Sarcoidosis Presenting as a Lytic Lesion of the Mandible

Cain, Rachel B.; Tamura, Thomas K.; Elhosseiny, Abdelmonem; Vanisky, Edward J.; Brundage, William

doi:10.1016/j.joms.2012.01.014

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…A review of the literature was carried out to compare known cases of skull sarcoidosis and sarcoidosis of the maxillofacial bones between 1998 and 2020. The results are summarised in tables 1 and 2 28–42…”

Section: Clinical Presentationmentioning

confidence: 99%

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Extensive bony sarcoidosis of the head and neck region: a rare presentation

et al. 2021

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We present a rare case of sarcoidosis with extensive bony destruction of the maxillofacial and skull base bones. A 65-year-old woman was referred with an asymptomatic, non-healing dental socket. Examination revealed an oroantral fistula that was biopsied and repaired under general anaesthesia. Investigations included plain and cross-sectional imaging. Serological tests, in particular ACE, were normal. Histology showed benign florid granulomatous inflammation. At 6 months, the patient remained asymptomatic. She was re-referred 3 years later with further bony destruction of her maxilla and mandible. Repeat imaging showed intrathoracic lymphadenopathy and skull base involvement. Repeat biopsy confirmed granulomatous inflammation. Given the pulmonary, histological and radiological findings, a sarcoidosis diagnosis was made. Following multidisciplinary team meetings, the patient was treated with methotrexate and arrangements made for close monitoring. This case highlights the need for a consensus in identifying, treating and developing a follow-up protocol in such patients.

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Section: Clinical Presentationmentioning

confidence: 99%

“…Conversely, Cain et al present a case where a bony lesion in the mandible developed relatively early in the development of sarcoidosis 38. Furthermore, Cole et al present a case where an osseous lesion in the mandible was the only presentation of sarcoidosis with no systemic involvement 29…”

Section: Clinical Presentationmentioning

confidence: 99%

Extensive bony sarcoidosis of the head and neck region: a rare presentation

et al. 2021

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A Rare Presentation of Intraosseous Sarcoidosis of the Mandible Presenting as Peri-Implantitis: A Case Report and Literature Review

Cheema

Buckey

Holmgren

2022

Journal of Oral and Maxillofacial Surgery

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Orofacial sarcoidosis: report of three cases

Koutrakis

Sahu

Vasilyeva

et al. 2022

J Oral Med Oral Surg

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Introduction: Sarcoidosis is a systemic non-caseating granulomatous disorder of unknown etiology that may affect multiple organ systems. Head and neck involvement can present in unusual and often nonspecific ways. Observations: We report three cases of sarcoidosis with orofacial manifestations: one African American patient with an existing diagnosis who presented with perioral cutaneous involvement by sarcoidosis, and two Caucasian patients with cases where the initial oral presentation – diffusely affected gingiva in one and intraosseous jaw involvement with resultant dental implant failure in the other – led to workup and establishment of the diagnosis of sarcoidosis. The patients were referred to rheumatology and dermatology for appropriate treatment. Conclusion: Although oral lesions of sarcoidosis are not common, they may be the first clinical manifestation of sarcoidosis. The practitioner should be aware of the possible manifestations and be able to formulate an informed clinical differential diagnosis.

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Sarcoidosis Presenting as a Lytic Lesion of the Mandible

Cited by 5 publications

References 10 publications

Extensive bony sarcoidosis of the head and neck region: a rare presentation

Extensive bony sarcoidosis of the head and neck region: a rare presentation

A Rare Presentation of Intraosseous Sarcoidosis of the Mandible Presenting as Peri-Implantitis: A Case Report and Literature Review

Orofacial sarcoidosis: report of three cases

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