Sarcoidosis presenting with an acute Guillain-Barré syndrome

Miller, R F; Sheron, Nicholas; Semple, S. J. G.

doi:10.1136/pgmj.65.768.765

Cited by 38 publications

(11 citation statements)

References 12 publications

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“…However in 3 of our cases, the neuropathy was primarily demyelinating, as has been reported by others [11,13,20,[23][24][25]. Occasionally in our cases, and also in previously reported cases, there was electrophysiologic evidence of demyelination, including partial conduction blocks on electrodiagnostic testing [23].…”

Section: Discussionsupporting

confidence: 70%

The natural history and long-term outcome of 57 limb sarcoidosis neuropathy cases

Burns

Dyck

Aksamit

2006

Journal of the Neurological Sciences

100

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Section: Discussionsupporting

confidence: 70%

The natural history and long-term outcome of 57 limb sarcoidosis neuropathy cases

Burns

Dyck

Aksamit

2006

Journal of the Neurological Sciences

100

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“…26 There are various forms including axonal or demyelinating sensory and/or motor neuropathies, which may affect single or multiple nerves, 26 and rarely Guillain-Barré syndrome. 22,39 Asymptomatic skeletal muscle involvement is more common than symptomatic muscle disease, with the latter having nodular, acute, or more commonly chronic myopathic forms that tend to affect females in their sixth decade. 26,40 Nodular myopathy is important because it may be confused with a soft tissue tumour.…”

Section: Movement Disordersmentioning

confidence: 99%

Sarcoidosis of the nervous system

Joseph

Scolding²

2007

Pract Neurol

112

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Although sarcoidosis is rarely confined to the nervous system, any neurological features that do occur frequently happen early in the course of the disease. The most common neurological presentation is with cranial neuropathies, but seizures, chronic meningitis and the effects of mass lesions are also frequent. The diagnostic process should first confirm nervous system involvement and then provide supportive evidence for the underlying disease; in the absence of any positive tissue biopsy, the most useful diagnostic tests are gadolinium enhanced MRI of the brain and CSF analysis, although both are non-specific. The mainstay of treatment is corticosteroids, but these often have to be combined with other immunosuppressants such as methotrexate, hydroxychloroquine or cyclophosphamide. There is increasing evidence that infliximab is a safe treatment with good steroid sparing capacity.

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“…Patterns of peripheral nerve involvement due to sarcoidosis are varied and include distal symmetric polyneuropathy, focal or multifocal neuropathy, and mononeuritis multiplex . Sarcoidosis has also been reported to present with an acute GBS‐like inflammatory polyneuropathy and, as in this case, associated with electrodiagnostic evidence of demyelinating neuropathy and conduction block . In a retrospective cohort of 57 patients with biopsy‐proven sarcoid neuropathy, positive neuropathic sensory symptoms, including pain, were more prominent than weakness and sensory loss .…”

Section: Discussionmentioning

confidence: 71%