Sarcoidosis Producing Portal Hypertension

Mino, Robert A.; Murphy, Arthur I.; Livingstone, Rodney

doi:10.1097/00000658-194911000-00012

Cited by 39 publications

(2 citation statements)

References 3 publications

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“…Abnormalities of liver function tests are seen in about 20-30% of the cases, whereas portal hypertension and cirrhosis are seen in less than 1% of patients ( 9 ). Portal hypertension associated with sarcoidosis was first reported in 1949 ( 10 , 11 ). Although portal hypertension usually occurs in association with liver cirrhosis, in sarcoidosis patients, it might be present without evidence of cirrhotic changes in the liver ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Hepatic and Gastric Involvement in a Case of Systemic Sarcoidosis Presenting with Rupture of Esophageal Varices

et al. 2017

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A 46-year-old woman presented with massive hematemesis, caused by the rupture of esophageal varices. The laboratory investigations showed pancytopenia, and imaging tests revealed hepatosplenomegaly and ascites. A diagnosis of systemic sarcoidosis was made based on biopsies of the liver, stomach, lungs, heart, and skin. Although fat deposition was predominant, non-caseating granuloma and cirrhotic changes were found in the liver. Non-caseating granuloma was also identified in a biopsy specimen from minute depressions of the gastric folds. This case illustrates the rare involvement of the digestive system in a case of systemic sarcoidosis.

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Section: Discussionmentioning

confidence: 99%

Hepatic and Gastric Involvement in a Case of Systemic Sarcoidosis Presenting with Rupture of Esophageal Varices

et al. 2017

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“…A small portion of hepatic sarcoidosis can be severe and rapidly progressive, with the occurrence of complications such as cirrhosis, portal hypertension, chronic cholestasis and Budd-Chiari syndrome [ 2 , 6 ]. The first report of portal hypertension associated with sarcoidosis was published in 1949 by Mino et al [ 8 ], followed by Katskin in 1950 [ 9 ]. Since then, the incidence of sarcoidosis with portal hypertension and cirrhosis has gradually been increasingly reported [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature

Tan¹,

Rashid

Rajan³

et al. 2012

Case Rep Gastroenterol

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Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sarcoidosis is difficult, considering that no single laboratory test or radiographic finding can definitively diagnose this systemic disease. Diagnosis of hepatic sarcoidosis relies heavily on histopathologic evaluation of two or more organs, a diagnostic modality that is invasive and may not be applicable to all patients. The treatment of hepatic sarcoidosis is challenging, with no large randomized controlled trials done to date. Physicians must be aware of the complications of hepatic sarcoidosis, and must include the same in the differential diagnosis of liver cirrhosis. We present a case of hepatic sarcoidosis complicated by portal hypertension and liver cirrhosis.

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Hepatic Sarcoidosis

Porter¹

1961

Arch Intern Med

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Sarcoidosis Producing Portal Hypertension

Cited by 39 publications

References 3 publications

Hepatic and Gastric Involvement in a Case of Systemic Sarcoidosis Presenting with Rupture of Esophageal Varices

Hepatic and Gastric Involvement in a Case of Systemic Sarcoidosis Presenting with Rupture of Esophageal Varices

Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature

Hepatic Sarcoidosis

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