Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Xue, Qiqi; Wu, Jie; Ren, Yan; Hu, Junjie; Yang, Ke; Cao, Jianjun

doi:10.1186/s12877-021-02438-w

Cited by 37 publications

(26 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sarcopenia, defined as an age-related generalized loss of skeletal muscle mass, has been related to frailty, overall functional impairment, and poor survival in geriatric population [ 8 – 10 ]. Although the universal measurements for sarcopenia remain to be established [ 11 ], sarcopenia has been proposed as a predictor of poor prognosis in patients of various chronic diseases, such as cancer [ 12 ], coronary artery disease [ 13 ], and chronic kidney disease [ 14 ]. Interestingly, patients with sepsis are also vulnerable to muscle catabolism, muscle weakness, and progressive muscle loss with the progression of the disease [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Liu

Zhao

2022

International Journal of Clinical Practice

View full text Add to dashboard Cite

Background. The association between sarcopenia at admission and mortality in patients with sepsis has not been comprehensively evaluated. We performed a meta-analysis to systematically evaluate the above association. Methods. This meta-analysis included relevant observational studies from Medline, Embase, and Web of Science databases. A random-effect model after incorporation of the intrastudy heterogeneity was selected to pool the results. Subgroup analyses were applied to evaluate the influences of study characteristics on relationship. Results. Ten cohort studies including 2396 patients with sepsis were included, and 1496 (62.4%) of them had sarcopenia at presentation. Pooled results showed that compared to those without sarcopenia, septic patients with sarcopenia had a significantly increased early (in-hospital or 1-month) mortality risk (risk ration (RR): 2.14, 95% confidence interval (CI): 1.60–2.87, P < 0.001; I2 = 46%). Subgroup analyses showed consistent association between sarcopenia and increased acute mortality risk in septic patients which were not affected by study characteristics such as study design, country of the study, clinical settings, diagnostic criteria for sepsis, age, gender of the patients, and methods for diagnosis of sarcopenia ( P for all subgroup analyses >0.05). Further meta-analyses showed that sarcopenia was also associated with increased mortality risk in septic patients at 3–6 months (RR: 2.13, 95% CI: 1.58–2.89, P < 0.001; I2 = 0%) and at 1 year (RR: 1.57, 95% CI: 1.09–2.24, P = 0.01; I2 = 29%). Conclusions. Current evidence suggests that sarcopenia may be a predictor of mortality in patients with sepsis.

show abstract

Section: Introductionmentioning

confidence: 99%

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Liu

Zhao

2022

International Journal of Clinical Practice

View full text Add to dashboard Cite

show abstract

“…In conclusion, based on this observation, the self-reported difficulty in walking 400 m could be suggested as a method for the early detection of individuals at risk of probable sarcopenia. Simplifying the screening process using a single question could help to earlier identify sarcopenia and consequently to be more proactive in implementing prevention and treatment strategies [ 29 , 30 ]. Furthermore, in the near future the use of technological systems (i.e., smartphones, social media) could help to reach a greater segment of the population and enhance the usefulness of this tool.…”

Section: Discussionmentioning

confidence: 99%

Self-reported difficulty in walking 400 meters: the “red flag” for probable sarcopenia

et al. 2022

View full text Add to dashboard Cite

Background Sarcopenia is associated with adverse outcomes in older people. Several tools are recommended to assess muscle mass, muscle strength and physical performance, but are not always available in daily practice. Objective The aim of the present study is to evaluate if there is a correlation between the personal perception of physical performance (assessed through a question on personal functional status) and the effective presence of sarcopenia (according to the EWGSOP2 definition) using data from the Longevity Check-up 7 + project. Design Cross-sectional study. Setting The Longevity Check-up 7 + project is an ongoing study started in June 2015 and conducted in unconventional settings (i.e., exhibitions, malls, and health promotion campaigns). Subjects Candidate participants are eligible for enrollment if they are at least 18 years of age and provide written informed consent. For the present study subjects 65 years age old and older have been considered (n = 2901). Methods According to the most recent EWGSOP2 consensus definition, subjects were defined to be affected by probable sarcopenia when handgrip strength was less than 27 kg in male and less than 16 kg in female, respectively. Furthermore, a single question assessed the perceived health status regarding own physical performance: “Do you have any difficulty in walking 400 m?”. Results Using the EWGSOP2 algorithm, 529 (18,9%) participants were identified as affected by probable sarcopenia with a significant higher prevalence among subjects with self-reported difficulty in walking 400 m compared to participant without any difficulty (33.6% versus 13.1%, respectively; p < 0.001). Relative to participants without self-reported difficulty, those subjects with self-reported difficulty in walking 400 m showed a significantly higher risk of sarcopenia (odds ratio [OR]: 3.34; 95% confidence interval [CI]: 2.75–4.07). Conclusions A single “Red Flag” question such as “Do you have any difficulty in walking 400 m?” should be considered as a recommended method for screening probable sarcopenia risk.

show abstract

“…In conclusion, based on this observation, the self-reported di culty in walking 400 meters could be suggested as a method for the early detection of individuals at risk of probable sarcopenia. Simplifying the screening process using a single question could help to earlier identify sarcopenia and consequently to be more proactive in implementing prevention and treatment strategies [29]; [30].…”

Section: Discussionmentioning

confidence: 99%

Self-reported Difficulty in Walking 400 Meters: the “red Flag” for Probable Sarcopenia

Salini

Russo

Calvani

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Sarcopenia is associated with adverse outcomes in older people. Several tools are recommended to assess muscle mass, muscle strength and physical performance, but are not always available in daily practice.Objective: The aim of the present study is to evaluate if there is a correlation between the personal perception of physical performance (assessed through a question on personal functional status) and the effective presence of sarcopenia (according to the EWGSOP2 definition) using data from the Longevity Check-up 7+ project.Design: Cross-sectional study.Setting: The Longevity Check-up 7+ project is an ongoing study started in June 2015 and conducted in unconventional settings (i.e., exhibitions, malls, and health promotion campaigns). Subjects: Candidate participants are eligible for enrollment if they are at least 18 years of age and provide written informed consent. For the present study subjects 65 years age old and older have been considered (n=2901).Methods: According to the most recent EWGSOP2 consensus definition, subjects were defined to be affected by probable sarcopenia when handgrip strength was less than 27kg in male and less than 16kg in female, respectively. Furthermore, a single question assessed the perceived health status regarding own physical performance: “Do you have any difficulty in walking 400 meters?”.Results: Using the EWGSOP2 algorithm, 529 (18,9%) participants were identified as affected by probable sarcopenia with a significant higher prevalence among subjects with self-reported difficulty in walking 400 meters compared to participant without any difficulty (33.6% versus 13.1%, respectively; p<0.001). Relative to participants without self-reported difficulty, those subjects with self-reported difficulty in walking 400 meters showed a significantly higher risk of sarcopenia (odds ratio [OR]: 3.34; 95% confidence interval [CI]: 2.75-4.07)Conclusions: A single “Red Flag” question such as “Do you have any difficulty in walking 400 meters?” should be considered as a recommended method for screening probable sarcopenia risk.

show abstract

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Cited by 37 publications

References 80 publications

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Self-reported difficulty in walking 400 meters: the “red flag” for probable sarcopenia

Self-reported Difficulty in Walking 400 Meters: the “red Flag” for Probable Sarcopenia

Contact Info

Product

Resources

About