Sarcopenia in diabetic nephropathy: a cross-sectional study

Çeliker, Meral; Selçuk, Mustafa Yavuz; Olt, Serdar

doi:10.2478/rjim-2018-0003

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…A report from the Korean Sarcopenic Obesity Study, in which sarcopenia was defined using the skeletal muscle index only, found the prevalence of sarcopenia in patients with T2DM is much higher than the controls (15.7% vs. 6.9%) [ 12 ]. Similarly, Çeliker et al [ 28 ] reported a higher prevalence of sarcopenia in T2DM individuals (21.4%) compared with those without T2DM (15.1%) in Turkey. In our study, we reported that the prevalence of sarcopenia in older adults with T2DM was 8.9% (mean 67.6 years).…”

Section: Discussionmentioning

confidence: 85%

Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes

Sun

et al. 2021

BMC Geriatr

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Background Sarcopenia, an age-related disease, has been implicated as both a cause and consequence of type 2 diabetes mellitus (T2DM) and a symbol of poor prognosis in older adults with T2DM. Therefore, early detection and effective treatment of sarcopenia are particularly important in older adults with T2DM. We aimed to investigate the prevalence of sarcopenia in Chinese older T2DM patients and explore whether homocysteine and inflammatory indexes could serve as biomarkers and participate in the development process of sarcopenia. Methods T2DM patients aged over 60 years were consecutively recruited from the ward of department of Endocrinology, Xuanwu Hospital between April 2017 and April 2019. Sarcopenia was defined based on the standard of the Asian Working Group of Sarcopenia, including muscle mass, grip strength and gait speed. Logistic regression was used to explore the association between biochemical indicators and sarcopenia. Receiver operating characteristic (ROC) curves were applied to determine the diagnostic effect of these clinical indicators. Results Totally 582 older adults with T2DM were characterized and analyzed in the study. Approximately 8.9% of the older T2DM patients had sarcopenia. After adjusting for age, sex, body mass index (BMI) and hemoglobin A1c (HbA1c), increased concentrations of homocysteine [odds ratio (OR): 2.829; 95% confidence interval (CI), 1.064–7.525] and high-sensitive C-reactive protein (hs-CRP) (OR: 1.021; 95% CI, 1.001–1.042) were independent predictors of sarcopenia; but not interleukin-6. The combination of age, sex, BMI and HbA1c provided a discriminatory effect of sarcopenia with an area under the curve (AUC) of 0.856, when homocysteine was added to the model, the value of the ROC curve was further improved, with an AUC of 0.861. Conclusion In the current study, we demonstrated a positive correlation of homocysteine, hs-CRP with sarcopenia in older adults with T2DM and the relationship remained significant even after adjustment for HbA1c. These biomarkers (homocysteine and hs-CRP) may play important roles in the pathological process of sarcopenia.

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Section: Discussionmentioning

confidence: 85%

Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes

Sun

et al. 2021

BMC Geriatr

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“…Finally, 16 studies ( 14 – 29 ) were included in the current meta-analysis and systemic review. Among those publications, three ( 14 – 16 ) mentioned the relationship between HbA1c and sarcopenia, one ( 17 ) mentioned prediabetes, seven ( 18 – 24 ) mentioned diabetes, and five ( 25 – 29 ) mentioned diabetes-related complications, ( Figure 1 ). The characteristics of studies included were shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…A total of five studies ( 25 – 29 ) (n=3286 participants, females: 46.4%) were included. The combined OR of the relationship between diabetes complications and the risk of sarcopenia was 2.09 (95% CI:1.62–2.70, I²=0%, P=0.467).…”

Section: Resultsmentioning

confidence: 99%

The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies

et al. 2021

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AimWe performed a meta-analysis of observational studies to evaluate the association between the presence of sarcopenia and HbA1c, prediabetes, diabetes and diabetic complications.MethodThe PubMed, Embase, Cochrane and Web of Science databases were searched from inception to May 2021. We included full-text English language articles that reported the prevalence of sarcopenia in patients with and without diabetes. Quality assessment was performed according to the Newcastle- Ottawa scale for observational studies.ResultsSixteen studies were included in the meta-analysis. Three studies showed that high HbA1c levels lead to loss of muscle mass, and one study involving prediabetes showed that people with prediabetes had lower muscle mass, strength, and performance than non-diabetic population. Seven studies showed that people with diabetes had a higher risk of sarcopenia than those without diabetes (combined OR: 2.09, 95% CI:1.62-2.70). The remaining five studies suggested that diabetic complications increased the risk of sarcopenia (combined OR: 2.09,95% CI:1.62-2.70).ConclusionHigh HbA1c levels, prediabetes, diabetes and diabetes complications were associated with an increased risk of sarcopenia. Therapeutic strategies addressed to avoid the conversion of IGT to diabetes and to optimize glycemic control are warranted to prevent or arrest sarcopenia in the diabetic population

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“…Similarly, in study by Celiker et al, frequency of sarcopenia was similar in diabetes and diabetic nephropathy group. 29 In this study the BMI was low in relatively higher number of patients with diabetic nephropathy patients as compared to non-nephropathy. The causative role of either reduced visceral fat or reduced muscle mass is supported by of this finding.…”

Section: Discussionmentioning

confidence: 54%

Assessment of obesity and visceral fat in diabetic nephropathy patients

Chandra¹,

2019

Int J Adv Med

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Background: Diabetic nephropathy is one of the most common diabetic microvascular complication that typically develops after 10 years of diabetes diagnosis. The primary aim of this study was to evaluate the prevalence of obesity and visceral fat in Type 2 Diabetes (T2D) cases with nephropathy and without-nephropathy complication.Methods: In this cross-sectional study, diabetic nephropathy was diagnosed on the basis of biochemical tests of urine albumin, serum creatinine, eGFR, BP, and clinical assessment in patients with T2D. The prevalence of diabetic nephropathy estimated and the association between adiposity and diabetic nephropathy in patients T2D was evaluated. Measures of adiposity included body weight, Body Mass Index (BMI), Waist Circumference (WC), body fat percentage, muscle mass percentage and visceral fat percentage. Analysis of variance indicate difference in the various fat analysis parameters in presence and absence of nephropathy. PROC GLM procedure in the SAS Software was used for statistical calculations.Results: A total of 247 patients with type 2 diabetes (mean age 53.46±11.62 years; 39.5% females) were enrolled in this study. The participants were grouped as with Diabetic Nephropathy (DN) 41.60% (N=99) and without Diabetic Nephropathy (NDN) 58.40% (N=139). The comparison of DN and Non-DN groups showed no significant difference in the BMI, body and visceral fat, muscle mass percentage. Conclusions: Irrespective of the nephropathy status the body fat and visceral fat percentage is increased, and the muscle mass percentage is decreased in diabetes patients. As both obesity and diabetes contribute to the development and progression of renal disease, measures should to taken to reduce the body fat.

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Sarcopenia in diabetic nephropathy: a cross-sectional study

Cited by 15 publications

References 18 publications

Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes

Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes

The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies

Assessment of obesity and visceral fat in diabetic nephropathy patients

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