Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia

Chen, Liang Kung; Liu, Li Kuo; Woo, Jean; Assantachai, Prasert; Auyeung, Tung Wai; Bahyah, Kamaruzzaman Shahrul; Chou, Ming Yueh; Chen, Liang Yu; Hsu, Pi Shan; Krairit, Orapitchaya; Lee, Jenny S.W.; Lee, Wei Ju; Lee, Yunhwan; Liang, Chih‐Kuang; Limpawattana, Panita; Lin, Ching-Cheng; Peng, Li Ning; Satake, Shosuke; Suzuki, Takao; Won, Chang Won; Wu, Chih Hsing; Wu, Si; Zhang, Teimei; Zeng, Ping; Akishita, Masahiro; Arai, Hidenori

doi:10.1016/j.jamda.2013.11.025

Cited by 3,413 publications

(3,431 citation statements)

References 68 publications

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“…A previous study defined sex‐specific cut‐offs for low skeletal muscle mass as more than 2 SDs below the means of young adults 37. In addition, the Asian Working Group for Sarcopenia has also recommended using 2 SDs below the mean muscle mass of a young reference group or the lower quintile when determining cut‐offs 38. In the present study, SMI, IMAC, and VSR differed significantly between younger (<50 years) and older (≥50 years) donors.…”

Section: Discussionmentioning

confidence: 99%

Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation

Hamaguchi

Kaido

Okumura

et al. 2018

J cachexia sarcopenia muscle

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BackgroundThe significance of pre‐operative body composition has recently attracted much attention in various diseases. However, cut‐off values for these parameters remain undetermined, and these factors are not currently included in selection criteria for recipients of living donor liver transplantation (LDLT).MethodsUsing computed tomography of 657 donors for LDLT, skeletal muscle mass, muscle quality, and visceral adiposity were evaluated by using skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), and visceral‐to‐subcutaneous adipose tissue area ratio (VSR). Sex‐specific cut‐offs for SMI, IMAC, and VSR were determined, and correlations with outcomes after LDLT in 277 recipients were examined with the aim of establishing new selection criteria for LDLT.ResultsOn the basis of younger donor data, we determined sex‐specific cut‐off values for low SMI, high IMAC, and high VSR (mean ± 2 standard deviations). Patients with all three factors showed the lowest survival rate after LDLT (1 year survival rate, 41.2%; P < 0.001). On multivariate analysis, low SMI (P = 0.002), high IMAC (P = 0.002), and high VSR (P = 0.001) were identified as independent risk factors for mortality after LDLT. Based on these findings, we have excluded patients showing all three factors (low SMI, high IMAC, and high VSR) as candidates for LDLT since October 2016.ConclusionsUsing cut‐off values determined from healthy donors, we have established new selection criteria for LDLT including body composition, which should improve post‐transplant outcomes.

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Section: Discussionmentioning

confidence: 99%

Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation

Hamaguchi

Kaido

Okumura

et al. 2018

J cachexia sarcopenia muscle

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“…Sarcopenia was defined using the Asian Working Group for Sarcopenia criteria, employing recommended gender specific cut-off values for muscle mass as measured on DXA, as well as grip strength and gait speed (Chen et al 2014). …”

Section: Muscle and Fat Measuresmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

140

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With considerable variation including potential sex-specific differential rate of skeletal muscle loss, identifying modifiable factors for sarcopenia will be pivotal to guide targeted interventions. This study seeks to identify clinical and biological correlates of sarcopenia in community-dwelling older adults, with emphasis on the role of anabolic and catabolic stimuli, and special reference to gender specificity. In this crosssectional study involving 200 community-dwelling and functionally independent older adults aged ≥50 years, sarcopenia was defined using the Asian Working Group for Sarcopenia criteria. Comorbidities, cognitive and functional performance, physical activity and nutritional status were routinely assessed. Biochemical parameters included haematological indices, lipid panel, vitamin D level, anabolic hormones [insulin-like growth factor-1 (IGF-1), free testosterone (males only)] and catabolic markers [inflammatory markers (interleukin-6, Creactive protein) and myostatin]. Multiple logistic regression was performed to identify independent predictors for sarcopenia. Age was associated with sarcopenia in both genders. Malnutrition conferred significantly higher odds for sarcopenia in women (OR=5.71, 95 % CI 1.13-28.84.44, p=0.035) while higher but acceptable range serum triglyceride was protective in men (OR=0.05, 95 % CI 0.00-0.52, p=0.012). Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR=1.11, 95 % CI 1.00-1.24, p=0.041). Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p=0.095). Our findings support differential pathophysiological mechanisms for sarcopenia that, if corroborated, may have clinical utility in guiding sex-specific targeted interventions for community-dwelling older adults.

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“…Although sarcopenia was originally estimated based on appendicular skeletal muscle mass 22) , the current criteria of sarcopenia remains varied. The current consensus in Asia and Europe regarding the definition of sarcopenia includes a loss of grip strength and/or walking speed in the criteria 23,24) . In addition, physical frailty, which is considered a high-risk factor for physical disability, hospitalization, and mortality, is characterized by weakness (grip strength) as part of its definition 25) .…”

Section: Validity As a Predictor Of Geriatric Concernsmentioning

confidence: 99%

“…In Japan, the cut-off points of 26 kg in men and 18 kg in women for preventing geriatric syndromes, as suggested by the Asian Working Group for Sarcopenia 24) , may be the most widely accepted. At the threshold point of impaired physical capacity, lower limits are more serious in women.…”

Section: Grip Strength Cut-off Valuesmentioning

confidence: 99%

Grip strength and healthy aging

Kozakai

2017

JPFSM

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Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia

Cited by 3,413 publications

References 68 publications

Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation

Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Grip strength and healthy aging

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