Sarcoidosis and haematological malignancies: is there an association?

Gooneratne, Lallindra; Nagi, Waseem; Lim, Zi Yi; Ho, A Y L; Devereux, Stephen; Pagliuca, Antonio; Mufti, Ghulam J.

doi:10.1111/j.1365-2141.2008.06986.x

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…The temporal relationship between sarcoidosis and neoplasia does not appear to be random, especially in malignant hematological disease; the sarcoidosis, almost invariably, pre-dates the neoplasia (average of about 78 months) [10].…”

Section: Discussionmentioning

confidence: 99%

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A case of pulmonary sarcoidosis preceding polycythemia vera with literature review

Tirotta

Durante

2010

Rheumatol Int

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Section: Discussionmentioning

confidence: 99%

“…The most common manifestations are hemolytic or non-hemolytic anemia, leucopenia/lymphopenia, monocytosis, eosinophilia and autoimmune or non-autoimmune thrombocytopenia. Iron deWciency and secondary erythrocytosis are even more unusual [10][11][12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

A case of pulmonary sarcoidosis preceding polycythemia vera with literature review

Tirotta

Durante

2010

Rheumatol Int

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“…The relative risk of developing lymphoid malignancies was found to be 13.2% in patients with sarcoidosis [24, 25]. …”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence?

Hassanein

Karapetyan

Khan

et al. 2018

Case Reports in Hematology

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Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas in different organs. Sarcoidosis associated with monoclonal gammopathy of undetermined significance (MGUS) is a rare finding with only 10 cases reported to date. We describe a 79-year-old male patient who presented with dry mouth for 4 months. Lip biopsy done prior to admission showed nonnecrotizing epithelioid cell granulomas. On admission, laboratory analysis was significant for elevated calcium, decreased parathyroid hormone, increased erythrocyte sedimentation rate, undetectable parathyroid hormone-related peptide (PTHrp), mildly decreased 25-hydroxyvitamin D, elevated 1,25-dihydroxyvitamin D, elevated angiotensin converting enzyme, and positive Bence Jones protein in the urine. Serum protein electrophoresis showed an elevated gamma globulin level at 38% and an IgG monoclonal gammopathy with an M-spike of 1.47. Bone marrow biopsy was consistent with MGUS. The patient showed significant improvement with steroids and was discharged with close follow-up from nephrology and oncology. Salivary gland involvement in patients with sarcoidosis is a rare finding. Our case is a valuable addition to the small number of cases described in the literature supporting an association between plasma cell disorders and sarcoidosis. Larger prospective studies are needed to determine if a true association between the two diseases exists.

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“…Se cree que la presencia de ADN de Mycobacterias en las lesiones sarcoi-dales o una lesión en la pared celular, son la causa de que un individuo presente mayor susceptibilidad a padecerla, aunque Brown y Col rechazan esta asociación 4,7 . Algunos autores incluso creen que la sarcoidosis incrementa el riesgo de padecer alguna neoplasia hematoló-gica, aunque esto es aún controvertido 8 . La sarcoidosis se caracteriza por presentar una elevada respuesta inmune tipo Th1, la cual produce una formación descontrolada de granulomas y un incremento de los linfocitos TCD4+ en los pulmones afectados, incrementando dramáticamente su número; mientras que las células TCD8+ son desreguladas.…”

Section: Discussionunclassified

Sarcoidosis infantil. Una rara enfermedad pediátrica: Caso clínico

et al. 2011

Rev. chil. pediatr.

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Sarcoidosis and haematological malignancies: is there an association?

Cited by 13 publications

References 7 publications

A case of pulmonary sarcoidosis preceding polycythemia vera with literature review

A case of pulmonary sarcoidosis preceding polycythemia vera with literature review

Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence?

Sarcoidosis infantil. Una rara enfermedad pediátrica: Caso clínico

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