Sarcopenia hinders the decline in disease activity after surgery for people with Crohn's disease: Preliminary results

Yasueda, Asuka; Sekido, Yuki; Takeda, Takashi; Ogino, Takayuki; Miyoshi, Norikatsu; Takahashi, Hidekazu; Uemura, Mamoru; Doki, Yuichiro; Eguchi, Hidetoshi; Mizushima, Tsunekazu

doi:10.1016/j.nut.2021.111526

Cited by 13 publications

(12 citation statements)

References 36 publications

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“…Yasueda et al . used PMI thresholds of 6.36 and 3.92 cm 2 /m 2 for men and women, respectively, which were derived from a cohort of Japanese adults for living donor liver transplantation 14 . We used both thresholds from Pedersen et al .…”

Section: Methodsmentioning

confidence: 99%

“…7 Yasueda et al used PMI thresholds of 6.36 and 3.92 cm 2 /m 2 for men and women, respectively, which were derived from a cohort of Japanese adults for living donor liver transplantation. 14 We used both thresholds from Pedersen et al and Yasueda et al for analysis of our PMI thresholds. 7,14 We avoided using area thresholds which were not adjusted to height for total skeletal muscle and psoas muscle areas acknowledging the importance of adjustment to height.…”

Section: Sarcopenia Measurementmentioning

confidence: 99%

“…14 We used both thresholds from Pedersen et al and Yasueda et al for analysis of our PMI thresholds. 7,14 We avoided using area thresholds which were not adjusted to height for total skeletal muscle and psoas muscle areas acknowledging the importance of adjustment to height.…”

Section: Sarcopenia Measurementmentioning

confidence: 99%

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Sarcopenia measurements and clinical outcomes in Crohn's disease surgical patients

Hong

Liu

Tran

et al. 2022

ANZ Journal of Surgery

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Background Patients with Crohn's disease (CD) have a high likelihood of being sarcopenic. Several studies have shown a positive correlation between sarcopenia measured as skeletal muscle index (SMI) and poor surgical outcomes in patients with CD. Our primary aim was to correlate SMI with the psoas muscle index (PMI), an easier measurement of sarcopenia. Secondary aim was to correlate SMI and PMI with clinical outcomes in a cohort of CD patients requiring surgery. Methods A retrospective cohort study of CD patients who underwent surgery at a public health service from January 2010 to December 2019. Using computed tomography and magnetic resonance enterography studies, skeletal muscle area was measured at the third lumbar vertebra level. SMI and PMI were calculated and correlated. Correlation between SMI and PMI with surgical outcomes was performed. Results Seventy‐six patients were included. Median length of stay (LOS) was 6 days (IQR, 5 to 9). Eleven patients (14.5%) required ICU admission, nine patients (11.8%) required TPN and thirteen patients (17.1%) had complications. The prevalence of sarcopenia was 63.2% based on the SMI threshold of 52.4 and 38.5 cm2/m2 for men and women, respectively. A positive correlation between SMI and PMI was found (r = 0.72, P < 0.0001). Sarcopenia status based on reported thresholds for SMI and for PMI showed no significant correlation with outcomes (LOS, ICU admission and complications). Conclusions SMI and PMI show good correlation but there is insufficient evidence to suggest that sarcopenia status using either measurement has a significant impact on predicting clinical outcomes.

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Section: Methodsmentioning

confidence: 99%

Section: Sarcopenia Measurementmentioning

confidence: 99%

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Sarcopenia measurements and clinical outcomes in Crohn's disease surgical patients

Hong

Liu

Tran

et al. 2022

ANZ Journal of Surgery

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“…There were 16 studies (1,589 patients, age 17.9 to 43.8 years). 27,29,30,35,38,44,46,47,69,79,95,99,110,115,118,135 Ten studies specifically were related to Crohn's disease (►Table 6). One study assessed the feasibility of MRI for the detection of skeletal muscle mass.…”

Section: Sarcopenia and Inflammatory Bowel Diseasementioning

confidence: 99%

Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review

Farook

Soni

Shantagiri

et al. 2023

Journal of Gastrointestinal and Abdominal Radiology

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Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life, and death. The diagnosis of sarcopenia is based on documentation of two of the three criteria: low muscle mass, low muscle strength, and low physical performance. Imaging-based assessment of muscle mass is preferred in both clinical and research settings. Anthropometry for the evaluation of muscle mass is prone to errors and is not recommended in the clinical setting.There is a lack of literature on the radiological assessment of sarcopenia and its association with prognosis in hepatobiliary, pancreatic, and gastrointestinal diseases. Thus, we aim to provide a review of studies that utilized radiological methods to assess sarcopenia and evaluate its impact on outcomes in patients with these diseases.

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“…Some studies concluded that there were no signi cant differences in gender, age, Montreal location, behavioral typing, disease activity index and in ammatory marker between patients with and without combined sarcopenia [10]. However, other studies have suggested that C-reactive protein (CRP) is positively associated with the development of sarcopenia and that L2 type is an independent risk factor for sarcopenia [11,12].…”

Section: Introductionmentioning

confidence: 99%

The association between hemoglobin level and sarcopenia in patients with Crohn's disease

Liu

Gao

et al. 2023

Preprint

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Sarcopenia and anemia are common complication in patients with Crohn's Disease (CD). However, few studies have showed the association between sarcopenia and hemoglobin level in patients with CD. This study aimed to explore such association in a Chinese population with CD. Two hundreds and twelve adult CD inpatients who underwent computed tomography (CT) or magnetic resonance imaging (MRI) examinations from July 2019 to December 2021 were included. Sarcopenia was defined according to the cutoff value of skeletal muscle index of lumbar spine 3 (SMI-L3) (< 44.77cm2/m2 for male and < 32.5cm2/m2 for female). The inpatients with CD were divided into two groups based on the presence or absence of sarcopenia. The clinical data, hemoglobin levels and other laboratory data were retrospectively collected. The association between hemoglobin levels and sarcopenia were identified through univariate and multivariate logistic regression analysis. Sarcopenia occurred in 114 CD patients (53.8%). Compared to patients without sarcopenia, patients with sarcopenia had significantly lower proportion of L1 (30.7% vs 45.8%, p = 0.032) and B1 classification (58.8% vs 72.4%, P = 0.037). Patients with sarcopenia had significant lower level of hemoglobin (Hb) (116.5 ± 22.8 vs 128.1 ± 21.0, p < 0.001). The prevalence of sarcopenia increased with the decrease of hemoglobin level (p for trend < 0.05). Linear regression analysis showed that hemoglobin levels were associated to SMI-L3 (β = 0.091, p = 0.001). Multivariate logistic regression analysis found that higher Hb (OR:0.98; 95% CI: 0.96,0.99; p = 0.034) were independent associated factors for sarcopenia. Lower Hb levels are independent associated factors of sarcopenia in adult inpatients with CD.

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Sarcopenia hinders the decline in disease activity after surgery for people with Crohn's disease: Preliminary results

Cited by 13 publications

References 36 publications

Sarcopenia measurements and clinical outcomes in Crohn's disease surgical patients

Sarcopenia measurements and clinical outcomes in Crohn's disease surgical patients

Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review

The association between hemoglobin level and sarcopenia in patients with Crohn's disease

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