2010
DOI: 10.1097/mcp.0b013e32833ae508
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Sarcoidosis in the aged: review and management

Abstract: Autopsy studies revealed that both apparent and subclinical or inapparent systemic involvement of sarcoidosis might exist in aged patients with sarcoidosis. Aged sarcoidosis patients often present with unusual clinical features of sarcoidosis. Occasionally, these features resemble malignancy. New treatment with tumor necrosis factor antagonists for intractable sarcoidosis, methylphenidate hydrochloride for fatigue, and bosentan for sarcoidosis-associated pulmonary hypertension may be effective in sarcoidosis i… Show more

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Cited by 15 publications
(5 citation statements)
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“…Death mostly resulted from progressive respiratory failure, neurosarcoidosis and cardiac involvement. Although the most commonly cause of death was reported to be respiratory failure, some autopsy results suggested the cardiac sarcoidosis as the main reason [28,32]. In our study, two (2%) patients died during the follow-up and, despite the presence of concomitant systemic diseases, their reason of death was reported to be progressive respiratory failure.…”
Section: Discussionmentioning
confidence: 39%
“…Death mostly resulted from progressive respiratory failure, neurosarcoidosis and cardiac involvement. Although the most commonly cause of death was reported to be respiratory failure, some autopsy results suggested the cardiac sarcoidosis as the main reason [28,32]. In our study, two (2%) patients died during the follow-up and, despite the presence of concomitant systemic diseases, their reason of death was reported to be progressive respiratory failure.…”
Section: Discussionmentioning
confidence: 39%
“…Among African–American individuals of both genders, sarcoidosis is observed mainly in the fourth decade of life . In Japanese population, it occurs in third decade of life, although some reports show second peak in women over 50 years of age as also observed in women in Scandinavian population .…”
Section: Epidemiologymentioning
confidence: 99%
“…The clinical picture is very variable and depends on ethnicity, duration of illness, site and extent of organ involvement, and activity of the granulomatous process. The disease can be clinically classified as asymptomatic sarcoidosis, sarcoidosis with non‐specific constitutional symptoms, and sarcoidosis with symptoms related to specific organ involvement .…”
Section: Clinical Manifestationsmentioning
confidence: 99%
“…Papers focusing on the age of onset and, particularly, on elderly sarcoidosis are very scarce. Most of them are case reports [4][5][6][7][8][9][10][11], and there are just a few reviews or observational cohort studies with a small number of patients and short followup which have been reported so far [12][13][14][15][16][17][18][19][20][21][22][23].…”
Section: Introductionmentioning
confidence: 99%