Sarcopenia as a predictor of pulmonary complications after esophagectomy for thoracic esophageal cancer

Nishigori, Tatsuto; Okabe, Hiroshi; Tanaka, Eiji; Tsunoda, Shigeru; Hisamori, Shigeo; Sakai, Yoshiharu

doi:10.1002/jso.24214

Cited by 148 publications

(94 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, there is significant evidence showing that sarcopenia is independently associated with poor response to cancer therapy in pancreatic (18), breast (19), colorectal (13,20), and renal-cell (21), and hepatic (22) cancer. Sarcopenia carries a high risk of morbidity (23)(24)(25)(26) and confers poor long-term survival after resection of esophageal cancer (27)(28)(29) chemoradiotherapy and esophageal resection cases (7). To our knowledge, our retrospective study is the first report that shows the impact of sarcopenia on patients with unresectable locally advanced esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Sato

Kunisaki

Suematsu

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Sato

Kunisaki

Suematsu

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Decreased muscle mass, assessed by preoperative computed tomography scans, seems to be an independent predictor of both overall survival (Figure 1) [44] and disease-free survival, as significant as tumor stage, in patients following esophagectomy [45,46]. In addition, sarcopenic patients who underwent esophagectomy had significantly higher rate of respiratory complications compared to nonsarcopenic subjects, but there was no difference in the incidence of overall complications between the two groups [47][48][49]. Sarcopenia has also impact on chemotherapy outcome since decreased muscle mass is associated with dose-limiting toxicity and pathological chemotherapy response in patients receiving neoadjuvant chemotherapy [50][51][52].…”

Section: Sarcopenia and Cancer Cachexiamentioning

confidence: 98%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

View full text Add to dashboard Cite

Esophageal cancer is associated with malnutrition in the vast majority of patients. This phenomenon is partly attributed to the disease process itself, the location of the tumor and other factors, such as dysphagia which is often accentuated due to chemotherapy/ radiotherapy treatment or surgical intervention. The poor nutritional status of these patients is often related to the presence of cancer cachexia, altered metabolism, and tissue wasting. Malnutrition in this patient population affects quality of life, worsens patient's tolerance to chemotherapy and accounts for lower survival. Nutritional management of these patients includes both proper nutritional assessment and support and might prevent, to a certain extent, the manifestation of malnutrition-related consequences. The purpose of this article is to review the current literature in order to focus on the etiology and diagnosis of malnutrition in esophageal cancer patients, emphasizing also on the optimal nutritional support during multimodality treatment.

show abstract

“…The presence of sarcopenia was reported to be associated with postoperative complications or poor prognosis in patients with diverse types of cancer [9][10][11]. Some investigators found that sarcopenia was a predictor of postoperative complications after esophagectomy [12][13][14]. However, few studies have analyzed the association between postoperative complications and sarcopenia in patients with esophageal cancer treated with neoadjuvant therapy followed by surgery.…”

Section: Introductionmentioning

confidence: 98%

Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer

et al. 2018

View full text Add to dashboard Cite

Objective: Neoadjuvant therapy followed by surgery has been the standard treatment for advanced esophageal cancer. Severe toxicities may influence body composition, including skeletal muscle mass, and increase postoperative complications. The purpose of this study was to evaluate the influence of sarcopenia, changes in body composition, and adverse events during neoadjuvant chemotherapy (NACT) on postoperative complications in esophageal cancer patients. Methods: A total of 83 patients with esophageal cancer undergoing NACT followed by esophagectomy were included. Body composition was assessed before chemotherapy and before esophagectomy. The relationships between postoperative infectious complications and sarcopenia, changes in body composition, and adverse events during NACT were investigated. Results: Univariate analysis revealed that skeletal muscle loss during NACT, but not preoperative sarcopenia, was significantly higher in the complication (+) group. Febrile neutropenia tended to occur frequently in the complication (+) group. Multivariate analysis demonstrated that skeletal muscle loss was the only factor significantly associated with infectious complications (p = 0.029). Among adverse events, febrile neutropenia was significantly associated with a decrease in skeletal muscle mass. Conclusion: Loss of skeletal muscle mass during NACT was a significant risk factor for postoperative infectious complications in patients with esophageal cancer. Prevention of severe adverse events may reduce postoperative infectious complications.

show abstract

Sarcopenia as a predictor of pulmonary complications after esophagectomy for thoracic esophageal cancer

Abstract: Sarcopenia independently predicts pulmonary complications after esophagectomy for thoracic esophageal cancer. J. Surg. Oncol. 2016;113:678-684. © 2016 Wiley Periodicals, Inc.

Cited by 148 publications

References 77 publications

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy

Nutritional Management of Esophageal Cancer Patients

Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer

Contact Info

Product

Resources

About