Sarcoidosis as a systemic disease

Sehgal, Virendra; Riyaz, Najeeba; Chatterjee, Kingshuk; Venkatash, P.; Sharma, Sonal

doi:10.1016/j.clindermatol.2013.11.002

Cited by 17 publications

(17 citation statements)

References 89 publications

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Section: Cutaneous Sarcoidosismentioning

confidence: 99%

“…There is a spectrum of cutaneous manifestations in sarcoidosis that may develop in 20%-35% of patients (2,3,13,96). The lesions specific for sarcoidosis include maculopapule, nodule, plaque, subcutaneous nodule, infiltrative scar, and lupus pernio (2,3,13,96). Erythema nodosum; calcifications; prurigo; erythema multiforme; and nail changes such as clubbing, onycholysis, and subungual hyperkeratosis are the nonspecific findings seen in sarcoidosis (2,3,13,96).…”

Section: Cutaneous Sarcoidosismentioning

confidence: 99%

“…The lesions specific for sarcoidosis include maculopapule, nodule, plaque, subcutaneous nodule, infiltrative scar, and lupus pernio (2,3,13,96). Erythema nodosum; calcifications; prurigo; erythema multiforme; and nail changes such as clubbing, onycholysis, and subungual hyperkeratosis are the nonspecific findings seen in sarcoidosis (2,3,13,96). Papules are the most common manifestations and are typically tiny flesh-colored, red, or yellow lesions seen around the eyes and nasolabial folds and in the head and neck regions (96).…”

Section: Cutaneous Sarcoidosismentioning

confidence: 99%

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Sarcoidosis from Head to Toe: What the Radiologist Needs to Know

Ganeshan¹,

Menias²,

Lubner³

et al. 2018

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Sarcoidosis is a multisystem granulomatous disorder characterized by development of noncaseating granulomas in various organs. Although the etiology of this condition is unclear, environmental and genetic factors may be substantial in its pathogenesis. Clinical features are often nonspecific, and imaging is essential to diagnosis. Abnormalities may be seen on chest radiographs in more than 90% of patients with thoracic sarcoidosis. Symmetric hilar and mediastinal adenopathy and pulmonary micronodules in a perilymphatic distribution are characteristic features of sarcoidosis. Irreversible pulmonary fibrosis may be seen in 25% of patients with the disease. Although sarcoidosis commonly involves the lungs, it can affect virtually any organ in the body. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT are useful in the diagnosis of extrapulmonary sarcoidosis, but imaging features may overlap with those of other conditions. Familiarity with the spectrum of multimodality imaging findings of sarcoidosis can help to suggest the diagnosis and guide appropriate management. RSNA, 2018.

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Section: Cutaneous Sarcoidosismentioning

confidence: 99%

Section: Cutaneous Sarcoidosismentioning

confidence: 99%

Section: Cutaneous Sarcoidosismentioning

confidence: 99%

See 1 more Smart Citation

Sarcoidosis from Head to Toe: What the Radiologist Needs to Know

Ganeshan¹,

Menias²,

Lubner³

et al. 2018

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103

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“…It should be emphasised that sarcoidosis is a diagnosis of exclusion. Clinical features, biopsy findings and the exclusion of other granulomatous processes are all essential in making the diagnosis 28 29…”

Section: Non-necrobiotic Granulomatous Conditionsmentioning

confidence: 99%

Non-infectious granulomatous conditions of the skin: a clinicopathological approach to diagnosis

2015

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Granulomatous disorders of the skin are diverse and include infectious and non-infectious conditions. They are a source of confusion to many dermatologists and pathologists, including even the most experienced dermatopathologists. Correlation with clinical picture, serology, microbiology and careful morphological examination is essential for accurate diagnosis. Most cases require ancillary histopathological studies to reach a final diagnosis. This review discusses important non-infectious granulomatous conditions of the skin and presents a practical approach when confronted with such entities.

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“…Non-necrotizing granuloma is formed as a result of the collection of highly differentiated mononuclear phagocytes (epithelioid cells and multinucleated giant cells), Schaumann bodies or asteroid bodies, patchy fibrosis, and lymphocytes (3,15,16). Three categories of potential etiologic factors have previously been defined: infective, noninfective, and genetic (17). Viruses (herpes, Epstein-Barr, retrovirus, coxsackie B virus, and cytomegalovirus), Borrelia burgdorferi, Propionibacterium acnes, Mycobacterium tuberculosis and other mycobacteria, Mycoplasma orale, beryllium, aluminum, zirconium, clay, talc, hairspray, pine tree pollen, peanut dust, mineral oil, and drugs (e.g.…”

Section: Epidemiologymentioning

confidence: 99%