Sarcopenia, Osteoporosis and Fractures

Cederholm, Tommy

doi:10.1002/9781118338032.ch12

Cited by 1 publication

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, sarcopenia implies a decrease in the number of type II (fast) muscle fibers and motoneurons with significant effects on muscle mass and strength, on balance, and on enhancing the risk of falls [33]. Secondly, sarcopenia is involved in the genesis of hip fracture because it is closely linked with the loss of bone mass and strength.…”

Section: Discussionmentioning

confidence: 99%

The role of sarcopenia in the risk of osteoporotic hip fracture

2015

View full text Add to dashboard Cite

Several common age-related mechanisms and factors influence muscle and bone, affecting functionality of both tissues. Sarcopenia is closely linked with osteoporosis, and their combined effect may exacerbate negative health outcomes. Fall-related fractures are some of the most serious consequences of these two systemic pathologies, with hip fracture being a major complication affecting osteoporotic and sarcopenic elderly. This work aims to review the literature on the current state of knowledge about the relations between sarcopenia and osteoporosis and to present the association between sarcopenia and osteoporosis and the risk of hip fracture. A literature search was performed in PubMed and Scopus databases for articles with the predefined terms "sarcopenia," "muscular atrophy," "femoral fractures," "hip fractures," "osteoporosis," and "bone density." There is a growing and significant interest being directed to sarcopenia and associated risk for osteoporotic hip fracture, but there still is a notorious heterogeneity in the methodology and cohort size of the available studies. Collectively, most of the studies herein analyzed indicate that sarcopenia could be a predictor of risk for hip fracture. The simultaneous evaluation of sarcopenia and osteoporosis may be of importance in identifying those patients in higher risk of suffering an osteoporotic hip fracture and who could benefit from preventive or therapeutic interventions, or both.

show abstract

Section: Discussionmentioning

confidence: 99%