Sarcoidosis

Thomas, Karl W.

doi:10.1001/jama.289.24.3300

Cited by 223 publications

(172 citation statements)

References 20 publications

Supporting

Mentioning

145

Contrasting

Unclassified

Order By: Relevance

“…1 The disease is char acterised by the presence of non-case ating granulomas and whilst any organ may be affected the most common sites are the lungs and lymph nodes. 2 More than 3,000 new cases of sarcoidosis are diagnosed in the UK each year with a higher incidence among young adults aged 20-40. 2,3 It occurs in all races but appears to be more common in people of African-American, Afro-Caribbean or Scandinavian origin.…”

Section: Introductionmentioning

confidence: 99%

“…2 More than 3,000 new cases of sarcoidosis are diagnosed in the UK each year with a higher incidence among young adults aged 20-40. 2,3 It occurs in all races but appears to be more common in people of African-American, Afro-Caribbean or Scandinavian origin. 2,4,5 It has been suggested that sarcoido sis is due to an immunological response to an infective trigger in a genetically predisposed individual, with the most likely candidates being mycobacteria and propionibacteria.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 It occurs in all races but appears to be more common in people of African-American, Afro-Caribbean or Scandinavian origin. 2,4,5 It has been suggested that sarcoido sis is due to an immunological response to an infective trigger in a genetically predisposed individual, with the most likely candidates being mycobacteria and propionibacteria. 5 Affected patients may be asymp tomatic or have a wide range of non specific symptoms depending on the organs affected and stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Orofacial presentations of sarcoidosis – a case series and review of the literature

et al. 2008

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Orofacial presentations of sarcoidosis – a case series and review of the literature

et al. 2008

View full text Add to dashboard Cite

“…Sarcoidosis is a multisystem, non‐caseating granulomatous disorder of unknown aetiology, whose epidemiology underlies geographic and ethnic variations 1, 2. Cardiac sarcoidosis (CS) may occur isolatedly without any concurrent extracardiac presentation or in the context of multiorgan sarcoid affection.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular magnetic resonance imaging and clinical performance of somatostatin receptor positron emission tomography in cardiac sarcoidosis

et al. 2017

View full text Add to dashboard Cite

AimsCardiac affection constitutes a major limiting condition in systemic sarcoidosis. The primary objective of this study was to investigate the persistence rate of cardiac sarcoid involvement by cardiovascular magnetic resonance (CMR) imaging in patients diagnosed with cardiac sarcoidosis (CS). Moreover, we examined the additional insights into myocardial damage's characteristics gained by somatostatin receptor scintigraphy.Methods and resultsIn a pilot study, we had previously identified cardiac involvement—diagnosed by CMR imaging—to be present in 29 of 188 patients (15.4%) with histologically proven, extra‐CS. Out of these initial 29 CS‐positive patients, 27 patients (49.9 ± 11.8 years, 59.3% male) were presently re‐examined and underwent a second CMR study and complementary standard clinical testing. Somatostatin receptor scintigraphy using the ligand 68Ga‐DOTATOC was additionally performed when clinically indicated (17 patients). Within a median follow‐up period of 2.6 years, none of the initial 29 patients deceased or experienced aborted sudden cardiac death. However, two patients developed third‐degree atrioventricular block that required device therapy. Among the 27 re‐examined CS patients, pathological CMR findings persisted in 14 of 27 patients (51.9%). CS remission was primarily due to a resolution of acute inflammatory processes. 68Ga‐DOTATOC positron emission tomography/computed tomography (PET/CT) identified one patient with regions of raised tracer uptake that concorded with acute inflammatory changes, as assessed by CMR; this patient received no immunosuppressive medication at the time of PET/CT execution.ConclusionsWithin follow‐up, CS persisted in barely half the patients, and the patients were not afflicted with cardiac death. Additional 68Ga‐DOTATOC PET/CT allowed for visualization of acute myocardial inflammation.

show abstract

“…The cause of the disease process is unknown, and the hallmark of sarcoidosis is the presence of noncaseating granulomas found throughout the body [15,31]. Although radiographic findings and laboratory values may lead to the diagnosis, biopsy of the involved organ systems is the gold standard [7].…”

Section: Introductionmentioning

confidence: 99%

Isolated intramedullary neurosarcoidosis of the thoracic spine: case report and review of the literature

2011

View full text Add to dashboard Cite

Sarcoidosis can involve the central nervous system in approximately 5-15% of cases. Any part of the nervous system can be involved, so presentation can be quite varied. Isolated disease of the spinal cord is even less common and reports are limited to single cases and small series. Although in the setting of systemic disease the diagnosis can be made with skin or lymph node biopsy, isolated disease of the spinal cord presents a diagnostic challenge. We present a case of isolated intramedullary neurosarcoidosis of the distal thoracic spinal cord presenting with posterior column dysfunction. Imaging demonstrated T2 changes in the patient's lower thoracic cord adjacent to disc herniation. Over time, however, his symptoms progressed despite decompression, and the abnormal region began to exhibit focal contrast enhancement. The persistence of symptoms as well as the new enhancement led us to perform a spinal cord biopsy, which demonstrated histopathological findings consistent with sarcoidosis. Further workup failed to reveal any evidence of systemic disease. Intramedullary sarcoidosis without systemic sarcoidosis is extremely rare. With its variable imaging appearance and inconsistent clinical manifestations, it can be difficult to diagnose. It should be considered in the differential diagnosis of a mass-like intramedullary lesion with progressive symptoms. Biopsy with histopathological correlation may be the only definite management option.

show abstract

Sarcoidosis

Cited by 223 publications

References 20 publications

Orofacial presentations of sarcoidosis – a case series and review of the literature

Orofacial presentations of sarcoidosis – a case series and review of the literature

Cardiovascular magnetic resonance imaging and clinical performance of somatostatin receptor positron emission tomography in cardiac sarcoidosis

Isolated intramedullary neurosarcoidosis of the thoracic spine: case report and review of the literature

Contact Info

Product

Resources

About