Sargassum filipendula, a Source of Bioactive Compounds with Antioxidant and Matrix Metalloproteinases Inhibition Activities In Vitro with Potential Dermocosmetic Application

Abstract

The antioxidant and the potential inhibitory capacity of matrix metalloproteinases of the phlorotannin-type polyphenolic and fucoidan-type polysaccharides extracts obtained from the macroalga S. filipendula were evaluated. Through chromatographic and spectroscopic techniques, the corresponding chemical structure of compounds present in the extracts was determined. Antioxidant capacity was evaluated using the methyl linoleate model for the inhibition of lipid peroxidation, and the free radical scavenging capacity was assessed using DPPH, ABTS, •OH, O2•− methods. The matrix metalloproteinase inhibition potential was measured by collagenase and elastase inhibition tests, using epigallocatechin gallate as a positive control. The extracts exhibited a high scavenging capacity of radical species evaluated and inhibition of diene conjugate formation and thiobarbituric acid reactive substances. The results showed that the crude extracts presented dose-dependent collagenase and elastase inhibition, with IC50 values between 0.04 and 1.61 mg/mL. The structure of the residues of the polysaccharide was identified mainly as (1→3)-sulfated (1→3) α-l-fucopyranose at carbon 4 and residues of β-d-glucopyranose, α-d-Mannopyranose, and β-d-Galactopyranose, while in the polyphenol extract the presence of phloroglucinol was identified and the presence of eckol, bifuhalol, and trifuhalol was suggested. Our results allow us to infer that S. filipendula is a potential source of bioactive ingredients with antioxidant and anti-aging activity.

The Effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors

“…However, there was significantly higher sulphation levels and glycosidic bonds and lower uronic acid content in crude extract from F. vesiculosus compared to all other fucoidans, which may explain the differences in the mechanisms of action of this particular fucoidan. These results are a confirmation of our previous findings where weight percentages of glucose, fucose, sulphated sugars and uronic acid were measured [16,31]. A higher sulphation and lower uronic acid contents have been associated with high anticoagulant capacity [32], suggesting that the crude extract from F. vesiculosus may have clinical relevance as an anti-coagulant agent.…”

Innovative Eco-Friendly Microwave-Assisted Rapid Biosynthesis of Ag/AgCl-NPs Coated with Algae Bloom Extract as Multi-Functional Biomaterials with Non-Toxic Effects on Normal Human Cells

“…Additionally, Sargassum serves as an abundant source of bioactive compounds with diverse applications in pharmaceuticals and nutraceuticals. These bioactive compounds encompass antioxidants, anti-inflammatory agents, and antimicrobial substances, which offer exciting prospects for the development of novel drugs, functional foods, and dietary supplements [ 5 , 6 ]. Therefore, harnessing the potential of these compounds derived from Sargassum opens up avenues for advancements in healthcare and nutrition.…”