Sarcopenic obesity: A new challenge in the clinical practice

Ciudin, Andreea; Simó-Servat, Andreu; Palmas, F.; Barahona, María José

doi:10.1016/j.endien.2020.03.007

Cited by 16 publications

(38 citation statements)

References 61 publications

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“…SO is affected by the following conditions: (a) insulin resistance conditions the adipose tissue in the body, (b) chronic inflammation and lipotoxicity has a negative effect of the bone, (c) mitochondrial dysfunction and oxidative stress negatively influence the skeletal muscle, (d) and factors such as age, inadequate diet and sedentary lifestyle have a direct impact on the SO. Relevant and demonstrated associations of SO and other comorbidities apply to diabetes type II and cognitive impairment [6,7]. These comorbidities are also found in our study population.…”

Section: Discussionsupporting

confidence: 80%

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Identification of Sarcopenic Obesity in German Nursing Home Residents—The Role of Body Composition and Malnutrition in the BaSAlt Cohort-Study

et al. 2021

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Background: Sarcopenic obesity (SO) is a phenotype, which is defined by reduced muscle strength, muscle mass, and obesity. Limited mobility leads to increased sedentary behavior and decreased physical activity. Both sarcopenia and obesity are aggravated by these factors. In combination, SO is an additional challenge for the setting nursing home (NH). Previous studies have shown a low prevalence of residents with SO in comparable settings, such as community-dwelling. We hypothesize that the BaSAlt cohort also has a small proportion of residents with SO. Methods: For the analysis, 66 residents (women: 74.2%) aged ≥ 65 years from NH, were screened for SO based on EWGSOP2 specifications and cut-off values to classify obesity. Results: Severe sarcopenia was quantified in eleven residents (16.7%). The majority of sarcopenic residents were women (n = 10) compared to men (n = 1). However, no SO could be identified by assessment of body mass index, fat mass in percentage, and fat mass index. Conclusion: As expected, the setting-specific cohort showed a low number of SO. Furthermore, no case of SO was identified in our study. Sarcopenia was associated with an increased fat-free mass in NH residents. Nevertheless, sarcopenia and obesity play important roles in the preservation of residents’ health.

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Section: Discussionsupporting

confidence: 80%

“…The phenotype is characterized by the presence of sarcopenia as well as obesity [4,5]. The negative effects on physical functioning, morbidity, and mortality are aggravated by their interaction [6]. Studies show different ways to diagnose and treat SO, but there is no consensus [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

Identification of Sarcopenic Obesity in German Nursing Home Residents—The Role of Body Composition and Malnutrition in the BaSAlt Cohort-Study

et al. 2021

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“…80,81 Co-existence of sarcopenia and obesity (i.e., sarcopenic obesity) is considered even more harmful, since the negative effects of low SMM and high fat mass may potentiate each other. 82 For this reason, it would be valuable to include clinical outcomes, such as physical rehabilitation, muscle strength, and muscle function to determine the impact of bariatric surgery on long-term health.…”

Section: Discussionmentioning

confidence: 99%

The magnitude and progress of lean body mass, fat‐free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta‐analysis

Nuijten¹,

Eijsvogels²,

Monpellier

et al. 2021

Obesity Reviews

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Postbariatric loss of muscle tissue could negatively affect long-term health due to its role in various bodily processes, such as metabolism and functional capacity. This meta-analysis aimed to unravel time-dependent changes in the magnitude and progress of lean body mass (LBM), fat-free mass (FFM), and skeletal muscle mass (SMM) loss following bariatric surgery. A systematic literature search was conducted in Pubmed, Embase, and Web of Science. Fifty-nine studies assessed LBM (n = 37), FFM (n = 20), or SMM (n = 3) preoperatively and ≥1 time points postsurgery. Random-effects meta-analyses were performed to determine pooled loss per outcome parameter and follow-up time point. At 12-month postsurgery, pooled LBM loss was À8.13 kg [95%CI À9.01; À7.26]. FFM loss and SMM loss were À8.23 kg [95%CI À10.74; À5.73] and À3.18 kg [95%CI À5.64; À0.71], respectively. About 55% of 12-month LBM loss occurred within 3-month postsurgery, followed by a more gradual decrease up to 12 months. Similar patterns were seen for FFM and SMM. In conclusion, >8 kg of LBM and FFM loss was observed within 1-year postsurgery. LBM, FFM, and SMM were predominantly lost within 3-month postsurgery, highlighting that interventions to mitigate such losses should be implemented perioperatively.

