Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

Bhanji, Rahima A.; Montano‐Loza, Aldo J.; Watt, Kymberly D.

doi:10.1002/hep.30686

Cited by 63 publications

(72 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…cirrhotic patients (16)(17)(18)(19)(20). In the present study, we showed that the physical data automatically estimated with the BIA method correlated well with the directly measured physical data and were related to the prognosis of the cirrhotic patients as well the directly measured anthropometric data.…”

Section: Discussionsupporting

confidence: 67%

The Anthropometric Assessment With the Bioimpedance Method Is Associated With the Prognosis of Cirrhotic Patients

Moriwaki

Enomoto

Saito

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: The bioimpedance analysis (BIA) can provide anthropometric data on patients. The aim of the study is to evaluate the clinical relevance of these automatically obtained values. Patients and Methods: We studied the arm circumference (AC) and arm muscle circumference (AMC) of 197 histologically proven cirrhotic patients. The BIA-based anthropometric data were compared to the manually measured data. In addition, we evaluated whether or not the BIA-based anthropometric data were associated with the prognosis of the patients. Results: The data of %AC and %AMC obtained using the two methods were well correlated (p<0.001) with relatively inconspicuous differences (approximately 6.0% for %AC and 16.0% for %AMC). The data of %AC and %AMC obtained from the BIA method were significantly associated with the prognosis of the patients. Conclusion: The BIA-based anthropometric data were associated with the direct measurement data and related to the prognosis of cirrhotic patients.

show abstract

Section: Discussionsupporting

confidence: 67%

The Anthropometric Assessment With the Bioimpedance Method Is Associated With the Prognosis of Cirrhotic Patients

Moriwaki

Enomoto

Saito

et al. 2020

In Vivo

View full text Add to dashboard Cite

show abstract

“…In patients with cirrhosis, Kazemi-Bajesti showed that sarcopenia was more prevalent in patients with low left ventricular mass [59]. Cardiac sarcopenia was recently defined by the loss of cardiomyocytes resulting in impaired cardiac function in the absence of any cardiovascular disease [60].…”

Section: Is Cardio-respiratory Sarcopenia Frequent In Patients With Cmentioning

confidence: 99%

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

et al. 2020

View full text Add to dashboard Cite

Malnutrition is a common comorbidity in patients with cirrhosis. Its prognostic value is indisputable as it greatly affects the evolution of liver diseases. It has a major impact on both morbi-mortality before and after liver transplantation. Being now integrated in the definition of malnutrition and recognized as a new entity in the international classification of diseases, physicians have taken great interest in sarcopenia. Its negative consequences on the fate of patients with cirrhosis are well-demonstrated. The concept of frailty has recently been enlarged to chronic liver diseases as symptoms of impaired global physical functioning. In this article, we will discuss the definitions of malnutrition and emphasize its links with sarcopenia and frailty. We will show the relevance of frailty and sarcopenia in the course of liver diseases. The emerging role of muscle depletion on the cardiorespiratory system will also be highlighted. The importance of body composition will be demonstrated and the main tools reviewed. Finally, we adapted the definition of malnutrition to patients with cirrhosis based on the assessment of sarcopenia together with reduced food intakes.

show abstract

“…Japanese CLD patients are aging these days, and it is also an important public health problem as aging can be associated with sarcopenia [10,11]. How sarcopenia is associated with such adverse clinical outcomes needs to be looked at beyond the overt muscle mass loss or muscle strength decline and at this clinical entity as a systemic disease [12][13][14]. Muscle mass has been assessed by different techniques such as the bioimpedance analysis (BIA), dual-energy X-ray, computed tomography (CT) and magnetic resonance imaging, and the functional consequence of sarcopenia is estimable by handgrip strength (HGS) or other more composite tests such as the walking test [10,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Walking Speed: Japanese Data in Chronic Liver Diseases

Nishikawa

Enomoto

Iwata

et al. 2020

JCM

View full text Add to dashboard Cite

We aim to clarify the impact of walking speed (WS) and analyze factors linked to WS decline in patients with chronic liver diseases (CLDs, 165 males and 191 females, 137 liver cirrhosis patients). The WS decline is defined as <0.8 m/second (m/s), referring to the guidelines. The median (range) WS was 1.3 m/s (0.2–2.02 m/s). There were 17 patients with WS < 0.8 m/s (4.8%). The WS value was significantly correlated with the handgrip strength value both in males (r2 = 0.252, p < 0.0001) and females (r2 = 0.256, p < 0.0001). In the multivariate analysis of factors associated with WS decline, only the extracellular water (ECW) to total body water (TBW) ratio using bioimpedance analysis was an independent predictor (p = 0.0398). Extracellular fluid excess was categorized as follows: normal condition (ECW to TBW ratio < 0.390), mild overhydrated condition (ECW to TBW ratio 0.390–0.399), and moderate to severe overhydrated condition (ECW to TBW ratio ≥ 0.400). The WS value was well stratified according to the ECW to TBW ratio (normal vs. mild, p = 0.0001; mild vs. moderate to severe, p < 0.0001; normal vs. moderate to severe, p < 0.0001; overall p-value < 0.0001). In conclusion, the ECW to TBW ratio can be closely linked to WS decline in CLD patients.

show abstract

Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

Cited by 63 publications

References 87 publications

The Anthropometric Assessment With the Bioimpedance Method Is Associated With the Prognosis of Cirrhotic Patients

The Anthropometric Assessment With the Bioimpedance Method Is Associated With the Prognosis of Cirrhotic Patients

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Walking Speed: Japanese Data in Chronic Liver Diseases

Contact Info

Product

Resources

About