2013
DOI: 10.1186/1477-7819-11-235
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Sarcoidosis lymphoma syndrome - the value of PET-CT in the diagnosis

Abstract: We report a 52-year-old patient who developed B-cell non-Hodgkin’s lymphoma subsequent to sarcoidosis. Sarcoidosis was diagnosed 16 years ago and remained asymptomatic for 14 years after steroid treatment. She presented with new symptoms of arthralgia, photosensitivity, butterfly erythema, autoimmune antibodies (ANA, chromatin positivity) associated with progression of the known left upper lobe lesion on the chest X-ray suggesting primary autoimmune disease (systemic lupus erythematosus). As steroid treatment … Show more

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Cited by 17 publications
(10 citation statements)
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“…Çalışmamızda yüksek FDG tutulumlarına rağmen, CD4/CD8 oranı da sarkoidozda beklenin aksine düşük ortalama 3.4 (0.7-7.8) ve BAL sıvısında lenfosit hakimiyeti bulunmuştur. Sarkoidoz ve lenfomanın her ikisi de PET/BT'de lenf nodunda artmış glukoz tutulumu gösterir ve PET/BT, sarkoidoz tanısı için histopatolojik doğrulama gerekliliğini ortadan kaldırmaz 16 . Lenf nodu biyopsisi, mediastinoskopi, VATS, akciğer biyopsisi doku tanısı için başvurulan diğer invaziv yöntemlerdir 1 .…”
Section: Discussionunclassified
“…Çalışmamızda yüksek FDG tutulumlarına rağmen, CD4/CD8 oranı da sarkoidozda beklenin aksine düşük ortalama 3.4 (0.7-7.8) ve BAL sıvısında lenfosit hakimiyeti bulunmuştur. Sarkoidoz ve lenfomanın her ikisi de PET/BT'de lenf nodunda artmış glukoz tutulumu gösterir ve PET/BT, sarkoidoz tanısı için histopatolojik doğrulama gerekliliğini ortadan kaldırmaz 16 . Lenf nodu biyopsisi, mediastinoskopi, VATS, akciğer biyopsisi doku tanısı için başvurulan diğer invaziv yöntemlerdir 1 .…”
Section: Discussionunclassified
“…Aside from malignancy, infected and inflammatory tissues also accumulate FDG; this makes FDG PET less specific. Specificity of FDG PET may be increased when it is fused with CT images [ 5 , 6 ].…”
Section: Case Presentationmentioning
confidence: 99%
“…Although FDG PET/CT can evaluate disease activity of mediastinal lymphadenopathies and lung lesions due to sarcoidosis, differentiating these lesions from malignant lymphoma remains difficult. Therefore, combining FAMT and FDG during post-therapy PET/CT studies may enable differentiation between sarcoidosis and suspicious residual lymphoma lesions [ 2 , 5 ].…”
Section: Case Presentationmentioning
confidence: 99%
See 1 more Smart Citation
“…In the majority of these reports; sarcoidosis was followed by lymphoma, and exceptionally both coexisting together [11]. By the second week of admission, follow up laboratory data showed persistence of high cholestatic parameters and further rise in serum ferritin (Table 1) Figures 1,2).…”
Section: Introductionmentioning
confidence: 99%