SARS‐CoV‐2 acute bronchiolitis in hospitalized children: Neither frequent nor more severe

Andina-Martínez, David; Cadenas, José Antonio Alonso; Cobos‐Carrascosa, Elena; Bodegas, Inmaculada; Oltra-Benavent, Manuel; Plazaola, Ane; Epalza, Cristina; Jiménez-García, Raquel; Moraleda, Cinta; Tagarro, Alfredo

doi:10.1002/ppul.25731

Cited by 24 publications

(22 citation statements)

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“…No other viruses were isolated for that patient. Recently, a multicenter study of children hospitalized with SARS-CoV-2 [ 25 ], concludes that SARS-CoV-2 infection does not seem to be a main trigger of severe bronchiolitis, and that children with this condition should be managed following the clinical practice guidelines.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis, epidemiological changes during the SARS-CoV-2 pandemic

et al. 2022

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Background Bronchiolitis is the most common viral infection of the lower respiratory tract in infants under 2 years of age. The aim of this study was to analyze and compare the seasonal bronchiolitis peaks before and during the SARS-CoV-2 pandemic. Methods Descriptive, prospective, and observational study. Patients with severe bronchiolitis admitted to the Pediatric Intensive Care Unit (PICU) of a referral tertiary hospital between September 2010 and June 2021 were included. Demographic data were collected. Viral laboratory-confirmation was carried out. Each season was analyzed and compared. The daily average temperature was collected. Results 1116 patients were recruited, 58.2% of them males. The median age was 49 days. Respiratory syncytial virus (RSV) was isolated in 782 cases (70.1%). In April 2021, the first and only case of bronchiolitis caused by SARS-CoV-2 was identified. The pre- and post-pandemic periods were compared. There were statistically significant differences regarding: age, 47 vs. 73 days (p = 0.006), PICU and hospital length of stay (p = 0.024 and p = 0.001, respectively), and etiology (p = 0.031). The peak for bronchiolitis in 2020 was non-existent before week 52. A delayed peak was seen around week 26/2021. The mean temperature during the epidemic peak was 10ºC for the years of the last decade and is 23ºC for the present season. Conclusion The COVID-19 pandemic outbreak has led to a clearly observable epidemiological change regarding acute bronchiolitis, which should be studied in detail. The influence of the environmental temperature does not seem to determine the viral circulation.

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Section: Discussionmentioning

confidence: 99%

Bronchiolitis, epidemiological changes during the SARS-CoV-2 pandemic

et al. 2022

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“…This is a very prevalent issue as 63-88% of positive blood culture obtained from infants less than 90 days old are contaminated. [23][24][25] This could be a burden for the family and the health care system as it may result in unnecessary admission, investigations, use of antibiotics, and prolong the length of stay. 12 Study limitations.…”

Section: Resultsmentioning

confidence: 99%

The prevalence of serious bacterial infections in infants 90 days and younger with viral respiratory tract infections

Almojali

Alshareef

Aljadoa

et al. 2022

SMJ

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Objectives: To determine the prevalence and risk factors of serious bacterial infections (SBIs) in infants 90 days and younger with a confirmed respiratory tract infection (RTI). Methods:A retrospective cross-sectional study was carried out of infants 90 days and younger who were admitted to King Abdullah Specialized Children's Hospital, Riyadh, Saudi Arabia, from January 2019 to December 2020, with polymerase chain reaction (PCR)-proven RTI. Cultures from the urine, blood, and cerebrospinal fluid were reviewed with the patients' demographic information and clinical presentation. Original ArticleResults: Of 322 patients with a viral RTI, 21 (6.5%) had a concurrent urinary tract infection (UTI), and no patients had bacteremia or bacterial meningitis. The risk of a concurrent SBI was 4 times higher in neonates (odds ratio [OR]=4.66, 95% confidence interval [CI]: [1. 32-16.47]). Previously healthy infants were at lower risk to have a SBI in comparison to those with chronic diseases or renal abnormalities (OR=0.23, 95% CI: [0.09-0.61]). In addition, male gender (OR=3.49, 95% CI: [1. 07-11.38]) and abnormal urinalysis (OR=4.12, 95% CI: [1. 48-11.42]) were predictors of SBIs. There was no statistically significant association between the number or type of detected viruses and SBIs. Conclusion:No cases of invasive bacterial infections were found in infants with PCR-proven viral RTIs. There is a risk of having a concurrent UTI in this cohort of patients. Neonates had a higher risk of UTIs as compared to older infants.

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“…There are several possible reasons for these findings. While viral bronchiolitis may be associated with COVID-19, the frequency may be rare [ 19 , 20 ]. Children may be less likely to develop critical illness or concerning symptoms (i.e.…”

Section: Discussionmentioning

confidence: 99%