SARS-CoV-2: A Promising Path in Salivary Diagnosis

Fernandes, Larissa Leci; Borges, Leandro; Pacheco, Valeria Bordallo; Bernardes, Alessandra; Ribeiro, Rafaela Rosa; Jiménez, Manuel E.; Heller, Débora

doi:10.2174/1874210602014010343

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…Caution is needed to define which people would advantage from suppressing the neutrophil response and which would help more from a strengthened neutrophil action during viral infections. Despite prior studies linking pulmonary diseases to aberrant NET formation [ 3,4 ] , our understanding of NETosis mechanisms in viral infection is still limited.…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

“…This virus can cross species barriers and induce illnesses ranging from the usual cold to severe interstitial pneumonia, respiratory failure, and septic shock [1]. While there is a global effort in the development of vaccines and improvement of diagnostic methods [2,3] and therapies that relieve the symptoms and prognosis of COVID-19 patients under severe infection [4], there remain gaps in our understanding of the pathophysiology of COVID-19 related to innate immunity.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Borges

Pithon-Curi

Curi

et al. 2020

Mediators of Inflammation

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191

152

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Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. Neutrophils play a critical function in the clearance of bacteria with specific mechanisms to combat viruses. The aim of this review is to highlight the current advances in the pathways of neutrophilic inflammation against viral infection over the past ten years, focusing on the production of neutrophil extracellular traps (NETs) and its impact on severe lung diseases, such as COVID-19. We focused on studies regarding hyperinflammation, cytokine storms, neutrophil function, and viral infections. We discuss how the neutrophil’s role could influence COVID-19 symptoms in the interaction between hyperinflammation (overproduction of NETs and cytokines) and the clearance function of neutrophils to eliminate the viral infection. We also propose a more in-depth investigation into the neutrophil response mechanism targeting NETosis in the different phases of COVID-19.

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Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Borges

Pithon-Curi

Curi

et al. 2020

Mediators of Inflammation

Self Cite

191

152

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“…Thus, thinking about the function and importance of schools for the intellectual and social development of children, the re-opening must be done safely. For this reason, large-scale testing using saliva 24 can be a viable alternative to ensure testing of all children and school staff before and during the re-opening of the schools. Hence, depending on the child's age and level of understanding about the pandemic, complying with safety rules can be complicated.…”

Section: Severe Pneumoniamentioning

confidence: 99%

Saliva: an important alternative for screening and monitoring of COVID-19 in children

et al. 2020

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The increasing number of cases of COVID-19 worldwide poses challenges to healthcare systems not only in effectively identifying individuals positive for SARS-CoV-2, but also in isolating cases to minimise contagion in early diagnosing more severe cases that will need hospitalization. Less-invasive collection methods are indispensable in a pandemic scenario as large-scale tests are necessary to understand the actual evolution of contagion in different populations, thus enabling decision-making based on scientific evidence. Saliva has been shown to be an alternative for diagnosing viral infections as this biological fluid can be easily and quickly collected without using specific devices and causing less discomfort during collection, which is an important factor for use in children. Despite the smaller percentage of severe cases of COVID-19 among children, they seem to play an important role in the contagion as they have the same potential of transmission as that of adults. Knowing the evolution of COVID-19 pandemic in children is extremely important, mainly regarding the changing in rules of social distancing, such as reopening schools and recreational activities spaces. In addition, countless cases of a severe multi-systemic inflammatory syndrome that shares clinical and laboratory features with Kawasaki's disease have been recently related to SARS-CoV-2 infections in children, adolescents and young adults. In view of this scenario, the aim of this study was to present saliva as an alternative for seeking diagnostic and prognostic markers of COVID-19 in children, including adequate sample collection techniques for different age groups.

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SARS-CoV-2: A Promising Path in Salivary Diagnosis

Cited by 2 publications

References 12 publications

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Saliva: an important alternative for screening and monitoring of COVID-19 in children

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