Sarcopenia is an Independent Prognostic Factor in Patients With Pancreatic Cancer – a Meta-analysis

Thormann, Maximilian; Hinnerichs, Mattes; Ordonez, Felix Barajas; Perrakis, Aristotelis; Croner, Roland S.; Omari, Jazan; Pech, Maciej; Zamsheva, Marina; Meyer, Hans‐Jonas; Wienke, Andreas; Surov, Alexey

doi:10.1016/j.acra.2022.10.025

Cited by 17 publications

(4 citation statements)

References 74 publications

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“…Thormann et al concluded that sarcopenia was strongly relevant to dismal prognosis in both radical and palliative settings. Unfortunately, they did not conduct further subgroup analyses to explore the sources of heterogeneity [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis

Liu,

An,

Zhang

et al. 2024

World J Surg Onc

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Background Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery. Methods Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software. Results A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P < 0.00001) and PFS (HR = 1.55, P < 0.00001). However, this association was not obvious in regard to the incidence of major complications (OR = 1.33, P = 0.11). Conclusion Preoperative sarcopenia was preliminarily proved to be associated with the terrible prognosis of pancreatic cancer after surgery. However, this relationship needs to be further validated in more prospective studies.

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Section: Discussionmentioning

confidence: 99%

Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis

Liu,

An,

Zhang

et al. 2024

World J Surg Onc

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“…21 b) Sarcopenia: it is an independent risk factor for pre-and postoperative complications, the prevalence ranges between 30% and 65%. 22 It is associated with toxicity induced by CT. 6,23 c) A systematic review by Ratnayake et al 24 and recently, a meta-analysis carried out by Thormann et al 23 concluded that sarcopenia was not correlated with postoperative complications, but was associated with longer hospital stay (LOS).…”

Section: Syndromes Related To Mnmentioning

confidence: 99%

Update nutritional management in patients with pancreatic ductal adenocarcinoma: A literature reviews

Suarez,

Marturano,

Canicoba

et al. 2024

GHOA

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Only 20 % of patients are operable at the time of diagnosis. However, the survival rate varies among patients depending on immune response and nutritional status. Weight loss (WL) is frequent and multifactorial, so anorexia-cachexia syndrome and exocrine pancreatic insufficiency (EPI) should be considered. The nutritional care process must be carried out in all cases from the moment of suspected diagnosis and during the disease. The management of patients with PDAC must be personalized, individualizing behaviors, and from a multidisciplinary perspective at each stage of the disease. The objective of the present review is to offer a tool that facilitates the identification of individuals at nutritional risk and to describe the most appropriate nutritional strategies to improve the quality of care for patients with PDAC.

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“…Sarcopenia is commonly described as a progressive and generalized disorder of skeletal muscle, re ecting a decline in the patient's physical functioning [2]. In certain chronic diseases and tumors, such as colorectal cancer [3], breast cancer [4], pancreatic cancer [5], hepatocellular carcinoma [6], and cardiovascular disease (CVD) [7], the adverse prognostic effects of sarcopenia have been evaluated. The effect of sarcopenia on the survival of lung cancer patients has also been proven [8].…”

Section: Introductionmentioning

confidence: 99%

Preoperative pectoralis muscle index predicts recurrence and metastasis in early-stage non- small cell lung cancer patients

Shi,

Wu,

Jiang

et al. 2024

Preprint

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Background Sarcopenia is a well-established prognostic factor in patients with malignancies, with the muscle index serving as a key parameter in evaluating sarcopenia. However, the relationship between the pectoralis muscle index (PMI) determined by preoperative computed tomography (CT) and recurrence-free survival (RFS), as well as distant metastasis-free survival (DMFS), remains unclear in patients with early-stage non-small cell lung cancer (NSCLC). Methods Consecutive patients who underwent curative-intent resection for stage I to IIIA NSCLC between 2013 and 2018 at a cancer center were retrospectively identified. The Cox proportional hazard model was employed to analyze the correlation between PMI and survival, with subgroup analyses conducted to explore potential heterogeneity among different subgroups. Finally, the relative influence of each parameter was compared using a gradient boosting model (GBM). Results A total of 2110 patients (median (IQR) age 59.00 (52.00, 66.00) years, 1125 (53.32%) males, median follow-up of 64.73 months) were evaluated. Kaplan-Meier survival analysis showed that the RFS rate, DMFS rate, lung metastasis-free survival (MFS) rate, liver MFS rate, brain MFS rate, bone MFS rate, and adrenal MFS rate of patients in the high PMI group were higher than those in the low PMI group, all with P < 0.001. In the multivariable analysis, low PMI is still associated with shorter RFS ( hazard ratio [HR] = 1.34, 95% confidence interval [CI]: (1.10, 1.62), P = 0.004), DMFS (HR = 1.35, 95% CI: (1.11, 1.65), P = 0.003), lung MFS (HR = 1.47, 95% CI (1.19, 1.81), P < 0.001) and bone MFS (HR = 1.38, 95% CI: (1.11, 1.73), P = 0.004). These associations were consistent in subgroup analysis of different gender, age, tumor stage, histologic type, and surgical approach group. Conclusions As an independent predictor of RFS and DMFS in patients with early-stage NSCLC, preoperative CT-based PMI may contribute to further refining the risk stratification of NSCLC.

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Sarcopenia is an Independent Prognostic Factor in Patients With Pancreatic Cancer – a Meta-analysis

Cited by 17 publications

References 74 publications

Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis

Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis

Update nutritional management in patients with pancreatic ductal adenocarcinoma: A literature reviews

Preoperative pectoralis muscle index predicts recurrence and metastasis in early-stage non- small cell lung cancer patients

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