Sarcoidosis as an unusual cause of hepatic dysfunction following reduced intensity conditioned allogeneic stem cell transplantation

Sarcoidosis in donor-derived tissues after haematopoietic stem cell transplantation

“…In the present case and previously reported cases [3][4][5][6][7], the possibility of GVHD or a sarcoid reaction should be considered. Although chronic GVHD usually develops more than 3 months after transplantation, a series of findings suggestive of sarcoidosis in the present case appeared at 16 months after transplantation.…”

“…Three patients underwent autograft transplantation (cases 4-6) [5], and another three patients and the present case received stem cells from unrelated donors [6,7]. None of the donors in cases 3-9 or the present case had been diagnosed to have sarcoidosis before undergoing transplantation [5][6][7]. The possibility of a transmissible agent was suggested for the development of sarcoidosis in the recipients in cases 1 and 2 [3,4].…”

Sarcoidosis-associated MHC Ags and the development of cutaneous and nodal granulomas following allogeneic hematopoietic cell transplant

“…3,5,7 Unfortunately, not all reports have mentioned the HLA typing. 4,6 We suspect that the immune dysregulation post alloHCT promotes development of de novo sarcoidosis in a subgroup of HLA-susceptible patients. Understanding the association of these specific HLA types with sarcoidosis may further the understanding of the mechanisms of sarcoidosis.…”

“…[3][4][5] However, there are some cases where the donor had no evidence of sarcoidosis. 6 Patient characteristics of all reported cases of sarcoidosis post alloHCT are summarized in Table 1.…”

Donor cell-derived sarcoidosis after allogeneic BMT

“…[1][2][3][4][5] Previous study never referred to chimerism of sarcoidosis lesions. This is the first report in which chimerism of lymph nodes where sarcoidosis had infiltrated was investigated and the first study showing that lymph nodes contained mostly donor-type cells.…”