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“…31 It is essential to identify sarcopenic obesity due to its association with several comorbidities: increased insulin resistance, diabetes, cardiovascular disease, metabolic syndrome, dyslipidemia, arterial hypertension, stress, suicidal ideation, knee osteoarthritis, reduced coordination, or aerobic capacity, osteoporosis, and fractures, among others. 2,3,6,28,39,40 In a meta-analysis of cohort studies, Tian and Xu 41 showed that sarcopenic obesity increased all-cause mortality.…”

Section: Surgical Menopause and Sarcopenic Obesitymentioning

confidence: 99%

“…20,22 Few studies explore the relationship between gynecological conditions and surgeries with sarcopenic obesity, and even several authors have pointed out that the information on this musculoskeletal condition is limited. 2,3,6 Studies on the association between gynecological surgery and sarcopenic obesity in the Latin American population were not identified, nor is there any information on the behavior of surgical menopause concerning sarcopenic obesity in adult Colombian women. The objective of this study was to identify the frequency of clinical suspicion of sarcopenic obesity (CSSO) and probable sarcopenic obesity (PSO) as well as to estimate the association between each of them with a history of surgical menopause, bilateral oophorectomy performed after natural menopause, and abdominal hysterectomy with ovarian preservation.…”

mentioning

confidence: 99%

Clinical suspicion of sarcopenic obesity and probable sarcopenic obesity in Colombian women with a history of surgical menopause: a cross-sectional study

et al. 2022

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Objectives: To identify the frequency of clinical suspicion of sarcopenic obesity (CSSO) and probable sarcopenic obesity (PSO) and to estimate the association between them and surgical menopause.Methods: A cross-sectional study carried out in women residing in Colombia, ages 60 to 75 years. Body mass index, the SARC-F scale, SARC-CalF < 31, and SARC-CalF <33 versions adding the calf circumference measurement in the last two were used to identify CSSO. Muscle strength measurement was added to the above measures to establish PSO. Surgical menopause was defined in women who underwent bilateral oophorectomy simultaneously with hysterectomy before natural menopause. Adjusted and unadjusted logistic regression were performed between CSSO or PSO with surgical menopause, bilateral oophorectomy after natural menopause, and abdominal hysterectomy with ovarian preservation. All participants provided informed consent. P < 0.05 was statistically significant.Results: Seven hundred women 67.0 AE 4.8 years old were included; 23.7% were obese, 68.1% had reduced muscle strength, and 4.2% had surgical menopause. CSSO was found in 3.0% with SARC-F and with SARC-CalF < 31; whereas 2.0% were found with SARC-CalF <33. PSO was found in 2.4%, 1.5%, and 2.2% with SARC-F, SARC-CalF <31, and SARC-CalF <33, respectively. Surgical menopause was associated with PSO but was not associated with CSSO. Bilateral oophorectomy after menopause and hysterectomy with ovarian preservation were not associated with CSSO or PSO.Conclusions: In a group of older adult women, the frequency of CSSO was up to 3.0% and PSO up to 2.4%. Surgical menopause was statistically significantly associated with PSO. On the contrary, CSSO was not associated.

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Sarcopenic obesity: A new challenge in the clinical practice

Cited by 16 publications

References 61 publications

Identification of Sarcopenic Obesity in German Nursing Home Residents—The Role of Body Composition and Malnutrition in the BaSAlt Cohort-Study

Identification of Sarcopenic Obesity in German Nursing Home Residents—The Role of Body Composition and Malnutrition in the BaSAlt Cohort-Study

The magnitude and progress of lean body mass, fat‐free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta‐analysis

Clinical suspicion of sarcopenic obesity and probable sarcopenic obesity in Colombian women with a history of surgical menopause: a cross-sectional study

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