Sarcopenia is associated to an impaired autonomic heart rate modulation in community-dwelling old adults

Freitas, Verônica Porto de; Passos, Rafael da Silva; Oliveira, Alinne Alves; Ribeiro, Ícaro José Santos; Freire, Ivna Vidal; Schettino, Ludmila; Teles, Mauro Fernandes; Casotti, Cézar Augusto; Pereira, Rafael

doi:10.1016/j.archger.2018.01.006

Cited by 29 publications

(25 citation statements)

References 33 publications

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“…Moreover, it was demonstrated that sarcopenia could worsen the functioning of the autonomic nervous system. 24 Taken together with our results, the pathophysiological conditions causing sarcopenia might affect the functions of detrusor smooth muscle or autonomic nervous system innervating the bladder, leading to impaired detrusor contractility. This study had a few limitations.…”

Section: Discussionsupporting

confidence: 83%

“…Recently, it has been reported that similar pathophysiological mechanisms contribute to cardiac dysfunction, including mitochondrial dysfunction, inflammation, and malnutrition, which implies that these factors could influence smooth muscle function as well as skeletal muscle function. Moreover, it was demonstrated that sarcopenia could worsen the functioning of the autonomic nervous system . Taken together with our results, the pathophysiological conditions causing sarcopenia might affect the functions of detrusor smooth muscle or autonomic nervous system innervating the bladder, leading to impaired detrusor contractility.…”

Section: Discussionsupporting

confidence: 80%

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Investigation of the relationship between bladder function and sarcopenia using pressure flow studies in elderly male patients

Majima

Funahashi

Matsukawa

et al. 2019

Neurourology and Urodynamics

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Aims Although detrusor underactivity is often encountered in elderly patients, the etiology remains unclear. We have hypothesized that sarcopenia was associated with impaired bladder contractility. Therefore, we have evaluated the relationship between bladder contractility and clinical parameters including sarcopenia markers in elderly male patients. Methods This retrospective, single‐centre study included male patients over 65 years of age who underwent a pressure flow study (PFS). We excluded patients with any previous medical histories that could affect bladder function, currently on urinary medication, and with no available data of abdominal CT scan. The psoas muscle area (PMA) (cm2/m2) was measured as a surrogate for psoas muscle mass on computed tomography. PMA, serum CRP, and albumin are known as sarcopenia markers. Correlation and multiple regression analyses were performed to evaluate the association of bladder contractility index (BCI) with the following parameters: age, body mass index (BMI), prostate volume, bladder outlet obstruction index (BOOI), serum C‐reactive protein (CRP), serum albumin, and PMA. Results Out of 558 male patients identified in our PFS database, 119 patients were enrolled. In the correlation analysis, age, prostate volume, serum albumin, BOOI, and PMA significantly correlated with BCI. However, no significant correlation of BCI with CRP or BMI was observed. Multiple linear regression analysis showed that serum albumin, BOOI, and PMA were significantly associated with BCI. Conclusions We have demonstrated that serum albumin and PMA were significantly positively associated with detrusor contractility. It is possible that sarcopenia is associated with impaired detrusor contractility.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 80%

Investigation of the relationship between bladder function and sarcopenia using pressure flow studies in elderly male patients

Majima

Funahashi

Matsukawa

et al. 2019

Neurourology and Urodynamics

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“…Comparably, older adults (mean age 75.7 ± 0.2 years) who followed a long-term sportive lifestyle exhibited increased 5-min global HRV (SDNN) and parasympathetic HRV indices (e.g., RMSSD and HF power) compared to their active but non-sportive counterparts; Buchheit et al, 2004 ). Moreover, older adults affected by sarcopenia showed reduced modulation of the parasympathetic autonomic nervous system as assessed with 5-min time-domain and nonlinear HRV indices (Freitas et al, 2018 ). Similarly, a shift toward sympathetic predominance was evident in frail elderly women, suggesting that HRV monitoring may be of value for the prevention, diagnosis, and treatment of the frailty syndrome (Katayama et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…As such, HRV measures may reflect the adaptivity of the brain–body system (Ernst, 2017 ). Furthermore, HRV indices are associated with numerous domains of cognitive and physical functioning in older adults (Albinet et al, 2010 ; Ogliari et al, 2015 ; Freitas et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Variability Mainly Relates to Cognitive Executive Functions and Improves Through Exergame Training in Older Adults: A Secondary Analysis of a 6-Month Randomized Controlled Trial

Eggenberger

Annaheim

Kündig

et al. 2020

Front. Aging Neurosci.

