Sarcoma de Kaposi con afectación colorrectal y del canal anal

Fernández, M.; Martos, María García; Moya, Patricia Sanz; Romero, Manuel Vázquez; Amago, María Teresa Fernández; Benayas, María Teresa García; Bejarano, Pilar Sánchez-Pobre

doi:10.1016/j.gastrohep.2010.05.001

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…1 Among patients with AIDS-related KS, approximately 40% of cases are found in the GI tract and are asymptomatic. 2 Some patients may develop oral lesions of the palate or gums, leading to dysphagia and subsequent infections. 1 Although rare, these lesions can present with GI bleeding, obstruction, pruritus ani, and rectal ulceration with mucous discharge.…”

Section: Presentation and Diagnosismentioning

confidence: 99%

“…KS has been described in multiple organs and anatomic locations, such as the colon, rectum, anal canal, and appendix. 2…”

Section: Introductionmentioning

confidence: 99%

“…KS has been described in multiple organs and anatomic locations, such as the colon, rectum, anal canal, and appendix. 2 KS can be classified into 4 epidemiologic variants. 3 AIDS-related KS, which can be seen at any stage of HIV infection, is the most common form in the United States.…”

Section: Introductionmentioning

confidence: 99%

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Kaposi Sarcoma of the Anus: What Does the Colorectal Surgeon Need to Know?

Fairen Oro,

Favuzza

2024

Diseases of the Colon &Amp; Rectum

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A 56-year-old woman with a history of HIV on highly active antiretroviral therapy (HAART) with a history of anal and vulvar intraepithelial neoplasia presented to the colorectal clinic for evaluation of new perianal lesions. She had an undetectable viral load and CD4 + count of 181 and was compliant with HAART. On physical examination, she had white verrucous lesions, which appeared similar to her prior condylomata acuminata as well as a purple labial lesion. Excisional biopsies were obtained of these lesions. Biopsies of the anal condylomatous lesions were consistent with anal intraepithelial neoplasia (AIN)-1 and AIN-II as well as immunohistochemistry staining positive for ERG (ETS family transcription factor ERG), CD34, and human herpes virus-8 consistent with Kaposi sarcoma (KS). The left labial lesion was also consistent with KS (Fig. 1). A staging workup was performed, including a PET-CT scan, which showed widespread metabolic uptake in multiple lymph nodes throughout her body. The left axillary lymph nodes were biopsied and positive for KS. She was referred to medical oncology and was started on liposomal doxorubicin. She completed 6 cycles over 4 months. Posttreatment imaging showed a significant decrease in disease burden and lymphadenopathy. At 3 months posttreatment, the patient was seen in the clinic and noted to have recurrent perianal condylomatous lesions. Surgical excision of these lesions revealed AIN-3 and condylomata acuminata without any evidence of recurrent KS. At her 3-month surveillance visit, she had a recurrence of condylomatous lesions, which were surgically excised and revealed AIN-1. At subsequent visits over the following 2 years, she had no further evidence of KS lesions in the perianal area. Her labial lesion also regressed completely without any recurrence (Fig. 1).

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Section: Presentation and Diagnosismentioning

confidence: 99%

“…KS has been described in multiple organs and anatomic locations, such as the colon, rectum, anal canal, and appendix. 2…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kaposi Sarcoma of the Anus: What Does the Colorectal Surgeon Need to Know?

Fairen Oro,

Favuzza

2024

Diseases of the Colon &Amp; Rectum

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“…Clinicamente, o SK Epidêmico manifesta-se por lesões cutâneas no tronco e membros inferiores, mas a diversidade de características pode levar a um atraso no diagnóstico e seu manejo inadequado 6 . Essas lesões costumam ser indolores, múltiplas, planas ou elevadas, com coloração arroxeada, castanha ou preta e que não desaparecem à digitopressão 7,8 . Podem ainda apresentar-se com edema, ulceração e sangramento.…”

Section: Relato Do Casounclassified

“…A monoquimioterapia tem menor risco de toxicidade e os mesmos benefícios da poliquimioterapia. As drogas mais usadas são doxorrubicina, bleomicina, vinblastina, paclitaxel e antraciclinas lipossomais 1,8,12 . Quanto ao HVH-8, ainda não há tratamento curativo para este agente, e o uso de anti-virais, a exemplo do ganciclovir, com propósito de redução da sua carga viral, não demonstrou eficácia 5 .…”

Section: Relato Do Casounclassified

Sarcoma de Kaposi anoperineal: uma rara apresentação

Lima¹,

Ghezzi²,

Ghezzi³

2022

CBR

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O sarcoma de Kaposi é uma neoplasia maligna associada à infecção pelo herpes vírus humano 8 em doentes imunossupressos. O sarcoma de Kaposi Epidêmico é o tipo epidemiológico mais frequente e afeta indivíduos VIH-positivos. A região anoperineal é raramente envolvida e as lesões suspeitas devem ser biopsiadas para confirmação histológica. A base do tratamento é a restauração imune do doente. Relatamos o caso de um jovem, com diagnóstico recente de infeção pelo VIH, sem tratamento, que foi admitido no serviço de infectologia apresentando sintomas constitucionais, adenomegalias inguinais e extensa lesão verrucosa e ulcerada na região anoperineal. As biópsias confirmaram o diagnóstico de sarcoma de Kaposi e o doente iniciou terapia antirretroviral e quimioterapia. Houve recuperação clínica, regressão das lesões e desaparecimento das adenomegalias. Este relato objetiva alertar as equipes médicas no sentido de se incluir o sarcoma de Kaposi no diagnóstico diferencial das lesões que afetam a região anoperineal.

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