Sarcopenia in youth

Jung, Han Na; Jung, Chang Hee; Hwang, You‐Cheol

doi:10.1016/j.metabol.2023.155557

Cited by 47 publications

(20 citation statements)

References 98 publications

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“…(39) Moreover, sarcopenia in young patients has also been linked to gut microbiota. (40) One study found that muscle mass and gut microbiota diversity in the limbs were lower in the sedentary group than in the active group among 18-40 healthy subjects. (41) Another study in premenopausal women found positive correlations between several gut bacteria and muscle mass indicators.…”

Section: Discussionmentioning

confidence: 99%

The causal effect between gut microbiota and sarcopenia related traits: A large-scale bidirectional Mendelian randomization

Zhang

et al. 2023

Preprint

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Objective The causal relationship between gut microbiota and sarcopenia remains unclear. The objective is to investigate the causal association between gut microbiota and sarcopenia related traits, including low hand grip strength (LHGS), appendicular lean mass (ALM), and usual walking speed (UWP), using two-sample Mendelian randomization (MR). Design Two sample Mendelian randomization study. Setting and Participants Genetic instruments predicting gut microbiota were from an existing genome-wide association study (GWAS) in 18,340 individuals (85% European descent). Summary data for LHGS (254,894 individuals), ALM ((487,378 individuals), and UWP (335,288 individuals) were respectively from different GWAS. Methods We selected genetic variants as instrumental variables for 211 taxa at different taxonomic levels and performed inverse variance weighting (IVW) to estimate the causal effects. We also conducted sensitivity analyses including heterogeneity and horizontal pleiotropy. Results We identified 7, 7, and 10 genetically predicted taxa that showed causal associations with LHGS, ALM, and UWP, respectively. Of these, family Alcaligenaceae, family Family XIII, family Streptococcaceae, genus Eubacterium brachy group, and genus Terrisporobacter were found to be genetically related to LHGS, family Bacteroidaceae, genus Bacteroides, genus Oscillospira, and genus Turicibacter are genetically associated with ALM, and family Veillonellaceae, genus Flavonifractor, genus Lachnospiraceae NC2004 group, genus Ruminococcaceae UCG010, and genus Actinomyces exhibited a genetic correlation with UWP. Sensitivity analysis shows that the above results do not violate the MR assumptions. Conclusion Our study provides novel evidence for the causal role of gut microbiota in sarcopenia. Modulating the gut microbiota may have potential implications for the prevention and treatment of sarcopenia.

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Section: Discussionmentioning

confidence: 99%

The causal effect between gut microbiota and sarcopenia related traits: A large-scale bidirectional Mendelian randomization

Zhang

et al. 2023

Preprint

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“…The prevalence of sarcopenia is expected to increase due to global population aging, with projections indicating that over 500 million individuals will be affected by this condition by the year 2050 7 . Furthermore, a recent study also discovered that it can occur at a young age as a result of a variety of chronic illnesses such as anorexia, cancer, and malnutrition 8 . As a progressive geriatric syndrome, sarcopenia leads to various negative health outcomes, including falls, disability, fractures, and premature mortality 9 .…”

Section: Introductionmentioning

confidence: 99%

Exploring the causal link between circulating cytokines and sarcopenia traits: A Mendelian randomization analysis

Di,

Luyao,

Chengwei

et al. 2024

Environmental Toxicology

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BackgroundPrevious observational studies have linked circulating cytokines to sarcopenia, but their causal relationship remains unclear. This study employed Mendelian Randomization (MR) to investigate the causal links between circulating cytokines and sarcopenia‐related traits using genetic data.MethodsA two‐sample bidirectional MR analysis was conducted using data from individuals of European ancestry, utilizing genome‐wide association studies (GWAS) statistics. The study selected instrumental single nucleotide polymorphisms (SNPs) significantly associated with circulating cytokines and applied multiple MR methods, including inverse variance weighted (IVW), Weighted Median, MR‐Egger, Weighted Mode, Simple Mode, and MR‐PRESSO. The traits analyzed were appendicular lean mass (ALM) and grip strength. Heterogeneity, robustness, and consistency of results were assessed using Cochran's Q statistic, MR‐Egger regression, and “leave‐one‐out” sensitivity analyses.ResultsThe IVM‐MR analysis showed a casual association between genetically predicted circulating levels of interleukin‐16 and both ALM and grip strength (ALM: OR = 0.990, 95% CI: 0.980–1.000, p = .049; grip strength: OR = 0.971, 95% CI: 0.948–0.995, p = .020). Additionally, interferon‐gamma‐induced protein 10 (IP‐10), interleukin‐1‐beta (IL‐1β), and hepatocyte growth factor (HGF) were correlated with ALM and vascular endothelial growth factor (VEGF), interleukin‐12 (IL‐12), and interleukin‐5 (IL‐5) with grip strength. Comparable results were confirmed via the MR‐Egger, Weighted Median, Weighted Mode, and Simple Mode methods. Sensitivity analysis showed no horizontal pleiotropy to bias the causal estimates.ConclusionThe results suggest a significant causal effect of inflammatory cytokines on sarcopenia, offering new avenues for therapeutic target development. However, the study's focus on a European ancestry cohort limits its generalizability to other populations. Future research should aim to include diverse ethnic groups to validate and broaden these findings, thereby enhancing our understanding of sarcopenia's mechanisms in a global context.

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“…The risk of developing sarcopenia in early adulthood, resulting in exaggerated muscle dysfunction in later life, is still in the early stages of exploration despite its clinical significance [ 13 ]. While the prevalence of sarcopenia among young individuals is comparatively lower than in older adults, the extended duration of sarcopenia during youth may lead to more significant long-term health issues [ 13 ]. Consequently, it is crucial to identify and treat sarcopenia early in young individuals for primary prevention and to limit its progression [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…While the prevalence of sarcopenia among young individuals is comparatively lower than in older adults, the extended duration of sarcopenia during youth may lead to more significant long-term health issues [ 13 ]. Consequently, it is crucial to identify and treat sarcopenia early in young individuals for primary prevention and to limit its progression [ 13 ]. Estimating the global sarcopenia prevalence in early adulthood is challenging, given the limited epidemiological research on this condition [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Are accelerometer-measured sitting and physical activity times associated with muscle mass and strength in healthy young adults in the UAE?

Qadah,

Al-Sharman,

Shalash

et al. 2024

Heliyon

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Sarcopenia in youth

Cited by 47 publications

References 98 publications

The causal effect between gut microbiota and sarcopenia related traits: A large-scale bidirectional Mendelian randomization

The causal effect between gut microbiota and sarcopenia related traits: A large-scale bidirectional Mendelian randomization

Exploring the causal link between circulating cytokines and sarcopenia traits: A Mendelian randomization analysis

Are accelerometer-measured sitting and physical activity times associated with muscle mass and strength in healthy young adults in the UAE?

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