Sarcopenia, nutritional status and type 2 diabetes mellitus: A cross‐sectional study in a group of Mexican women residing in a nursing home

Velázquez-Alva, María Consuelo; Irigoyen-Camacho, María Esther; Zepeda-Zepeda, Marco Antonio; Lazarevich, Irina; Arrieta‐Cruz, Isabel; D'Hyver, Carlos

doi:10.1111/1747-0080.12551

Cited by 38 publications

(45 citation statements)

References 28 publications

(36 reference statements)

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“…However, poor nutritional status is not only associated with depression or polypharmacy in older people. Previously published studies showed a strong association between physical dependency and poor nutritional status in Mexican nursing home residents [4]. In a cross-sectional study in community-dwelling older Chinese adults, it was found that complete physical functional dependence was strongly associated with malnutrition [39].…”

Section: Discussionmentioning

confidence: 93%

“…A recent meta-analysis study including cross-sectional, prospective, retrospective, and case-control studies showed that the prevalence of malnutrition is quite different in older adults living in the community (4.0%) compared to those who are hospitalized (22.3%), those who are living in nursing homes (15.2%), or those in long-term care institutions (30.0%) [ 3 ]. In this regard, very little information is available about the malnutrition prevalence in older Mexican persons, either community-dwelling or living in nursing homes [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

et al. 2020

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This study evaluated the association between nutritional status, depressive symptoms, and the number of prescription drugs taken by older adults living in nursing homes in Mexico City. In a cross-sectional study, 262 participants were subjected to anthropometric and nutritional (Mini Nutritional Assessment (MNA)) evaluations; additionally, their depression (Geriatric Depression Scale (GDS)) and functional status were assessed. Multiple logistic regression was used for identifying factors associated with the risk of malnutrition/malnourishment. The mean age of participants was 83.1 ± 8.6 years. A total of 59.9% and 21.1% were at risk of malnutrition and malnourished, respectively. With respect to depression, 27.9% of the participants had mild depression, while 11.4% showed severe depression. An inverse correlation between MNA evaluations and depression scores was found (Spearman’s ρ = −0.4624, p < 0.001); residents with a better nutritional status had lower depression scores. Individuals with depressive symptoms were approximately five times more likely to be at risk of malnutrition or malnourished (OR = 5.82, 95% CI = 2.27–14.89) than individuals without depression. Residents taking three or more prescription drugs daily (OR = 1.83, 95% CI = 1.27–2.63, p < 0.001) were more likely to be at risk of malnutrition or malnourished. In summary, poor nutritional status was associated with depression, while the intake of numerous prescription drugs was associated with being at risk of malnutrition or malnourished.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

et al. 2020

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“…The risk factors related to sarcopenia in elderly people with T2DM are age, diabetes duration, gender, presence of comorbidity, microvascular complications [32,99], reduced hip circumference, lower BMI, low physical activities [100], and poor nutritional status [101,102].…”

Section: Type 2 Diabetes Mellitus and Sarcopeniamentioning

confidence: 99%

The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms

Massimino

Izzo

Riccardi

et al. 2021

Cells

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The age-related decrease in skeletal muscle mass together with the loss of muscle power and function is defined sarcopenia. Mounting evidence suggests that the prevalence of sarcopenia is higher in patients with type 2 diabetes mellitus (T2DM), and different mechanisms may be responsible for this association such as impaired insulin sensitivity, chronic hyperglycemia, advanced glycosylation end products, subclinical inflammation, microvascular and macrovascular complications. Glucose-lowering drugs prescribed for patients with T2DM might impact on these mechanisms leading to harmful or beneficial effect on skeletal muscle. Importantly, beyond their glucose-lowering effects, glucose-lowering drugs may affect per se the equilibrium between protein anabolism and catabolism through several mechanisms involved in skeletal muscle physiology, contributing to sarcopenia. The aim of this narrative review is to provide an update on the effects of glucose-lowering drugs on sarcopenia in individuals with T2DM, focusing on the parameters used to define sarcopenia: muscle strength (evaluated by handgrip strength), muscle quantity/quality (evaluated by appendicular lean mass or skeletal muscle mass and their indexes), and physical performance (evaluated by gait speed or short physical performance battery). Furthermore, we also describe the plausible mechanisms by which glucose-lowering drugs may impact on sarcopenia.

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“…A large portion of vitamin D requirements is obtained through sunlight exposure in young people; but the supply of this vitamin is reduced in the old age due to an inadequate nutrition and the presence of chronic diseases [24,25]. A poor nutritional status is a frequent health problem found in older adults, and in some populations, it has been found in association with sarcopenia and dynapenia [26][27][28]. Furthermore, it is well known that an inadequate diet is a determinant factor in vitamin D deficiency [29].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, a dramatic worldwide increase in the prevalence of T2DM has been observed in association with skeletal muscle disorders in older adults [41,42]. In this regard, epidemiological studies have shown a high prevalence of sarcopenia in older adults presenting poor nutritional status and T2DM [27,43,44].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency is Associated with Handgrip Strength, Nutritional Status and T2DM in Community-Dwelling Older Mexican Women: A Cross-Sectional Study

Mendoza-Garcés¹,

Velázquez-Alva

Cabrer-Rosales

et al. 2021

Nutrients

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The aim of this study was to evaluate the association between handgrip strength, nutritional status and vitamin D deficiency in Mexican community-dwelling older women. A cross sectional study in women ≥ 60 years-old was performed. Plasma 25-hydroxyvitamin D (25(OH)D) concentrations were measured by a quantitative immunoassay technique. Handgrip strength was assessed using a dynamometer, while nutritional status was assessed through the Full Mini Nutritional Assessment (Full-MNA). A total of 116 women participated in the study, their mean age was 70.3 ± 5.8 years; 49.1% of the study group had plasma 25(OH)D levels lower than 40 nmol/L [16 ng/mL]. Meanwhile, 28.45% of participants had low handgrip strength (<16 kg), and 23.1% were identified at risk of malnutrition/malnourished according with Full-MNA score. Women with 25(OH)D deficiency (<40 nmol/L [16 ng/mL]) were more likely to have low handgrip strength (OR = 2.64, p = 0.025) compared with those with higher 25(OH)D values. Additionally, being malnourished or at risk of malnutrition (OR = 2.53, p = 0.045) or having type 2 diabetes mellitus (T2DM) (OR = 2.92, p = 0.044) was also associated with low 25(OH)D. The prevalence of low plasma 25(OH)D concentrations was high among Mexican active older women. Low handgrip strength, being at risk of malnutrition/malnourished, or diagnosed with T2DM was also associated with Vitamin D deficiency.

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Sarcopenia, nutritional status and type 2 diabetes mellitus: A cross‐sectional study in a group of Mexican women residing in a nursing home

Cited by 38 publications

References 28 publications

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

Prevalence of Malnutrition and Depression in Older Adults Living in Nursing Homes in Mexico City

The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms

Vitamin D Deficiency is Associated with Handgrip Strength, Nutritional Status and T2DM in Community-Dwelling Older Mexican Women: A Cross-Sectional Study

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