SARS-CoV-2: A potential trigger of dermato-neuro syndrome in a patient with scleromyxedema

Dermato-neuro Syndrome after COVID-19 Vaccination in a Patient with Scleromyxoedema Previously Controlled with Bortezomib and Intravenous Immunoglobulins

“…To our knowledge, this is the first reported case of DNS secondary to SARS-CoV-2 vaccination. Two patients with SMX who developed DNS following SARS-CoV-2 infection have been reported recently ( 3 , 14 ). Both of these patients responded to plasmaphereses, while IVIG were ineffective.…”

“…Both of these patients responded to plasmaphereses, while IVIG were ineffective. Fritz et al ( 14 ) speculated that recent infections that elicit a hyper-inflammatory states may increase the risk of developing DNS, in the same way as recent infection or vaccination is suspected to favour exacerbations in multiple sclerosis ( 15 ). The current case supports their hypothesis.…”

Dermato‐neuro syndrome after COVID‐19 infection in a patient with scleromyxoedema: Previously successful treatment with intravenous immunoglobulins

“…9 The production and release of the proinflammatory cytokine IL-6 increases during viral infections such as influenza A or SARS-CoV-2. IgG levels in the cerebral microvasculature may rise as a result of increased blood-brain barrier 3 recently reported the first case of a patient with SMX who experienced a DNS attack after infection with influenza A and SARS-CoV-2. Anguelova et al 12 also recently reported on two patients with SMX who developed DNS after infection with the influenza A virus.…”

“…Most patients have monoclonal gammopathy, with IgG entry being the most common and IgG K being rarer. SMX can also lead to multisystem disease and has a mortality rate of approximately 20% 3 . The pathophysiologic mechanism underlying DNS is unknown; however, elevated levels of vasoactive cytokines have been reported in cases of DNS.…”

“…SMX can also lead to multisystem disease and has a mortality rate of approximately 20%. 3 The pathophysiologic mechanism underlying DNS is unknown; however, elevated levels of vasoactive cytokines have been reported in cases of DNS. Increased blood-brain barrier permeability may elevate IgG levels in the cerebral microvasculature in monoclonal gammopathy, leading to hyperviscosity and sludge.…”