Sarcopenic Obesity Tendency and Nutritional Status Is Related to the Risk of Sarcopenia, Frailty, Depression and Quality of Life in Patients with Dementia

Chou, Hsi-Hsien; Lai, Te-Jen; Yen, Chi-Hua; Chang, Po-Sheng; Pan, Ji-Cyun; Lin, Ping-Ting

doi:10.3390/ijerph19052492

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…In the study, in which 36 patients were included and sarcopenic obesity was evaluated with DEXA measurements, sarcopenic obesity was observed in 5 female patients 47 . The prevalence of sarcopenic obesity was found to be 58.3%, although, unlike our study, the sarcopenic obesity prevalence in the mild and moderate dementia groups was similar 48 …”

Section: Discussioncontrasting

confidence: 72%

Prevalence of nutrition disorders and nutrition‐related conditions in older patients with Alzheimer's disease

et al. 2023

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BackgroundsAlzheimer's disease is frequently encountered with nutrition‐related conditions such as malnutrition, sarcopenia, frailty, overnutrition, and micronutrient abnormalities in older patients. In this study, we aimed to evaluate the prevalence of nutrition disorders and nutrition‐related conditions in the same patient group.MethodsA total of 253 older patients with Alzheimer's disease underwent comprehensive geriatric assessment, which included nutrition‐related disorders, malnutrition via the Mini Nutritional Assessment‐Short Form (MNA‐SF), frailty via the Clinical Frailty Scale (CFS), and sarcopenia was diagnosed according to European Working Group on Sarcopenia in Older People‐2 criteria.ResultsThe patients' mean age was 79.8 ± 6.5 years, and 58.1% were women. In our patients, 64.8% had malnutrition or were at risk of malnutrition; 38.3% had sarcopenia; 19.8% were prefrail; and 80.2% were frail. Malnutrition, frailty, and sarcopenia prevalence increased as the Alzheimer's disease stage progressed. Malnutrition was found to be significantly related with frailty scores via CFS (odds ratio [OR], 1.397; P = 0.0049) and muscle mass via fat‐free mass index (FFMI) (OR, 0.793; P = 0.001). In logistic regression analysis, age, MNA‐SF, and CFS were included in the model to detect the independent correlates of probable and confirmed sarcopenia. CFS was independently associated with probable and confirmed sarcopenia (OR, 1.822; P = 0.013; OR, 2.671; P = 0.001, respectively). Frailty was similarly related with FFMI (OR, 0.836; P = 0.031). Obesity was independently related with FFMI (OR, 0.688; P < 0.001).ConclusionIn conclusion, nutrition disorders and nutrition‐related conditions can present concurrently in patients with all stages of Alzheimer's disease; therefore, these frequent problems should be screened and diagnosed accordingly.

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Section: Discussioncontrasting

confidence: 72%

Prevalence of nutrition disorders and nutrition‐related conditions in older patients with Alzheimer's disease

et al. 2023

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“…Recent data suggest that preserving muscular mass (with a larger calf circumference) and avoiding central obesity might help prevent functional impairment even in centenarians (Stern, 2002 ). Similar to sarcopenia, SO has been linked to frailty and osteoporosis (Fan et al, 2021 ; Chou et al, 2022 ). Moreover, individuals with SO are at greater risk of metabolic disorders and reduced physical performance, such as walking speed, than those with sarcopenia or obesity alone (Sun et al, 2021 ; Tan et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to some previous reports, the prevalence of SO in Chinese community-dwelling older adults was estimated at 6.0–25.0% (Chang et al, 2016 ; Chen et al, 2021 ; Cheng et al, 2022 ). SO is associated with poor health outcomes including frailty, disability (Choe et al, 2018 ), fractures, falls (Chou et al, 2022 ), cancer (Daviglus et al, 2010 ), cardiometabolic diseases (Donini et al, 2020 ), chronic kidney disease (Dye et al, 2017 ), and increased mortality (Espeland et al, 2022 ). Those who suffer from this geriatric syndrome are at risk of synergistic complications that can eventually result in long-term functional decline.…”

Section: Introductionmentioning

confidence: 99%

Waist-to-calf circumstance ratio and cognitive function among Chinese older adults: Mediating roles of physical performance and social activity

Cao

Yang

Zhou

2023

Front. Aging Neurosci.

