Sarcoidose cutânea sobre cicatrizes: relato de caso

Mantese, Sônia Antunes de Oliveira; Berbert, Alceu; Cesário, Thaís Silveira; Silva, Henrique Borges da

doi:10.1590/s0365-05962010000600021

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…In our patient, posteroanterior chest radiography and mediastinal CT scanning ruled out the presence of cardiac, pulmonary, and/or lymph nodal depositions. However, elevated serum levels of calcium, angiotensin-converting enzyme, and alkaline phosphatase, as biochemical markers of active sarcoidosis (12)(13)(14), confirmed our diagnosis.…”

Section: Discussionsupporting

confidence: 72%

“…In the United States, the annual incidence of sarcoidosis has been noted as 35.5/100,000 in blacks and 10.9/100,000 in whites (5,9,11). So, this condition seems to be extremely rare in Brazilians; however, an increase in its incidence has been reported in recent decades (13) with a predilection for young (25 and 35 years) and middle-aged (44 -55 years) women (14). African-American and Northern European women are far more affected by this condition (11).…”

Section: Discussionmentioning

confidence: 99%

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Upper Lip Nodule as the First Manifestation of Sarcoidosis: A Case Report

Borges,

Ferreira,

Henrique

et al. 2023

J Skin Stem Cell

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Introduction: Sarcoidosis is a chronic disorder characterized by the presence of multiple granules, which could affect different systems and tissues. These granules are histologically characterized by non-caseous granulomatous inflammation; however, their etiology is still unknown. Previous reports state that different antigens may be involved. Sarcoidosis has been rarely reported in the Brazilian population. The objective of this study was to report a clinical case of sarcoidosis presenting with oral manifestations as the first sign and symptom. Case Presentation: An 85-year-old, nonsmoking, white woman was referred to the Department of Stomatology of our clinic in 2019, complaining of a persistently growing nodule on the upper lip and in the right arm subcutaneous tissue lasting for three months. Both lesions were painless and non-mobile/cohesive nodules with borrachoid consistency on palpation, well-delimited margins, and overlying normal-colored mucosa/skin. The oral nodule was surgically excised and sent for routine histopathological analysis, revealing granulomatous inflammation, the presence of central lobules of activated macrophages, epithelioid histiocytes, multinucleated Langerhans cells, and a peripheral cuff of mononuclear cells (lymphocytes). There was no evidence of central necrotic areas; however, asteroid bodies (i.e., starry inclusions) were rarely interspersed within multinucleated Langerhans cells. Warthin-Starry, Fite, and PAS special staining did not show any evidence of granulomatous pathogens, which was compatible with non-infectious granulomatosis. Complementary tests revealed hypercalcemia and elevated serum levels of alkaline phosphatase and angiotensin-converting enzyme. Conclusions: Sarcoidosis can manifest itself in several ways, so the diagnostic process needs to be thorough and comprehensive to confirm the disease. In addition, disease progression should be regularly monitored in patients.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Upper Lip Nodule as the First Manifestation of Sarcoidosis: A Case Report

Borges,

Ferreira,

Henrique

et al. 2023

J Skin Stem Cell

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“…We don't know the exact mechanism for this, but different pre-operation state of upper eyelids, surgeon's skill or different post-operation care could be the reason for the asymmetric appearance of scar sarcoidosis. Similar to our case, Mantese et al3 reported the patients who was diagnosed with scar sarcoidosis that developed only part of the scars. Although the patient had blepharoplasty, hysterectomy and caesarean, she had sarcoidosis on left upper eyelid and on the left lateral side of infra-umbical scar.…”

supporting

confidence: 88%

Scar Sarcoidosis Developed after Blepharoplasty in Acute Lymphoblastic Leukemia Patient

Kim

et al. 2017

Ann Dermatol

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“…Most patients with scar sarcoidosis have other systemic manifestations, particularly changes to the lungs. 2 4 9) …”

Section: Discussionmentioning

confidence: 99%

I Can Not Wear My Sunglasses: An Unusual Sarcoidosis Presentation

et al. 2017

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A 39-year-old Caucasian man was referred to University Hospital Salamanca from a primary care unit due to the presence of an erythematous violaceous nodule at the superior portion of his nose. Physical examination indicated that the firm, fixed erythematous violaceous nodule measured approximately 2 cm in diameter and was located inferior to a scar on the nasal bridge. Cutaneous involvement in sarcoidosis occurs in 25% of cases. A wide range of clinical presentations of cutaneous sarcoidosis is recognized. Skin lesions are classified as either non-specific, of which erythema nodosum is the most representative and specific, or as granulomatous, which includes maculopapular nodules, plaques, infiltrated scars, lupus pernio, ulcerations, warty lesions and erythroderma. Scar sarcoidosis is a type of cutaneous sarcoidosis.

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Sarcoidose cutânea sobre cicatrizes: relato de caso

Cited by 6 publications

References 7 publications

Upper Lip Nodule as the First Manifestation of Sarcoidosis: A Case Report

Upper Lip Nodule as the First Manifestation of Sarcoidosis: A Case Report

Scar Sarcoidosis Developed after Blepharoplasty in Acute Lymphoblastic Leukemia Patient

I Can Not Wear My Sunglasses: An Unusual Sarcoidosis Presentation

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