Sarcopenic obesity is a postoperative prognostic factor for stage II and III colorectal cancer

Mizuno, Shodai; Seishima, Ryo; Okabayashi, Koji; Shigeta, Kohei; Matsui, Shimpei; Kitagawa, Yuko

doi:10.1007/s11605-021-04965-8

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…Our sample exhibited a 9.34% incidence, consistent with results reported in the literature, which range from 6 to 18%[ 2 , 6 ]. Notably, our analysis failed to demonstrate an independent association between sarcopenia, visceral obesity, and postoperative abdominal complications.…”

Section: Discussionsupporting

confidence: 92%

“…SO is associated with an elevated incidence of postoperative complications, prolonged hospital stays, and heightened hospitalisation costs [3][4][5][6]. This study aims to examine the correlation between preoperative CT measures of SO and short-term surgical outcomes within a relatively homogeneous group of non-metastatic colon cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Bajawi,

Corral,

Blázquez

et al. 2024

Langenbecks Arch Surg

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Objective This study aimed to investigate the influence of sarcopenic obesity on anastomotic leak following elective colon resection for non-metastatic colon cancer. Secondary outcomes included overall morbidity, mortality and length of hospital stay. Methods This retrospective observational study, conducted at a colorectal surgery referral centre, spanned from January 1, 2015, to January 1, 2020. A total of 544 consecutive patients who underwent elective colon resection were included in the analysis, excluding patients with rectal cancer, urgent surgery, absence of anastomosis, lack of imaging, multivisceral resections and synchronic tumours. Results Postoperative complications were observed in 177 (32.3%) patients, with 51 (9.31%) classified as severe (Clavien-Dindo > II). Sarcopenic obesity was identified in 9.39% of the sample and emerged as an independent predictor of increased overall morbidity [OR 2.15 (1.14–3.69); p = 0.016] and 30-day mortality [OR 5.07 (1.22–20.93); p = 0.03] and was significantly associated with the development of anastomotic leak [OR 2.95 (1.41–6.18); p = 0.007]. Furthermore, it increased the risk of reoperation and was linked to a prolonged length of hospital stay. Conclusions CT-measured sarcopenic obesity demonstrates a discernible correlation with an elevated risk of postoperative morbidity and mortality in the context of colon cancer surgery.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Bajawi,

Corral,

Blázquez

et al. 2024

Langenbecks Arch Surg

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“…Patients with low SMI-to-BMI ratio is associated with a condition having high BMI and low SMI. This condition is in accordance with the concept of sarcopenic obesity, which has recently gained considerable attention as a superior marker to sarcopenia for predicting the prognosis and postoperative complications in patients with cancer [17][18][19][20]. To evaluate the impact of sarcopenic obesity, we strati ed the patients into four groups (high-SMI/low-BMI, high-SMI/high-BMI, low-SMI/low-BMI, and low-SMI/high-BMI).…”

Section: Impact Of Sarcopenic Obesity As Risk Factor Postsurgicalsupporting

confidence: 59%

Skeletal muscle index-to-body mass index ratio as a predictor of postsurgical bleeding after mastectomy in patients with breast cancer

Morikawa

Oba

Kiyosawa

et al. 2023

Preprint

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Background Postsurgical bleeding is a major complication of mastectomy in patients with breast cancer. However, the risk factors for postsurgical bleeding have not been well studied. Although obesity or reduced skeletal muscle mass is an indicator of cancer surgery complications, its impact on postsurgical bleeding after mastectomy remains unknown.Methods In total, 563 patients with breast cancer who underwent mastectomy were included in this study. We evaluated the preoperative body mass index (BMI), skeletal muscle index (SMI), and SMI-to-BMI ratio and analyzed the association between these values and the incidence of postsurgical bleeding.Results Postsurgical bleeding occurred in 33 (5.6%) patients. Mean BMI was significantly higher in the bleeding group (26.3 ± 4.7) than in the no bleeding group (23.0 ± 4.1) (p < 0.001), whereas mean SMI was lower in the former group (45.0 ± 8.5) than in the latter group (48.0 ± 8.5) (p = 0.08). The bleeding group had significantly lower SMI-to-BMI ratio (1.71 ± 0.16) than the no bleeding group (2.10 ± 0.23) (p < 0.001). Among these three parameters, SMI-to-BMI ratio had the highest area under the curve value in their receiver operating characteristic curves (0.73 for BMI, 0.59 for SMI, 0.92 for SMI-to-BMI ratio). Furthermore, on multivariate analysis, SMI-to-BMI ratio was an independent risk factor for postsurgical bleeding (hazard ratio, 38.4; 95% confidence interval, 13.9–136.2; p < 0.001).Conclusions SMI-to-BMI ratio is a superior predictive factor of postsurgical bleeding after mastectomy to either BMI or SMI alone.

