Sarcoidosis, with renal involvement

Calcium Metabolism and Bone Changes in Sarcoidosis

“…This patient's metabolism also reverted to normal during cortisone treatment, a feature observed bv Shulman et al (1952), Lovelock andStone (1953), Phillips (1953), Dent et al (1953), Lane (1954), Citron (1954Citron ( , 1955, and Anderson et al (1954). 7' Further support for the hypothesis of vitamin-D sensitivity comes from the observations on Case I and of others that treatment with this drug even in small doses or with ultra-violet light may cause hypercalcaemia (Scadding, 1950;Cantwell, 1954;Letman, 1954;Anderson et al, 1954). The recurrent symptoms of hypercalcaemia in Case 11 before calciferol was given all occurred during the summer months and were especially severe during the sunny summer of 1955.…”

“…Impairment of function may be so severe that a fatal uraemia ensues (Cantwell, 1954;Correa, 1954;Davidson et al, 1954) Hypercalcaemia may also cause band-shaped corneal opacities (Walsh and Howard, 1947;Cogan et al, 1948;Cases 1, 9, and 11), and calcification in tissues, such as the blood vessels, lungs, subcutaneous tissue, and joint capsules. In addition to these potential dangers, there is considerable doubt about the efficiency of ealciferol in the treatment of sarcoidosis.…”