Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis

Peng, Peter D.; Vledder, Mark G. van; Tsai, Susan; Jong, Mechteld C. de; Makary, Martin; Ng, Julie; Edil, Barish H.; Wolfgang, Christopher L.; Schulick, Richard D.; Choti, Michael A.; Kamel, Ihab R.; Pawlik, Timothy M.

doi:10.1111/j.1477-2574.2011.00301.x

Cited by 375 publications

(413 citation statements)

References 44 publications

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“…Further studies are necessary to clarify how sarcopenia increases the risk of infectious complications after gastric cancer surgery. In the present study, the LBM as measured by BIA was not a significant risk factor for surgical morbidity, which was contradictory to the previous studies evaluating the slices examined by computed tomography (CT) [11,12]. This discrepancy could be explained by the difference in the characteristics of the cohort and the methodological difference.…”

Section: Discussioncontrasting

confidence: 99%

“…HGS would have a great advantage to select patients with good performance status but high risk for morbidity. Previous studies for other upper abdominal surgery such as hepatocellular carcinoma, pancreas cancer, and metastatic liver tumor demonstrated that sarcopenia was a risk factor for postoperative complication [12,35,36]. However, no report showed a correlation of sarcopenia and respiratory complications, which is different from the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…& Takaki Yoshikawa yoshikawat@kcch.jp following colorectal cancer surgery and metastatic liver resection [11,12]. However, muscle mass does not correlate linearly with muscle strength.…”

Section: Introductionmentioning

confidence: 99%

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Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

et al. 2015

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Background Sarcopenia is a decrease in both muscle mass and strength. It remains unclear whether sarcopenia is associated with morbidity after gastric cancer surgery. This study evaluated the impact of sarcopenia on the morbidity of gastric cancer surgery. Methods A total of 293 gastric cancer patients who underwent curative surgery between May 2011 and June 2013 were retrospectively examined. Patients with performance status 3 or 4 were excluded. Preoperative lean body mass (LBM) was evaluated by bioelectrical impedance analysis and expressed as LBM index. Preoperative muscle function was measured by hand grip strength (HGS). The cutoff values were the gender-specific lowest 20 %. Grade 2 or higher morbidities, as retrospectively evaluated by the Clavien-Dindo classification, were obtained from the patient record. The risk factors for morbidity were examined by univariate and multivariate analyses. Results Morbidity was observed in 39 patients (13.3 %), including 7 with pancreatic leakage, 12 with anastomotic leakage, and 4 with intraabdominal abscesses, but no mortality was observed. The univariate analysis showed that male gender, total gastrectomy, splenectomy, and a low HGS were significant risk factors for morbidity. A low LBM was not a significant risk factor. A low HGS, male gender, and total gastrectomy remained significant in the multivariate analysis. Conclusions A low hand grip strength was a significant risk factor for morbidity after gastric cancer surgery. The importance of the hand grip strength as a risk factor should be examined in future prospective studies.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

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Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

et al. 2015

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“…Although in some studies a correlation between PA and post‐operative complications was seen, the majority have failed to prove a relationship between PA‐assessed sarcopenia and survival 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23. Only few have actually assessed the agreement between PA and SMA within their population; Jones et al studied 100 patients with colorectal cancer and reported a Spearman correlation of 0.8 for PA and SMA and a Spearman correlation of 0.94 for PA and PLW, which could not be reproduced in our cohort 11.…”

Section: Discussionmentioning

confidence: 99%

“…This method has been used to predict surgical complications in different cancer types with contrasting results. PA has shown a correlation with post‐operative complications in individual studies on colorectal cancer, colorectal liver metastases, kidney cancer, bladder cancer, cholangiocarcinoma, and hepatocellular cancer,11, 12, 13, 14, 15, 16 while this effect was not seen in other pancreatic cancer, endometrial cancer, biliary cancer, or sarcoma studies 17, 18, 19, 20. Interestingly, only few cancer studies were able to show a correlation between PA and survival 21, 22, 23.…”

Section: Introductionmentioning

confidence: 99%

Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer

Rutten

Ubachs

Kruitwagen

et al. 2017

J cachexia sarcopenia muscle

163

133

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BackgroundComputed tomography measurements of total skeletal muscle area can detect changes and predict overall survival (OS) in patients with advanced ovarian cancer. This study investigates whether assessment of psoas muscle area reflects total muscle area and can be used to assess sarcopenia in ovarian cancer patients.MethodsOvarian cancer patients (n = 150) treated with induction chemotherapy and interval debulking were enrolled retrospectively in this longitudinal study. Muscle was measured cross sectionally with computed tomography in three ways: (i) software quantification of total skeletal muscle area (SMA); (ii) software quantification of psoas muscle area (PA); and (iii) manual measurement of length and width of the psoas muscle to derive the psoas surface area (PLW). Pearson correlation between the different methods was studied. Patients were divided into two groups based on the extent of change in muscle area, and agreement was measured with kappa coefficients. Cox‐regression was used to test predictors for OS.ResultsCorrelation between SMA and both psoas muscle area measurements was poor (r = 0.52 and 0.39 for PA and PLW, respectively). After categorizing patients into muscle loss or gain, kappa agreement was also poor for all comparisons (all κ < 0.40). In regression analysis, SMA loss was predictive of poor OS (hazard ratio 1.698 (95%CI 1.038–2.778), P = 0.035). No relationship with OS was seen for PA or PLW loss.ConclusionsChange in psoas muscle area is not representative of total muscle area change and should not be used to substitute total skeletal muscle to predict survival in patients with ovarian cancer.

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Morphometric Age and Mortality After Liver Transplant

et al. 2014

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Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis

Abstract: Sarcopenia impacts short-, but not long-term outcomes after resection of CRLM. While patients with sarcopenia are at an increased risk of post-operative morbidity and longer hospital stay, long-term survival is not impacted by the presence of sarcopenia.

Cited by 375 publications

References 44 publications

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer

Morphometric Age and Mortality After Liver Transplant

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