Sarmentosumols A to F, New Mono- and Dimeric Alkenylphenols from Piper sarmentosum

Abstract

Two new mono- and four new dimeric alkenylphenols, namely sarmentosumols A to F (1-6), were isolated from the aerial parts of Piper sarmentosum. The structures of these compounds were determined through a detailed analysis of NMR and MS data. Their antimicrobial activity against Escherichia coli, Staphyloccocus aureus, and Candida albicans, and their cytotoxic activity against human myeloid leukemia (K562) and human lung adenocarcinoma (A549) cell lines were also evaluated. Except for sarmentosumol A (1), whose MIC on S. aureus was reported to be 7.0 µg/mL, none of the other newly discovered compounds exhibited antimicrobial property. The studied compounds did not possess any cytotoxic property.

Potato wound-healing tissues: A rich source of natural antioxidant molecules with potential for food preservation

“…The fragment aglycone was isolated from Ganoderma lucidum (Munehisa et al, 1986). Another compound present in F6 was the alkylphenol, Sarmentosumol F, designated as 4-(2 Z )-2-decen-1-yl-5-[1-(4-hydroxyphenyl)decyl]-1,2-benzenediol (Yang et al, 2013) (Table 2, Compound 5 ). As mentioned above, the presence of a catechol group and an adjacent phenolic group can explain the free-radical-scavenging ability of the compound and its possible contribution to the antioxidant activity of the extract.…”

“…This compound, isolated for the first time in the plant Piper sarmentosum , has been reported to possess antimicrobial activity against Escherichia coli, Staphylococcus aureus and Candida albicans microbial species. In addition, this compound demonstrated cytotoxicity against human myeloid leukaemia and in two human lung adenocarcinoma cell lines (Yang et al, 2013). All isolated components in fraction 6 were identified.…”

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

“…[9454647] Thirty-two compounds (1-32) have been reported to exhibit cytotoxic activity toward at least one tumor cell line with an IC 50 value less than 4 μg/ml [Table 3]. These compounds include amide alkaloids (1-17), a lignan (18), alkenylphenols (19-22), chalcones and dihydrochalcones (25-27), piperolides (28-31), and other chemical classifications.…”

“…For example, nearly 30 out of 60 indigenous Chinese Piper species are used medically. [345678] Our recent ethnobotanical and medicinal chemistry research focused on Piper plants led to the discovery of cytotoxic amides from Piper boehmeriifolium Wall.,[891011] an anticancer medicine used in India. [12] In China, Piper plants are also used in some formulae to treat cancers.…”

New amide alkaloids from Piper longum fruits

“…17 In addition to amide alkaloids, phytochemicals present also include prenylated phenolic compounds 18 and aromatic esters 19 are found in the plant. In our continuing research on bioactive constituents of Piper species, [20][21][22] three new amide alkaloids piperlongumamides A-C (1-3), along with 12 previously identified ones ( Figure 1) were isolated from the fruits of P. longum. The structural elucidation of the new compounds and the bioassay results are reported.…”