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Heart rate variability (HRV) mirrors autonomic nervous system activities and might serve as a parameter to monitor health status in older adults. However, it is currently unknown which functional health measures, including cognitive, physical, and gait performance parameters, are most strongly related to HRV indices. This knowledge would enable implementing HRV assessments into health monitoring routines and training planning for older adults. Simultaneous cognitive–motor and exergame training may be effective to improve HRV indices but has not been investigated yet. Eighty-nine healthy older adults (≥70 years of age) were randomized into three groups: (1) virtual reality video game dancing, i.e., exergaming (DANCE); (2) treadmill walking with simultaneous verbal memory training (MEMORY); or (3) treadmill walking only (PHYS). Strength and balance exercises complemented each program. Over 6 months, two weekly 1-h training sessions were performed. HRV indices (standard deviation of N–N intervals, SDNN; root mean square of successive R–R interval differences, RMSSD; and absolute power of high-frequency band (0.15–0.4 Hz), HF power) and various measures of cognitive, physical, and gait performance were assessed at baseline and after 3 months and 6 months. Multiple linear regression analyses with planned comparisons were calculated. At baseline, 8–12% of HRV variance was significantly explained by cognitive executive functions and leg strength (inversely related). Verbal long-term memory, aerobic and functional fitness, and gait performance did not contribute to the model (SDNN: R 2 = 0.082, p = 0.016; RMSSD: R 2 = 0.121, p = 0.013; HF power: R 2 = 0.119, p = 0.015). After 6 months, DANCE improved HRV indices, while MEMORY and PHYS did not (time × intervention interactions: first-contrast DANCE/MEMORY vs. PHYS: SDNN p = 0.014 one-tailed, Δ R 2 = 0.020 and RMSSD p = 0.052 one-tailed (trend), Δ R 2 = 0.007; second-contrast DANCE vs. MEMORY: SDNN p = 0.002 one-tailed, Δ R 2 = 0.035, RMSSD p = 0.017 one-tailed, Δ R 2 = 0.012, and HF power p = 0.011 one-tailed, Δ R 2 = 0.013). We conclude that mainly cognitive executive functions are associated with HRV indices and that exergame training improves global and parasympathetic autonomic nervous system activities in older adults. Periodic assessments of HRV in older citizens could be particularly beneficial to monitor cognitive health and provide indications for preventative exercise measures.

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“…The exacerbation of the renin–angiotensin–aldosterone system acts on the hypothalamic paraventricular nucleus, causing excitation of the sympathetic tone [ 49 ]. On the other hand, the reduction in muscle mass also reduces the expression of myokines, including irisin, involved in the maintenance of vagal tone and in the parasympathetic modulation of cardiac function [ 50 , 51 ].…”

Section: Pathophysiology Of the Association Of Sarcopenic Obesity Cardiovascular Disease And Cancermentioning

confidence: 99%

The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications

Silveira

Filho

Spexoto

et al. 2021

IJMS

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Obesity is globally a serious public health concern and is associated with a high risk of cardiovascular disease (CVD) and various types of cancers. It is important to evaluate various types of obesity, such as visceral and sarcopenic obesity. The evidence on the associated risk of CVD, cancer and sarcopenic obesity, including pathophysiological aspects, occurrence, clinical implications and survival, needs further investigation. Sarcopenic obesity is a relatively new term. It is a clinical condition that primarily affects older adults. There are several endocrine-hormonal, metabolic and lifestyle aspects involved in the occurrence of sarcopenic obesity that affect pathophysiological aspects that, in turn, contribute to CVD and neoplasms. However, there is no available evidence on the role of sarcopenic obesity in the occurrence of CVD and cancer and its pathophysiological interplay. Therefore, this review aims to describe the pathophysiological aspects and the clinical and epidemiological evidence on the role of sarcopenic obesity related to the occurrence and mortality risk of various types of cancer and cardiovascular disease. This literature review highlights the need for further research on sarcopenic obesity to demonstrate the interrelation of these various associations.

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Sarcopenia is associated to an impaired autonomic heart rate modulation in community-dwelling old adults

Cited by 29 publications

References 33 publications

Investigation of the relationship between bladder function and sarcopenia using pressure flow studies in elderly male patients

Investigation of the relationship between bladder function and sarcopenia using pressure flow studies in elderly male patients

Heart Rate Variability Mainly Relates to Cognitive Executive Functions and Improves Through Exergame Training in Older Adults: A Secondary Analysis of a 6-Month Randomized Controlled Trial

The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications

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