confidence interval: 1.03–3.07; p = 0.040) [ 13 ]. Furthermore, SARC-F scores ≥4 are associated with poorer results of motor function tests, quality of life as well as poorer prognosis and increased risk of rehospitalization due to CVD [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation – results from a prospective, observational cohort pre-study

Steinmetz,

Krause,

Sulejmanovic

et al. 2024

BMC Geriatr

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Background The prevalence of sarcopenia and its impact in older patients undergoing inpatient cardiac rehabilitation (iCR) after cardiac procedure has been insufficiently studied. The main aim of this study was to evaluate the prevalence of sarcopenia and quantify the functional capacity of older sarcopenic and non-sarcopenic patients participating in iCR. Methods Prospective, observational cohort study within the framework of the ongoing multicenter prehabilitation study “PRECOVERY”. A sample of 122 patients ≥75 years undergoing iCR after cardiac procedure were recruited in four German iCR facilities and followed up 3 months later by telephone. At iCR (baseline), the Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F) questionnaire was used to identify sarcopenic patients. In addition, Katz-Index, Clinical Frailty Scale (CFS), handgrip strength (HGS), Short Physical Performance Battery (SPPB) and 6-minute walk distance (6MWD) measured functional capacity and frailty at baseline. Outcomes were prevalence of sarcopenia and the correlation of sarcopenia to functional capacity and frailty at baseline as well as the SARC-F score at follow-up. The Wilcoxon test was applied for pre-post-test analysis. Correlation between sarcopenia and 6MWD, SPPB score and HGS was tested with the eta coefficient with one-way ANOVA. Results Complete assessments were collected from 101 patients (79.9 ± 4.0 years; 63% male). At baseline, the mean SARC-F score was 2.7 ± 2.1; 35% with sarcopenia. Other baseline results were Katz-Index 5.7 ± 0.9, CFS 3.2 ± 1.4, HGS 24.9 ± 9.9 kg, SPPB score 7.5 ± 3.3 and 6MWD 288.8 ± 136.5 m. Compared to baseline, fewer patients were sarcopenic (23% versus 35%) at follow-up. In the subgroup of sarcopenic patients at baseline (n = 35), pre-post comparison resulted in a significant SARC-F improvement (p = 0.017). There was a significant correlation between sarcopenia measured by SARC-F and poor results in the assessments of functional capacity (p < 0.001; r > 0.546). Conclusions The prevalence of sarcopenia in older patients at iCR after cardiac procedure is high (35%) and remains high at follow-up (23%). Sarcopenia screening is important since the diagnosis of sarcopenia in these patients correlates significantly with poor functional capacity. The results indicate that these patients may benefit from prehabilitation aimed at improving perioperative outcomes, increasing functional capacity and mitigating adverse effects. Trial registration German Clinical Trials Register (DRKS; http://www.drks.de; DRKS00032256). Retrospectively registered on 13 July 2023.

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“…Skeletal muscle mass and handgrip strength tests represent non-invasive, uncomplicated measures commonly utilized for diagnosing sarcopenia [ 22 ]. The findings of these measures serve as valuable indicators that can predict rehospitalization rates and prognosis in patients with CVD [ 23 , 24 ]. Skeletal muscle mass was measured using a body composition analyzer (MC-980A; Tanita Corp., Tokyo, Japan) based on direct segmented multifrequency bioelectrical impedance analysis [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in Cardio–Vascular–Skeletal Muscle Coupling

Ogawa,

Kanzaki,

Ikeda

et al. 2023

JCM

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The relationship between arterial stiffness and oxygen uptake (VO2) in patients with acute myocardial infarction (AMI) remains unclear. We aimed to investigate this relationship and factors contributing to VO2 in patients with AMI. The role of arterial stiffness in cardio–skeletal muscle coupling during exercise was then elucidated. Upon discharge, we measured exercise capacity using cardiopulmonary exercise testing (CPX), assessed arterial stiffness with the cardio–ankle vascular index (CAVI), and determined body composition to assess the skeletal muscle mass of 101 patients with AMI. Patients were categorized based on their CAVI scores into three groups: (i) normal (CAVI: ≤7.9), (ii) borderline (CAVI: 8.0–8.9), and (iii) abnormal (CAVI: ≥9.0). Subsequently, VO2 was compared among these groups. The relationship between the CAVI and VO2 Peak during CPX and factors contributing to VO2 Peak were investigated. The abnormal CAVI group had a significantly lower VO2 Peak than the normal and borderline groups. The CAVI was associated with VO2 Peak. Furthermore, the CAVI was found to be a factor contributing to VO2 Peak. These findings suggest that arterial stiffness in tissue blood distribution and blood supply causes systemic exercise limits in patients with AMI. This suggests that arterial stiffness plays a significant role in cardio–vascular–skeletal muscle coupling.

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SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment

Cited by 10 publications

References 35 publications

Association between SARC-F scores and risk of adverse outcomes in older patients with cardiovascular disease: a prospective study at a tertiary hospital in Ho Chi Minh City

Association between SARC-F scores and risk of adverse outcomes in older patients with cardiovascular disease: a prospective study at a tertiary hospital in Ho Chi Minh City

The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation – results from a prospective, observational cohort pre-study

Determination of Peak Oxygen Uptake in Patients with Acute Myocardial Infarction: The Role of Arterial Stiffness in Cardio–Vascular–Skeletal Muscle Coupling

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