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BackgroundIn light of the potentially detrimental effects of central fat and decreased muscle mass on cognitive function, it would be beneficial to learn more about the mediating mechanisms underpinning the association between the two. The purpose of this study is to determine the association between waist-to-calf circumstance ratio (WCR) and cognitive function, as well as to investigate whether physical performance and social activity mediate the relationship between WCR and cognitive function among older Chinese adults.MethodsAn analysis of 9,652 older Chinese adults was conducted during the 2018 wave of the Chinese Longitudinal Health Longevity Survey (CLHLS). The Mini-Mental State Examination (MMSE) and a self-reported scale were used to measure cognitive function, physical performance, and social activity, respectively. Multiple linear regression and mediation analyses were conducted.ResultsThe findings suggest that a high WCR had a significant negative association with cognitive function (B = −0.535, 95% CI: −0.754, −0.317). Mediation analysis revealed that a high WCR influenced old adults' cognitive function in three ways: first, through the partial mediating effect of physical performance (B = −0.270; 95% CI: −0.340, −0.203); second, through the partial mediating effect of social activity (B = −0.035; 95% CI: −0.055, −0.017); and third, through the serial mediating effects of physical performance and social activity (B = −0.021, 95% CI: −0.029, −0.015).ConclusionThe study results suggest the adverse impact of a high WCR on older adults' cognitive function, and the possible mechanisms of physical performance and social activity by which the association takes place. Multidimensional health and social interventions aimed at improving physical, social, and cognitive functioning among older adults with sarcopenic obesity are recommended.

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“…Depression significantly increases the risk of cardiovascular disease in older adults, according to a recent prospective cohort study ( Yu et al, 2022 ). In addition, a study of people with dementia found that the risk of malnutrition was significantly associated with muscle function and the risk of sarcopenia, frailty, depression, as well as reduced quality of life in people with dementia ( Chou et al, 2022 ). Moreover, the results of a large cross-sectional study of malnutrition in older patients with obesity using the Comprehensive Geriatric Assessment suggested that malnutrition in patients with obesity is associated with depression ( Soysal et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between Comprehensive Geriatric Assessment parameters and depression in elderly patients

Liu

Zhang

et al. 2022

Front. Aging Neurosci.

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BackgroundDepression is common and serious among elderly patients. The treatment of elderly depression is often delayed owing to insufficient diagnosis, which eventually leads to adverse consequences.AimsTo explore the association between the parameters of the Comprehensive Geriatric Assessment and depression in elderly patients.MethodsA cross-sectional study of 211 outpatients and inpatients aged ≥ 65 years from the Comprehensive Geriatric Assessment database was conducted. A Comprehensive Geriatric Assessment inventory was prepared by compiling and screening general characteristics, chronic diseases (cardiovascular disease, diabetes, and peptic ulcer disease), nutritional status, daily living ability, anthropometric measurements (body mass index (BMI), upper arm circumference, and calf circumference), and blood biochemical indicators (hemoglobin, albumin, prealbumin, triglycerides, and low-density lipoprotein cholesterol). The Geriatric Depression Scale was also conducted for each elderly patient to screen for depression. A multivariable logistic regression analysis was used to determine the association between the parameters of the Comprehensive Geriatric Assessment and geriatric depression.ResultsThere were 63 patients in the depression group with a median age of 84.00 years, and 148 patients in the non-depression group with a median age of 78.50 years. After controlling for confounders, the risk of depression in elderly patients with cardiovascular diseases was 6.011 times higher than that in those without cardiovascular diseases (p < 0.001); and the risk of depression in elderly patients with peptic ulcer diseases was 4.352 times higher than that in those without peptic ulcer diseases (p < 0.001); the risk of depression in elderly patients decreased by 22.6% for each 1-point increase in the Mini Nutritional Assessment (p < 0.001). The risk of depression in elderly patients decreased by 19.9% for each 1-point increase in calf circumference (p = 0.002), and by 13.0% for each 1-point increase in albumin (p = 0.014).ConclusionOur findings suggest that Comprehensive Geriatric Assessment parameters, such as cardiovascular disease, peptic ulcer disease, Mini Nutritional Assessment score, calf circumference, and albumin, were associated with depression. The Comprehensive Geriatric Assessment can assist in the early identification of depression in the elderly population.

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Sarcopenic Obesity Tendency and Nutritional Status Is Related to the Risk of Sarcopenia, Frailty, Depression and Quality of Life in Patients with Dementia

Cited by 9 publications

References 40 publications

Prevalence of nutrition disorders and nutrition‐related conditions in older patients with Alzheimer's disease

Prevalence of nutrition disorders and nutrition‐related conditions in older patients with Alzheimer's disease

Waist-to-calf circumstance ratio and cognitive function among Chinese older adults: Mediating roles of physical performance and social activity

The relationship between Comprehensive Geriatric Assessment parameters and depression in elderly patients

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