Sarcopenia and two types of presarcopenia in Japanese patients with chronic liver disease

Hiraoka, Atsushi; Michitaka, Kojiro; Ueki, Hidetaro; Kaneto, Miho; Aibiki, Toshihiko; Okudaira, Taeko; Kawakami, Takamasa; Yamago, Hiroka; Suga, Yasuhiro; Tomida, Hideomi; Miyamoto, Yuji; Azemoto, Nobuaki; Mori, Kenichiro; Miyata, Hideki; Tsubouchi, Eiji; Nakamura, Tomoyuki; Hirooka, Masashi; Abe, Masanori; Matsuura, Bunzo; Hiasa, Yoichi

doi:10.1097/meg.0000000000000661

Cited by 64 publications

(67 citation statements)

References 25 publications

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“…As noted in a previous report, the present results noted gender differences in regard to the test results. We found that a finger‐circle test result in male patients other than Bigger (Just‐fits and Smaller) predicted a decline in muscle area of L3 to PI 5.25 cm 2 /m 2 , which was approximately mean minus 1 SD (5.37 cm 2 /m 2 ).…”

Section: Discussionsupporting

confidence: 87%

“…However, it is important to keep in mind that there are discrepancies between actual clinical practice and reported guidelines. There might be gender differences concerning to progressions of MA and MSD . Moreover, although there was no significance in increasing the percentage of sarcopenia in each stage of CLD in the present cohort ( n = 358; CH vs. LC CP‐A, vs. LC CP‐B/C = 5.8% vs. 8.3% vs. 15.4%; P = 0.110), progression of CLD stage is an important risk factor for existence of muscle abnormality .…”

Section: Discussioncontrasting

confidence: 62%

“…Furthermore, muscle function loss has been reported to have a close relationship with cognitive function . It has been reported that percentage of muscle abnormality became larger and larger statistically with progression of CLD stage in past analyses with large number of CLD patients over 800 individuals . Both conditions are related to lower quality of life and worse survival; thus, it is important for CLD patients to maintain muscle volume and function.…”

Section: Discussionmentioning

confidence: 99%

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Easy surveillance of muscle volume decline in chronic liver disease patients using finger‐circle (yubi‐wakka) test

Hiraoka

Izumoto

Ueki

et al. 2019

J cachexia sarcopenia muscle

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Background Muscle atrophy (MA) and muscle strength decline are important clinical features in chronic liver disease (CLD) patients. An easy to perform MA screening method without need for special equipment would be helpful. We evaluated the usefulness of the previously reported finger‐circle test as screening for MA in CLD patients. Methods We retrospectively enrolled 358 Japanese CLD outpatients (70.8 ± 10.2 years, male/female = 234/124) who had undergone a computed tomography examination from December 2017 to March 2018, of whom 137 had chronic hepatitis, 169 had liver cirrhosis Child–Pugh A, and 52 had liver cirrhosis Child–Pugh B/C. Bilateral psoas muscle area at the middle of the third lumber vertebra (L3) was evaluated with computed tomography findings, which was performed as a screening of hepatocellular carcinoma, using a previously reported parameter for MA [psoas index (PI): total psoas muscle area (cm 2 )/height (m) 2 ] [mean PI ± standard deviation (SD) of male patients: 6.50 ± 1.13 cm 2 /m 2 and those of female patients: 4.30 ± 0.90 cm 2 /m 2 ]. We then evaluated the correlation between MA and finger‐circle test results in these patients. Results The mean PI values for finger‐circle test results Bigger, Just‐fits, and Smaller were 5.64 ± 1.34, 5.00 ± 1.25, and 4.83 ± 1.46 cm 2 /m 2 , respectively, in male patients ( P < 0.001) and 4.31 ± 1.06, 3.93 ± 0.97, and 3.42 ± 0.94 cm 2 /m 2 , respectively, in female patients ( P = 0.001). We found that a finger‐circle test result in male patients other than Bigger (Just‐fits and Smaller) predicted a decline in psoas muscle area of L3 to PI 5.25 cm 2 /m 2 (sensitivity/specificity 0.619/0.667, area under the curve 0.654, 95% confidence interval 0.583–0.724), which was approximately mean minus 1 SD (5.37 cm 2 /m 2 ). On the other hand, a Smaller test result in female patients predicted a decline in psoas muscle area of L3 to PI 3.33 cm 2 /m 2 (sensitivity/specificity 0.740/0.583, area under the curve 0.698, 95% confidence interval 0.583–0.813), approximately mean minus 1 SD (3.40 cm 2 /m 2 ). Conclusions The finger‐circle test is an easy to perform and effective screening method for predicting earlier stage of MA in CLD patients without the need for special equipment.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Easy surveillance of muscle volume decline in chronic liver disease patients using finger‐circle (yubi‐wakka) test

Hiraoka

Izumoto

Ueki

et al. 2019

J cachexia sarcopenia muscle

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“…European Working Group on Sarcopenia in Older People, AWGS, and JSH have defined sarcopenia as MVL coexisting with muscle strength decline. In patients with CLD, sarcopenia, MVL, and muscle strength decline are not rare, even in an early stage . In addition, MVL has recently been reported as a prognostic factor for survival in HCC patients treated with liver transplantation, surgical resection, or sorafenib, although few reports have elucidated the relationship between muscle function and prognosis of HCC patients following surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Impact of muscle volume and muscle function decline in patients undergoing surgical resection for hepatocellular carcinoma

Hiraoka

Otsuka

Kawasaki

et al. 2018

J of Gastro and Hepatol

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“…Therefore, the prevalence of sarcopenia in previous studies may have been underestimated. Hiraoka et al . reported that the prevalence of sarcopenia in patients with chronic hepatitis and liver cirrhosis was 3.9–16.7% when sarcopenia was defined based on the psoas muscle index at the L3 level on CT and based on declined grip strength.…”

Section: Discussionmentioning

confidence: 99%

Validity of Japanese version of SARC‐F questionnaire in patients with chronic liver disease

Ida

Kojima

Hamaoka

et al. 2018

J of Gastro and Hepatol

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Sarcopenia and two types of presarcopenia in Japanese patients with chronic liver disease

Abstract: Evaluation of handgrip strength and psoas index is an easy and effective method for the detection of sarcopenia and presarcopenia.

Cited by 64 publications

References 25 publications

Easy surveillance of muscle volume decline in chronic liver disease patients using finger‐circle (yubi‐wakka) test

Easy surveillance of muscle volume decline in chronic liver disease patients using finger‐circle (yubi‐wakka) test

Impact of muscle volume and muscle function decline in patients undergoing surgical resection for hepatocellular carcinoma

Validity of Japanese version of SARC‐F questionnaire in patients with chronic liver disease

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