Sarcoidosis with Pulmonary Fibrosis

Abehsera, M.; Valeyre, Dominique; Greniér, Philippe; Jaillet, Hélène; Battesti, J P; Brauner, M.

doi:10.2214/ajr.174.6.1741751

Cited by 250 publications

(63 citation statements)

References 26 publications

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“…Notably, almost half of our patients had developed pulmonary fibrosis based on CT, where traction bronchiectasis was the most frequent CT pattern found, consistent with data of a previous study 30. Identification of prognostic variables based on HRCT patterns has also produced discordant results,27303233 probably related to differences in the methodology used in various studies or (perhaps more likely) related to disease expression moderated by gene-environmental interaction. Further large-scale studies are warranted to explore such effects within the Arab population.…”

Section: Discussionsupporting

confidence: 88%

“…Several studies have investigated the role of CT, including high resolution CT (HRCT), in sarcoidosis patients 25–30. However, routine CT scanning is not advocated in management of sarcoidosis except in patients in whom normal or atypical chest radiography is evident, or specific complications are suspected, such as in patients with pulmonary fibrosis, bronchiectasis, aspergilloma, or malignancy 131.…”

Section: Discussionmentioning

confidence: 99%

“…In our current study we did not attempt to determine such relationships, as CT scans were not obtained systematically, and were not performed simultaneously with PFT evaluation. Abehsera and associates30 evaluated chest CT scans of sarcoid patients who displayed chest radiographic evidence of fibrotic changes (Stage IV disease), and found the following three different CT patterns: bronchial distortion including traction bronchiectasis (predominantly central in nature), honeycombing (predominantly peripheral and often in the upper zones), and a linear pattern (predominantly diffuse in nature). These patterns were recognized in 47%, 29%, and 24% of patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Alhamad

Alanezi

Idrees

et al. 2009

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVE:Sarcoidosis is prevalent worldwide with significant heterogeneity across different ethnic groups. We aimed To describe the clinical characteristics and computed tomography findings among Arab patients with pulmonary sarcoidosis.METHODS:A retrospective study of patient demographics, symptoms, co-morbid illness, sarcoidosis stage, treatment, pulmonary function and CT results.RESULTS:Of 104 patients, most (77%) were 40 years of age or older at diagnosis, and females in this category (≥40 years) significantly outnumbered male patients (69/104 (66.3%) vs. 35/104 (33.7%), P=.003). The most common complaints were dyspnea (76%), cough (72.1%) and weight loss (32.7%). The majority of patients displayed impairment in lung function parameters at presentation. However, significant impairment in forced vital capacity, percentage predicted (FVC%) (<50%) was present in only 17% of patients. The most frequent CT finding was mediastinal lymph node enlargement in 49 patients (73.1%). Parenchymal abnormalities indicating lung fibrosis were noted in 31 patients (46.3%), and traction bronchiectasis was the most common (35.8%) fibrotic pattern detected on CT scans.CONCLUSION:At presentation, clinical manifestations of sarcoidosis among this sample of Arab patients were similar to reports from other nations. Further studies are needed to explore the effects of race and ethnicity on disease severity in the Middle East.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Alhamad

Alanezi

Idrees

et al. 2009

Annals of Saudi Medicine

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“…When honeycombing is present, it is peripheral and involves the upper lung zones. (20) A pattern simulating UIP is quite rare, and, in this setting, there can be fewer granulomas than in the earlier stages of the disease. Histopathologic confirmation of sarcoidosis can be obtained through bronchial or transbronchial biopsies (positive in 60-80%), (20,21) biopsies from other sites, or, rarely, surgical lung biopsy.…”

Section: Clinical and Histopathological Correlationsmentioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

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High-resolution computed tomography (HRCT) is the radiological imaging technique best suited to revealing changes in lung structure. Various HRCT findings, taken together, can represent typical patterns. These patterns, in conjunction with the anatomical distribution of findings and with clinical data, can narrow the differential diagnosis of diffuse interstitial lung disease and, in many cases, indicate the correct diagnosis with a high degree of accuracy. The most common HRCT patterns seen in cases of diffuse interstitial lung diseases are the nodular pattern, linear/reticular opacities, cystic lesions, ground-glass opacities and consolidations. This article reviews the correlations between HRCT patterns and pathologic findings, summarizing the most common causes, as well as detailing the methods of investigation employed in order to diagnose the most common types of chronic diffuse lung disease.Keywords: Lung diseases, interstitial/pathology; Tomography, X-Ray computed; Diagnostic techniques, respiratory system. ResumoA tomografia de alta resolução (TCAR) é a técnica de imagem radiológica que reflete mais de perto as alterações da estrutura pulmonar. Os vários achados tomográficos podem ser combinados para formar padrões típicos. Estes, conjuntamente com a distribuição anatômica dos achados, e com os dados clínicos, podem estreitar o diagnóstico das doenças intersticiais pulmonares difusas, e em vários casos sugerir o diagnóstico correto com alto grau de acurácia. Os padrões mais comuns das doenças intersticiais pulmonares difusas na TCAR são o nodular, linear e reticular, lesões císticas, opacidades em vidro fosco e consolidações. Este artigo revisa as correlações entre os padrões tomográficos na TCAR e os achados patológicos e resume as causas mais comuns e os métodos de investigação para se atingir um diagnóstico nas doenças pulmonares crônicas difusas mais comuns.Descritores: Doenças pulmonares intersticiais/patologia; Tomografia computadorizada por raios X; Técnicas de diagnóstico do sistema respiratório.* Study carried out in the

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“…CMA1 genotype distributions in Dutch patients did not deviate from the healthy Dutch controls [44, 45]. …”

Section: Discussionmentioning

confidence: 99%

Chymase Gene <i>(CMA1)</i> Polymorphisms in Dutch and Japanese Sarcoidosis Patients

et al. 2006

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Background: Chymase is released from mast cells following activation. Evidence suggests that chymase plays an important role in tissue injury and remodeling of the lungs, heart and skin. Objective: We postulated that chymase gene (CMA1) polymorphisms are associated with pulmonary fibrosis in Dutch and with cardiac and skin involvement in Japanese sarcoidosis patients. Patients and Methods: Dutch (n = 153) and Japanese (n = 122) sarcoidosis patients with controls (Dutch, n = 309; Japanese, n = 111) were studied. Pulmonary involvement in Dutch patients as well as clinical manifestations in Japanese patients was evaluated for association with five CMA1 polymorphisms. Results: The CMA1 polymorphisms were not associated with disease susceptibility in either population, or with radiographic evolution in the Dutch or with cardiac or skin involvement in the Japanese patients. The –526 T allele was associated with a lower iVC in Dutch patients. Conclusions: The CMA1 polymorphisms studied do not contribute to disease susceptibility in Japanese or Dutch sarcoidosis patients. CMA1 polymorphisms do not influence radiographic evolution in Dutch sarcoidosis patients, nor do they predispose to cardiac or skin involvement in Japanese patients. However, the association between CMA1 –526 C/T and iVC in the Dutch patients suggests that chymase may modify the functional outcome of pulmonary sarcoidosis.

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Sarcoidosis with Pulmonary Fibrosis

Cited by 250 publications

References 26 publications

Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Clinical characteristics and computed tomography findings in Arab patients diagnosed with pulmonary sarcoidosis

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Chymase Gene <i>(CMA1)</i> Polymorphisms in Dutch and Japanese Sarcoidosis Patients

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