Sarcomas in north west England: I. Histopathological peer review

Abstract

The consequences of some of these problems are exemplified in the results of the peer review studies of sarcomas which have been undertaken (Baker et al., 1978;Presant et al., 1986;Newton et al., 1988;Shiraki et al., 1989;Alvegard & Berg, 1989). In these series histological sub-type of sarcoma was frequently changed on review and significant proportions of tumours were considered ineligible as sarcomas.The study undertaken here was an attempt to define accurately the incidence of sub-types of sarcomas Grade of malignancy was not specified but in smooth muscle tumours where malignancy was equivocal, mitotic counts were performed using the criteria for malignancy recommeded by Enzinger and Weiss (1988).

Diagnostic Accuracy of MRI for Assessment of T Category, Lymph Node Metastases, and Circumferential Resection Margin Involvement in Patients with Rectal Cancer: A Systematic Review and Meta-analysis

“…In the field of pathology, for example, variability has been demonstrated in the assessment of histopathology specimens for the diagnosis or staging of numerous disease processes, both benign and malignant (114)(115)(116)(117)(118). In some instances, such discrepancies had the potential to alter clinical decisionmaking significantly.…”

Pathology Review of Cases Presenting to a Multidisciplinary Pigmented Lesion Clinic

“…The use of pathology review for other cancers, including gynecologic cancers, 7-10 testicular cancer, 11 prostate cancer, 12,13 bladder cancer, 14 lymphoma, 15 and sarcoma, 16,17 in contrast, has been repeatedly examined and justified. Interestingly, the percentage of significantly changed diagnoses reviewing these cancers ranges anywhere from 1.3% 13 to 38%.…”

Sarcomas in north west England: II Incidence

“…Studies of the incidence of sarcomas have been hampered by the use of the classification system ICD (WHO, 1978) (Fraumeni & Boice, 1982;Tucker & Fraumeni, 1982 (Harris et al, 1991). Final diagnoses were coded using ICD-O (WHO, 1976) Incidence of bone and soft tissue sarcomas overall (including visceral sarcomas) was slightly higher in females than in males but there was no sex difference when non-reviewed cases were taken into account.…”