Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats

Otani, Lila; Ninomiya, Toshiaki; Murakami, Megumi; Osajima, Katsuhiro; Kato, Harubumi; Murakami, Tetsuo

doi:10.1271/bbb.90311

Cited by 43 publications

(20 citation statements)

References 48 publications

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“…ACE activity. ACE activity was determined by the modified method of Otani et al, 24) using an Hip-His-Leu synthetic substrate (SigmaAldrich, St. Louis, MO, USA). Briefly, each plasma sample (10 mL) that had been prepared by immediately centrifuging the blood sample at 2;000 Â g for 20 min at 4 C was incubated for 30 min at 37 C with 5 mM Hip-His-Leu in 40 mL of a 200 mM borate buffer (pH 8.3) containing 400 mM NaCl.…”

Section: Methodsmentioning

confidence: 99%

Antihypertensive Effect of Boysenberry Seed Polyphenols on Spontaneously Hypertensive Rats and Identification of Orally Absorbable Proanthocyanidins with Vasorelaxant Activity

Furuuchi

Sakai

Hirokawa

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Methodsmentioning

confidence: 99%

Antihypertensive Effect of Boysenberry Seed Polyphenols on Spontaneously Hypertensive Rats and Identification of Orally Absorbable Proanthocyanidins with Vasorelaxant Activity

Furuuchi

Sakai

Hirokawa

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Lactotripeptide from fermented milk, 2) dodecapeptide from casein, 3) a group of peptides from sardines, 4) -aminobutyric acid from soybean, 5) and acetic acid in vinegar 6) have all been found to have antihypertensive effects, and are claimed to be suitable for people with moderately high blood pressure in Japan. 7) Proanthocyanidins (PAs), also called condensed tannins, have attracted considerable attention due to their potential health-promoting benefits though reported antihypertensive, antioxidative, and anticarcinogenic effects.…”

mentioning

confidence: 99%

Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats

Kawakami

Aketa

Sakai

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…In this regards, Otani and colleagues (2009) used the stroke-prone SHR, a wellcharacterized animal model of essential hypertension with high incidence of stroke, cardiac hypertrophy, kidney dysfunction and hyperglycemia, to investigate the effects of a Sardinederived ACE-I peptide (SP) exhibiting an ACE inhibitory concentration of IC 50 value of 62.4 µg/ml, on blood glucose level and blood pressure (Otani et al, 2009). SP-ACE inhibitor-treated animals showed i) a decreased ACE activity in the kidney, aorta and mesentery and lowered BP;…”

Section: Anti-obesity Peptidesmentioning

confidence: 99%

A Review of Potential Marine-derived Hypotensive and Anti-obesity Peptides

Manikkam

Vasiljevic

Donkor

et al. 2015

Critical Reviews in Food Science and Nutrition

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Bioactive peptides are food derived components, usually consisting of 3-20 amino acids, which are inactive when incorporated within their parent protein. Once liberated by enzymatic or chemical hydrolysis, during food processing and gastrointestinal transit, they can potentially provide an array of health benefits to the human body. Owing to an unprecedented increase in the worldwide incidence of obesity and hypertension, medical researchers are focusing on the hypotensive and anti-obesity properties of nutritionally derived bioactive peptides. The role of the renin-angiotensin system has long been established in the aetiology of metabolic diseases and hypertension. Targeting the renin-angiotensin system by inhibiting the activity of angiotensin-converting enzyme (ACE) and preventing the formation of angiotensin II can be a potential therapeutic approach to the treatment of hypertension and obesity. Fish-derived proteins and peptides can potentially be excellent sources of bioactive components, mainly as a source of ACE inhibitors. However, increased use of marine sources, poses an unsustainable burden on particular fish stocks, so, the underutilized fish species and by-products can be exploited for this purpose. This paper provides an overview of the techniques involved in the production, isolation, purification, and characterization of bioactive peptides from marine sources, as well as the evaluation of the ACE inhibitory (ACE-I) activity and bioavailability.

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Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats

Cited by 43 publications

References 48 publications

Antihypertensive Effect of Boysenberry Seed Polyphenols on Spontaneously Hypertensive Rats and Identification of Orally Absorbable Proanthocyanidins with Vasorelaxant Activity

Antihypertensive Effect of Boysenberry Seed Polyphenols on Spontaneously Hypertensive Rats and Identification of Orally Absorbable Proanthocyanidins with Vasorelaxant Activity

Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats

A Review of Potential Marine-derived Hypotensive and Anti-obesity Peptides

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