Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008–2011)

Lee, Yong-Ho; Jung, Kyu Sik; Kim, Seung Up; Yoon, Hye Jin; Yun, Yu Jung; Lee, Byung Wan; Kang, Eun Seok; Han, Kwang Hyub; Lee, Hyun Chul; Soo, Bong

doi:10.1016/j.jhep.2015.02.051

Cited by 295 publications

(333 citation statements)

References 45 publications

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“…Recent cross-sectional studies revealed the association between sarcopenia and NAFLD in general population [17][18][19]. To our knowledge, this is the first study to investigate the association between SMI and hepatic steatosis in patients with type2 diabetes.…”

Section: Discussionmentioning

confidence: 75%

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The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes

et al. 2016

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Section: Discussionmentioning

confidence: 75%

“…We obtained readings for skeletal muscle mass (SMM, kg) and visceral fat area (VFA, cm 2 ). Skeletal muscle mass index (SMI, %) was expressed as percent, dividing the SMM (kg) by total body weight (kg) [17][18][19].…”

Section: Measurement Of Body Composition Determined By Bioelectric Immentioning

confidence: 99%

The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes

et al. 2016

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“…The muscle-liver crosstalk in energy and metabolic balance is also inferred from the observation that the patients with CLD manifest a higher incidence of sarcopenia, a loss of muscle mass (20). A recent study further suggests a strong association between sarcopenia and NAFLD in both non-obese and obese subjects (29). The importance of muscle-liver crosstalk is also implicated in a transgenic animal study where genetic ablation of myostatin, a TGF-beta superfamily member that regulates skeletal muscle mass (34), ameliorated high fat diet-induced elevation of liver weight (51).…”

Section: Beneficial Effects Of Exercise On Nafldmentioning

confidence: 94%

Exercise-Induced Autophagy in Fatty Liver Disease

Chun¹,

Lee²,

Yang³

et al. 2017

Exercise and Sport Sciences Reviews

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Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.

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“…[11–14] Although the etiology of sarcopenia has not been clearly established, factors that contribute to sarcopenia, such as chronic inflammation and insulin resistance, are closely linked to renal hyperfiltration. [3,12] Furthermore, sarcopenia increases the risk of diabetes, [14] which is a determinant factor for renal hyperfiltration. [3,13] The high mortality rate of sarcopenia might be associated with renal hyperfiltration, as sarcopenia is a poor prognostic marker that is associated with increased mortality rate, independent of age, [10,11] and the U-shaped mortality curve related to kidney function.…”

Section: Introductionmentioning

confidence: 99%

Pre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance

Han

Lee

Lee³

et al. 2017

Medicine

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Renal hyperfiltration is closely linked to cardiometabolic disorders, and it may increase the mortality risk of the general population. Despite the well-established association between cardiometabolic diseases and sarcopenia, the relationship between renal hyperfiltration and sarcopenia has not yet been assessed.This population-based, cross-sectional study used a nationally representative sample of 13,800 adults from the 2008 to 2011 Korea National Health and Nutrition Examination Survey. Renal hyperfiltration was defined as the age- and sex-specific glomerular filtration rate above the 90th percentile in subjects with normal kidney function (>60 mL/min/1.73 m2). Appendicular skeletal muscle (ASM), measured by dual-energy x-ray absorptiometry, was used to assess pre-sarcopenia, which the international consensus defines as both ASM per se and ASM that was adjusted for the body mass index and the height.A total of 1402 (10.2%) participants were classified as having renal hyperfiltration. The prevalence of pre-sarcopenia ranged from 11.6% to 33.0%, by definition. Individuals with pre-sarcopenia had higher risks of renal hyperfiltration compared to those without pre-sarcopenia (10.9% vs 17.4%, P < .001; odds ratio [OR] = 1.71, 95% confidential interval [CI] = 1.48–1.99, P < .001). Multiple logistic regression analyses also demonstrated this independent association between pre-sarcopenia and renal hyperfiltration, following adjustment for confounding factors such as insulin resistance and obesity (OR = 1.84, 95% CI = 1.57–2.15, P < .001).In the general population of healthy individuals, pre-sarcopenia might be associated with renal hyperfiltration independent of obesity or insulin resistance.

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Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008–2011)

Cited by 295 publications

References 45 publications

The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes

The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes

Exercise-Induced Autophagy in Fatty Liver Disease

Pre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance

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