Sarcomatoid Squamous Cell Carcinoma of the Penis – a Report of Two Cases

Abstract

Sarcomatoid squamous cell carcinoma of the penis is an uncommon tumor of this site with aggressive behavior and bad prognosis which might be related to the delay in medical examination and diagnosis. A correct and thorough morphological study is of great importance for the staging of the disease, treatment and follow up of patients.

Perianal Cutaneous Spindle Cell Squamous Cell Carcinoma With Myxoid Stroma: Case Report and Literature Review

“…Several cases of such lesions in the breast, larynx, vulva, penis, tibia, and other locations were reported. [2][3][4][5][6][7][8][9][10][11][12] Morphologically, all tumors in this review showed a population of poorly differentiated spindle tumor cells. No glandular structures were described.…”

“…We identified 10 articles describing 19 cases published from August 1981 to June 2022. [2][3][4][5][6][7][8][9][10][11] Collected significant data are presented in Table 1.…”

“…2 Spindle cell SCC with excessive amounts of myxoid stroma (SCSCCMS) can pose a diagnostic challenge because of its rarity, mimicry of other spindle cell skin tumors, and often lacking classic SCC morphology or in situ component. [3][4][5][6][7][8][9][10][11] We present a perianal SCSCCMS of a 74-year-old female patient with a history of metachronous clear cell renal cell carcinoma. Up to May 2022, no reports of perianal SCSCC with a large amount of myxoid stroma were published.…”

A challenging diagnosis of penile sarcomatoid squamous cell carcinoma

“…Previously reported cases have also presented as friable, pedunculated masses with notable spindlecell morphology [1]. Two separate cases of elderly men in India and Japan presented with metastases to the lungs and stomach, respectively, and resulted in death within 6 months [5,6].…”

“…Sarcomatoid carcinomas are rare, aggressive biphasic tumors that can occur anywhere on the body, rarely involving the genitourinary system, particularly the penis [1]. Typically, this entity represents one to two percent of all penile carcinomas and is considered a variant of squamous cell carcinoma (SCC).…”