Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042

Abstract

Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.

Marine natural products

“…These metabolites were all C-4 epimers based on the julichrome Q 10 184 skeleton. 59 Analysis of various Streptomyces ferments afforded chlorinated 3-phenylpropanoic acid derivatives 188–190 , 60 MMP-1 secretion inhibitor sarmentosamide 191 , 61 a new anti-MRSA tetracene derivative, mersaquinone 192 , 62 hexacyclic xanthone ukixanthomycin A 193 , 63 butenolide mycenolide A 194 , 64 22-membered macrolides 195–197 , 65 angucycline derivatives, monacyclinones G–K 198–202 and ent -gephyromycin A 203 (ref. 66) and chromomycin A9 204 , which showed potent activity towards several microbial strains.…”

Exploring the Potential of Using Marine-Derived Ingredients: From the Extraction to Cutting-Edge Cosmetics

“…In a similar manner, fucoidan, like other sulfated polysaccharides, not only inhibits the production of MMP-1 mRNA through the ERK pathway when fibroblasts are induced with UVB radiation, but also increases the expression of type I procollagen synthesis [13,16]. Also, through the inhibition of the ERK/JNK pathway, Streptomyces sp.derived sarmentosamide is another promising anti-aging agent that reduces the expression of UVB-induced MMP-1 in normal human dermal fibroblasts [30]. Sargachromanol E, present in the extract of brown macroalgae Sargassum horneri, activates tissue inhibitors of metalloproteinase 1 (TIMP-1) and 2 (TIMP-2), inhibiting MMP expression more effectively than retinoic acid [2,16].…”