Sarcoidosis in monozygotic twins

Vj, Swale; Spector, TD; Va, Bataille

doi:10.1046/j.1365-2133.1998.02387.x

Cited by 11 publications

(5 citation statements)

References 5 publications

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“…A study of 95 sets of twins with acne showed that 98% of identical twin pairs were affected compared to 46% of dizygotic twins [7]. Two other studies confirmed this high concordance in monozygotic compared to dizygotic twins [3, 8]. In one of them, the influence of genetic factors and family history on the occurrence of acne was estimated to be 81% [3].…”

Section: Discussionmentioning

confidence: 55%

Heredity: A Prognostic Factor for Acne

Ballanger¹,

Baudry²,

Nguyen³

et al. 2006

Dermatology

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Background: The role of heredity in acne severity and therapeutic response remains unclear. Objective: A prospective epidemiologic study was performed to compare clinical and evolutive features of acne and response to treatment in 151 patients with acne with (A+) or without (A–) family history of acne. Methods: A+ and A– patients were compared on clinical and therapeutic criteria. A+ patients were then distributed into subgroups (M+, F+, M+F+) following the origin of family history (father: F, mother: M). Results: The clinical profile was similar in the A+ and A– populations. Acne occurred earlier and more often before puberty in the A+ population, in which oral treatments and relapse after isotretinoin were more frequent. Retentional lesions (number and extent) were more important in the M+ and M+F+ populations. Conclusion: This study confirms the importance of heredity as a prognostic factor for acne. Family history of acne is associated with earlier occurrence of acne, increased number of retentional lesions and therapeutic difficulties.

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Section: Discussionmentioning

confidence: 55%

Heredity: A Prognostic Factor for Acne

Ballanger¹,

Baudry²,

Nguyen³

et al. 2006

Dermatology

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“…Many skin diseases including very rare ones have been reported to be more correlated within MZ twins compared with DZ twins, and these include sarcoidosis, lupus, lichen sclerosus and atrophicus, albinism, vitiligo, Netherton syndrome amongst many. [39][40][41][42] Polymorphic light eruption has also been shown to be under significant genetic influence with heritability of 84%. 43 The UK Twin registry in collaboration with other groups identified new genes for male pattern baldness and female hair thinning.…”

Section: Other Skin Diseasesmentioning

confidence: 99%

The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data

Bataille

Lens

Spector

2012

Acad Dermatol Venereol

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Twins have always fascinated medical research even before the discovery of DNA and the understanding of the differences between identical and non-identical twins. Dermatology with the benefit of being able to visualize phenotypes was one of the first specialities reporting on the fascinating concordance in identical (MZ) twins in the 1920's. Over the last 20 years, the heritability of skin diseases using twins has been clearly demonstrated, across a wide variety of traits including melanoma, polymorphic light eruption, psoriasis, eczema and acne. Other rarer diseases have also been shown to have a significant genetic basis such as lupus, sarcoidosis and lichen sclerosus. Following evidence of heritability for many skin disease the next step was Genome-Wide Association Studies (GWAS) which are uncovering new genes in large twin cohorts. The twin model is also ideal for the new field of epigenetics, investigating subtle differences in DNA methylation within discordant MZ pairs for a disease, as well as differences in CNVs. Twins are also valuable for examining differences in gene function via RNA expression in twins discordant for a skin trait or disease.

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“…34 An erythema nodosum-like eruption with the histological changes of sarcoidosis has also been described. 40 Children presenting before the age of 4 years, usually have the triad of rash, uveitis, and arthritis, 41,42 without apparent pulmonary involvement. [36][37][38][39] There are reports of its occurrence in monozygotic twins.…”

Section: Sarcoidosismentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Sarcoidosis in monozygotic twins

Cited by 11 publications

References 5 publications

Heredity: A Prognostic Factor for Acne

Heredity: A Prognostic Factor for Acne

The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data

The granulomatous reaction pattern

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