Sarcoma de Ewing de la falange proximal del meñique. Reporte de caso

Soto, Camilo; Gómez, Luisa Fernanda; Criollo, Felipe; Romo, Ricardo; Messa, Óscar; Echeverri, Pablo

doi:10.1016/j.rccan.2014.04.005

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Generally, ES occurs during the second decade of life and rarely arises before 5 years of age or after 30 years of age (4). In Colombia, the incidence rate of ES is approximately 0.1 cases per 100,000 inhabitants, with similar rates in Chile, Ecuador and Costa Rica (5), while 225 cases have been reported in individuals less than 20 years of age in North America (6).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

et al. 2020

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Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra-osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS-FLI1. The epigenetic profile (histone acetylation and methylation enrichment of the promoter region) that may regulate the expression of the aberrant transcription factor EWS-FLI1, remains poorly studied and understood. Knowledge of epigenetic patterns associated with covalent histone modification and expression of enzymes associated with this process, can contribute to the understanding of the molecular basis of the disease, as well as to the identification of possible molecular targets involved in expression of the EWS-FLI1 gene, so that therapeutic strategies may be improved in the future. In the present study, the transcriptional activation and repression of the EWS-FLI1 fusion gene in ES was accompanied by selective deposition of histone markers on its promoter. The EWS-FLI1 fusion gene was evaluated in two patients with ES using conventional cytogenetic, fluorescence in situ hybridization and nested PCR assays, which revealed that the aberrant expression of the EWS-FLI1 gene is accompanied by enrichment of H3K4Me3, H3K9ac and H3K27ac at the promoter region.

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Section: Introductionmentioning

confidence: 99%

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

et al. 2020

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“…Los tumores óseos primarios representan el 5% de todos los cánceres de niños y adolescentes, el segundo más frecuente corresponde a la familia de tumores conformada por el sarcoma de Ewing clásico, tumor de Askin y tumores periféricos primitivos neuroectodérmicos (1). En Colombia la incidencia reportada es de 0.1 casos por cada 100.000 habitantes (2). Es una de las formas más agresivas de cáncer infantil y se caracteriza por mucho más común en población caucásica y por un ligero predominio en el género masculino.…”

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Sarcoma de Ewing extraesquelético de rápido crecimiento en paciente de 2 años: Reporte de caso. / Fast growing extraskeletal Ewing sarcoma in a 2 year old patient: Case report.

Monroy

Valenzuela

Chaverra

et al. 2019

Acta otorrinolaringol cir cabeza cuello

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El sarcoma de Ewing forma parte de una familia de tumores que se caracterizan por presentar translocaciones que involucran al gen EWS y algún miembro de la familia ETS que posee un dominio de unión al ADN. Se presenta el caso de un paciente de dos años de edad con una masa cervical de crecimiento rápido que por compresión local comprometió estructuras nerviosas manifestándose inicialmente con un retardo en el neurodesarrollo. Se diagnosticó Sarcoma de Ewing/Tumor neuroectodérmico primitivo por biopsia. Este es un tipo de tumor raro con una presentación inusual a nivel cervical; el cual debe tenerse en cuenta al momento de evaluar pacientes con masas cervicales en especial las de crecimiento rápido con el fin de dar un tratamiento preciso y oportuno.

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Sarcoma de Ewing de la falange proximal del meñique. Reporte de caso

Cited by 2 publications

References 13 publications

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Sarcoma de Ewing extraesquelético de rápido crecimiento en paciente de 2 años: Reporte de caso. / Fast growing extraskeletal Ewing sarcoma in a 2 year old patient: Case report.

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