Sarcoidosis Associated With Pegylated Interferon Alfa and Ribavirin Treatment for Chronic Hepatitis C

Cytokines Induced Skin Adverse Reactions

“…• Polyethylene glycol (PEG)-containing product, seems to induce more frequent adverse reactions and a large number of side-effect cases related to combination therapy with ribavirin have been reported [65][66][67][68][69].…”

The Role of Type I IFN and TNF-α in the Pathogenesis of Sarcoidosis

“…Its onset may vary from 2 weeks to 3 years after beginning of treatment. Men and women are equally affected [42,43], and the mean age of patients was approximately 50 years [39]. The majority (roughly two-thirds) of cases of IIS arise during the first 6 months of IFN therapy, but clinical manifestations may also appear after discontinuation of the antiviral treatment [38].…”

Hepatitis C virus and autoimmunity

“…Even treatment-naive HCV-infected patients develop sarcoidosis with mainly pulmonary involvement and also with cutaneous involvement. Sarcoidosis may initially manifest or be reactivated during or shortly after treatment with antiviral therapy in patients with chronic HCV infection [134,135].…”