Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement

Damluji, Abdulla; Rodriguez, Gregory; Noel, Thomas; Davis, Lakerria; Dahya, Vishal; Tehrani, Behnam; Epps, Kelly; Sherwood, Matthew W.; Sarin, Eric L.; Walston, Jeremy D.; Bandeen‐Roche, Karen; Resar, Jon R.; Brown, Todd T.; Gerstenblith, Gary; O’Connor, Christopher M.; Batchelor, Wayne

doi:10.1016/j.ahj.2020.03.021

Cited by 25 publications

(17 citation statements)

References 43 publications

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“…There remains no standardized cut-off value for dividing populations into sarcopenic and non-sarcopenic groups. Damluji et al (2020) used absolute sex-specific cutoffs (women: SMI < 39 cm 2 /m 2 ; men: < 55 cm 2 /m 2 ) 23 while Yoon et al (2021) analyzed sarcopenic patients based on SMI tertiles 24 . This heterogeneity led us to explore different methods for quantifying sarcopenia from psoas area.…”

Section: Comparison To Existing Literaturementioning

confidence: 99%

Association Between Sarcopenia and Adverse Events Following Transcatheter Aortic Valve Implantation

Brown

Gabriel

et al. 2022

CJC Open

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Section: Comparison To Existing Literaturementioning

confidence: 99%

Association Between Sarcopenia and Adverse Events Following Transcatheter Aortic Valve Implantation

Brown

Gabriel

et al. 2022

CJC Open

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“…16,[18][19][20] To discuss the results, prevalence of severe sarcopenia was assessed using the other previous total skeletal muscle index thresholds. [13][14][15][16][17][18][19][20][21]…”

Section: Baseline Datamentioning

confidence: 99%

“…In the literature, some studies highlighted the impact of sarcopenia on the increase in mortality, rehospitalization or high resource utilization after TAVR, while others found diverging results. [13][14][15][16][17][18][19][20][21] But none of these studies included a complete geriatric assessment with physical performance and complete nutritional assessment. The main purpose of our study was to evaluate the impact of severe sarcopenia on rehospitalization and survival one year after a TAVR procedure in patients aged 75 years and older.…”

Section: Introductionmentioning

confidence: 99%

Impact of Severe Sarcopenia on Rehospitalization and Survival One Year After a TAVR Procedure in Patients Aged 75 and Older

Brouessard¹,

Bobet²,

Mathieu³

et al. 2021

CIA

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Background: Transcatheter aortic-valve replacement (TAVR) reduces mortality and improves quality of life in patients with severe aortic valve stenosis. One third of patients have no benefit one year after TAVR. Sarcopenia, an age-related loss of skeletal muscle mass, is associated with increased physical disability and mortality. The main purpose was to evaluate the impact of severe sarcopenia on rehospitalization one year after TAVR in older patients. Methods: All patients aged ≥75 referred for a TAVR in 2018 were included. Severe sarcopenia was defined by a loss of skeletal muscle mass defined on CT-scan measurement associated with a gait speed ≤0.8m/s. The main outcome was rehospitalization one year after TAVR. Results: Median age of the 182 included patients was 84, and 35% had an unplanned hospitalization at one year. Severe sarcopenia was diagnosed in 9 patients (4.9%). Univariable analysis showed that gait speed was a factor associated with readmission [HR=0.32, 95% CI (0.10-0.97), p=0.04] but not severe sarcopenia. In multivariable analysis, only diabetes was significantly associated with rehospitalization [HR=2.06, 95% CI (1.11-3.84), p=0.02]. Prevalence of severe sarcopenia varied according to different thresholds of skeletal muscle mass on CT-scan. Conclusion: Even though severe sarcopenia was not correlated with rehospitalization and mortality at one year after TAVR, our results emphasize the changes in the prevalence according to cutoff used. It highlights the need to define standardized methods and international threshold for sarcopenia diagnosis by CT-scan measurements, in general population and for patients with valvular heart disease.

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“…Among the many methods available to assess muscle status, the measurement of psoas muscle area (PMA) using computed tomography (CT) is well known. Reports have related PMA to mortality and the quality of life in several critical patients [ 7 , 10 , 19 ]. CT measurement of the masseter muscle area (MMA) is an alternative method to analyze muscle status.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Analysis of the Association of Psoas and Masseter Muscles with Traumatic Brain Injury Using Computed Tomography Anthropometry

Cho

Hwang

Yang

et al. 2021

J Korean Neurosurg Soc

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Objective : Psoas and masseter muscles are known markers of sarcopenia. However, the relative superiority of either muscle as a marker is unclear. Therefore, this study analyzed the two muscles in patients with a prognosis of traumatic brain injury (TBI). Methods : Patients with TBI visiting a regional trauma center between January 2017 and December 2018 were selected, and their medical records were reviewed. TBI patients with an abbreviated injury score (AIS) of 4 or 5 were selected. Patients with an AIS of 4 or 5 at the chest, abdomen, and extremity were excluded. Patients with a hospital stay of 1 to 2 days were excluded. Both muscle areas were measured based on the initial computed tomography. The psoas muscle index (PMI) and the masseter muscle index (MMI) were calculated by dividing both muscle areas by height in meters squared (cm 2 /m 2 ). These muscle parameters along with other medical information were used to analyze mortality and the Glasgow outcome scale (GOS). Results : A total of 179 patients, including 147 males (82.1%), were analyzed statistically. The mean patient age was 58.0 years. The mortality rate was 16.8% (30 patients). The mean GOS score was 3.7. Analysis was performed to identify the parameters associated with mortality, which was a qualitative study outcome. The psoas muscle area (16.9 vs. 14.4 cm 2 , p=0.028) and PMI (5.9 vs. 5.1 cm 2 /m 2 , p=0.004) showed statistical differences between the groups. The PMI was also statistically significant as a risk factor for mortality in logistic regression analysis (p=0.023; odds ratio, 0.715; 95% confidence interval, 0.535-0.954). Quantitative analyses were performed with the GOS scores. Bivariate correlation analysis showed a statistically significant correlation between PMI and GOS scores (correlation coefficient, 0.168; p=0.003). PMI (p=0.004, variation inflation factor 1.001) was significant in multiple regression analysis. The masseter muscle area and MMI did not show significance in the study. Conclusion : Larger PMI was associated with statistically significant improved survival and GOS scores, indicating its performance as a superior prognostic marker. Further analyses involving a larger number of patients, additional parameters, and more precise settings would yield a better understanding of sarcopenia and TBI.

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Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement

Cited by 25 publications

References 43 publications

Association Between Sarcopenia and Adverse Events Following Transcatheter Aortic Valve Implantation

Association Between Sarcopenia and Adverse Events Following Transcatheter Aortic Valve Implantation

Impact of Severe Sarcopenia on Rehospitalization and Survival One Year After a TAVR Procedure in Patients Aged 75 and Older

A Comprehensive Analysis of the Association of Psoas and Masseter Muscles with Traumatic Brain Injury Using Computed Tomography Anthropometry

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