Sarcomatoid Transitional Cell Carcinoma of the Renal Pelvis

López-Beltrán, Antonio; Escudero, AL; Cavazzana, Andrea; Spagnoli, Luigi Giusto; Vicioso-Recio, L.

doi:10.1016/s0344-0338(96)80154-3

Cited by 41 publications

(10 citation statements)

References 21 publications

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“…In carcinoma with spindle cell stroma [9,11], there is also a sharp demarcation between the spindle cells and the epithelial cells, but this pseudosarcomatous stromal reaction does not show an epithelial phenotype, nuclear anaplasia or aneuploidy [8]. In the present case, some sarcoma cells stained for EMA, LMWCK, broad range cytokeratin and cytokeratin 7.…”

Section: Discussionmentioning

confidence: 49%

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

et al. 2000

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A case of a man with biphasic sarcomatoid carcinoma of the right kidney with chondrosarcomatous foci and with invasion of the pelvic mucosa and submucosa into the peripelvic adipose tissue is presented. In situ carcinoma of the urothelium of the right renal pelvis and proximal ureter was also noted. Comments on the nomenclature of malignant tumours with apparently mixed carcinomatous and sarcomatous phenotypes and a hypothesis on the histogenesis of these tumours are presented. Cytokeratin and p53 protein expression patterns, and the results of angiogenesis quantification are consistent with an epithelial-to-mesenchymal conversion induced by the stroma.

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Section: Discussionmentioning

confidence: 49%

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

et al. 2000

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“…In normal kidney, CD10 is strongly expressed by the cytoplasm and membrane of podocytes and proximal tubular cell brush borders; in renal cell carcinoma CD10 is usually positive in clear cell (including eosinophilic, granular cell variant) and papillary type renal cell carcinomas (RCC). In addition to this unequivocal immunohistochemical profile, an indirect criterion for non-urothelial cell origin is the fact that the sarcomatoid component association is rather uncommon for urothelial neoplasms; very few cases have been described in the literature [15]. Sarcomatoid RCC is not very frequent either, but is still found in a significant percentage of RCC cases.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A

Herman¹,

Mantle

2017

Toxins

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Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently described London studies, augmented by clinical immunohistochemistry for the first time for this mycotoxin, establishes their renal tubular cell origin. It had been assumed that the toxin might cause the human urothelial tumours associated with Balkan endemic nephropathy, but the present study could not support this. Comparison with a similar review of a metastasising renal tumour from a female rat of the NTP study consistently shows the kidney as the primary carcinogenic site for OTA. Morphological heterogeneity of these kidney tumours as epithelioid and/or sarcomatoid is revealed. Leiomyosarcoma was also diagnosed, and rhabdomyosarcoma differentiation was observed in the exceptionally aggressive NTP female tumour. The present pilot study involving immunohistochemistry indicates need for wider review of archived tumours for experimental evidence before formulating any epidemiological basis from a rat model for OTA’s relevance to idiopathic human renal cell carcinoma. Although the NTP study concluded that females are less sensitive to OTA than males, some female tumours still had heterogeneous morphology.

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“…A poor prognosis has been reported for the majority of patients and only a few patients have survived for more than two years following diagnosis (4–8). The pathological stage may be an important factor for determining prognosis.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid carcinoma of the renal pelvis: A case report

et al. 2014

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Sarcomatoid carcinoma is a high-grade malignant neoplasm which exhibits morphological and/or immunohistochemical evidence of bidirectional epithelial and mesenchymal differentiation. Sarcomatoid carcinoma occurring in the upper urinary tract is rare. The present study reports a case of primary sarcomatoid carcinoma of the renal pelvis. A 49-year-old female patient was admitted to Beijing Chao-Yang Hospital for experiencing two weeks of intermittent hematuria. A computed tomography scan revealed a mass of 2 cm in diameter in the left renal pelvis. A retroperitoneoscopic nephroureterectomy combined with a bladder cuff excision was performed, and the final pathological diagnosis was sarcomatoid carcinoma of the renal pelvis. The patient did not receive systemic chemotherapy and radiotherapy. Regular follow-up was performed for 30 months, and there was no evidence of tumor local recurrence or distant metastasis.

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Sarcomatoid Transitional Cell Carcinoma of the Renal Pelvis

Cited by 41 publications

References 21 publications

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation

Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A

Sarcomatoid carcinoma of the renal pelvis: A case report

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