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“…Hamaguchi et al 22 reported the validity of applying PMI to define sarcopenia in Asian populations, and accumulating numbers of reports have shown its validity as an indicator of sarcopenia and have shown the association with colorectal cancer prognosis. [23][24][25][26][27] Based on such evidence, PMI was applied as an indicator of sarcopenia in this Asian population study. The total psoas muscle area was identified and quantified in HU using the OsiriX DICOM Viewer (Pixmeo SARL, Switzerland) to measure pixels with a window width of -30 to 150 HU to delineate the muscle compartments and compute the cross-sectional area of each in centimeters squared (cm 2 ).…”

Section: Definition Of Sarcopeniamentioning

confidence: 99%

The Prognostic Impact of Preoperative Osteopenia in Patients with Colorectal Cancer

Kato,

Seishima,

Mizuno

et al. 2023

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Osteopenia, a condition in which bone mineral density is lower than normal, is a noted risk factor that leads to a shortened healthy life expectancy. OBJECTIVE: This study aimed to investigate the prognostic impact of preoperative osteopenia in colorectal cancer patients. DESIGN: This was a retrospective study. SETTING: This study was conducted at a university hospital. PATIENTS: A total of 1,086 stage I-III colorectal cancer patients who underwent curative resection. MAIN OUTCOME MEASURES: Osteopenia was evaluated with computed tomography imaging. Overall survival, disease-specific survival, and recurrence-free survival were the primary endpoints. RESULTS: Osteopenia was identified in 300 patients (27.6%). Compared with the non-osteopenia group, the 5-year overall survival (74.0% vs. 93.4%, p < 0.001), disease-specific survival (81.6% vs. 97.2%, p < 0.001), and recurrence-free survival rates (57.1% vs. 88.3%, p < 0.001) were significantly lower in the osteopenia group. Multivariate analyses showed that preoperative osteopenia was significantly associated with worse overall survival (HR: 4.135; 95% CI: 2.963-5.770; p < 0.001), disease-specific survival (HR: 7.673; 95% CI: 4.646-12.675; p < 0.001), and recurrence-free survival (HR: 5.039; 95% CI: 3.811-6.662; p < 0.001). The prognosis of the osteopenia group was poorer than that of the non-osteopenia group in every stage: 5-year overall survival (stage I: 89.4% vs. 96.9%, p = 0.028; stage II: 76.5% vs. 91.9%, p < 0.001; stage III: 56.4% vs. 90.8%, p < 0.001) and 5-year RFS (stage I: 85.4% vs. 96.6%, p = 0.002; stage II: 62.0% vs. 86.5%, p < 0.001; stage III: 26.4% vs. 80.0%, p < 0.001). LIMITATIONS: The main limitations are retrospective single-institutional feature, and races of study population. CONCLUSION: Preoperative osteopenia could be a strong predictive marker for long-term prognosis in colorectal cancer regardless of stage.

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Sarcopenic obesity is a postoperative prognostic factor for stage II and III colorectal cancer

Cited by 13 publications

References 5 publications

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Skeletal muscle index-to-body mass index ratio as a predictor of postsurgical bleeding after mastectomy in patients with breast cancer

The Prognostic Impact of Preoperative Osteopenia in Patients with Colorectal Cancer

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