Sarcomatoid Renal Cell Carcinoma Arising in Hemodialysis-Associated Acquired Cystic Kidney Disease Presenting With Disseminated Bone Marrow Infiltration

Suvarna, S. Kim; Ahuja, Manohar; Brown, C B

doi:10.1016/s0272-6386(12)80216-2

Cited by 14 publications

(9 citation statements)

References 16 publications

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“…Sarcomatoid RCCs account for approximately 1–8% of renal tumors, and their origination in the end‐stage kidney have been rarely reported . Sarcomatoid changes in ACD‐associated RCC are even rarer; only five cases have been documented . With respect to IHC, diffuse nuclear accumulation of p53 indicative of its gene mutation and probably related to the sarcomatoid change of RCC, was determined to be present only in the sarcomatoid component in our case.…”

Section: Discussionmentioning

confidence: 62%

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Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component

Tajima

Waki

Doi

et al. 2014

Pathology International

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Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD-associated RCC with a sarcomatoid change. The patient was a 77-year-old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from IgA nephropathy. On computed tomography, a large right RCC was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan-to-yellow tumor (95 × 75 × 55 mm) with a whitish nodule (20 × 15 × 15 mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence in situ hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the TP53 mutation.

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Section: Discussionmentioning

confidence: 62%

“…Numerical aberrations of chromosomes 3 and 16 were postulated to be important findings related to the tumorigenesis . In addition, five cases showing sarcomatoid changes have been described in the English literature, and their cytogenetic findings suggest the importance of the loss of chromosomes 9 and 14 for its development.…”

mentioning

confidence: 99%

Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component

Tajima

Waki

Doi

et al. 2014

Pathology International

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“…The tumours in ACKD are frequently low stage and low grade, but metastases and indeed deaths are described. [12][13][14][15][16] The histopathology of RCC in ACKD has attracted considerable interest recently. In the original reports and in the subsequent literature until a few years ago, these tumours were reported as being similar in histopathological appearance to sporadically occurring renal neoplasms.…”

Section: Pathology Of Renal Carcinoma Associated With Ackdmentioning

confidence: 99%

“…1,3,[17][18][19][20][21][22][23][24][25] From these publications it was suggested that clear cell carcinoma, papillary carcinoma and chromophobe carcinoma were the tumour types found, with papillary renal carcinoma over-represented in this group of patients in comparison with the general population. Oncoytoma, 20,[26][27][28][29][30] collecting duct carcinoma 31 and sarcomatoid renal carcinoma 14,32,33 have all been described mostly as isolated cases. Recent data have challenged this view and supported the existence of two tumour types specific to end-stage renal failure (ESRF) and ACKD patients.…”

Section: Pathology Of Renal Carcinoma Associated With Ackdmentioning

confidence: 99%

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Renal cell carcinoma in acquired cystic kidney disease

Fleming¹

2010

Histopathology

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There has recently been recognition of new forms of renal cell carcinoma arising in the kidneys of patients with acquired cystic kidney disease. These tumours are morphologically unique and appear to represent tumour induction in response to high levels of oxalate deposition in the kidneys. In this commentary I will review the most recent data including evidence published in Histopathology for a loop of Henle phenotype, which may be important in oxalate transport.

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Cystic renal cell carcinoma, suspected because of lack of regression of renal cysts after renal transplantation in a dialysis patient with acquired renal cystic disease

Ishikawa

Saito

Chikazawa

et al. 2003

Clinical and Experimental Nephrology

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A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was performed. Histology revealed cystic renal cell carcinoma (RCC). No case of cystic RCC occurring in a dialysis patient has previously been reported. Cystic RCC should be suspected in a cystic mass in the original kidney which does not regress after successful renal transplantation.

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Sarcomatoid Renal Cell Carcinoma Arising in Hemodialysis-Associated Acquired Cystic Kidney Disease Presenting With Disseminated Bone Marrow Infiltration

Cited by 14 publications

References 16 publications

Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component

Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component

Renal cell carcinoma in acquired cystic kidney disease

Cystic renal cell carcinoma, suspected because of lack of regression of renal cysts after renal transplantation in a dialysis patient with acquired renal cystic disease

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