SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells

Szpulak, Angelika; Garlak, Urszula; Ćwirko, Hanna; Witkowska, Bogusława; Rombel‐Bryzek, Agnieszka; Witkowska, Danuta

doi:10.1016/j.csbj.2023.01.024

Cited by 6 publications

(5 citation statements)

References 98 publications

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“…SARS-CoV-2 viral infections not only causes respiratory damage, but may also have serious effects on the male patients' reproductive system which regulate many physiological processes. Even though it appears that erectile function deteriorates after COVID-19 infection, the function tends to improve over time [26] Patients with COVID-19 have a high risk and prevalence of ED, which may be driven primarily by anxiety, and attention should be paid to patients' erectile function when treating COVID-19 [27]. Some researchers have also characterized the histopathology of tissue from patients who recovered from symptomatic COVID-19 infection, finding that the COVID-19 virus is present in the penis long after the initial infection in human [28].…”

Section: Discussionmentioning

confidence: 99%

Evaluating male sexual function and reproductive health during Omicron outbreak in China: A cross-sectional study

Chen,

Xiao,

Liu

et al. 2023

Preprint

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Our aim was to estimate changes in sexual function and semen quality in men recovering from infection since the Omicron pandemic started in China in late 2022. We collected 1540 questionnaires and assessed male function before infection and acute phase after infection by using International Index of Erectile Function-5, Premature Ejaculation Diagnostic Tool, and Arizona Sexual Experience Scale. We also collected the before and after semen analysis results of 247 male patients. During the acute phase after infection, the proportion of erectile dysfunction was significantly higher than before infection, but ejaculatory function was not significantly altered； In addition, semen analysis showed significant difference in semen concentration, semen activity and PR a+b sperm forward movement after infection compared to pre-infection. Omicron can affect erectile function as well as sexual experience in male patients in the acute phase. The risk factors for decreased sexual function due to Omicron included body temperature and anxiety during infection.

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Section: Discussionmentioning

confidence: 99%

Evaluating male sexual function and reproductive health during Omicron outbreak in China: A cross-sectional study

Chen,

Xiao,

Liu

et al. 2023

Preprint

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“…SARS-CoV-2, the virus responsible for COVID-19, primarily affects the respiratory system, but it can indeed have significant impacts on other organs in the body [33]. One of the most concerning effects is its potential to cause damage to the heart.…”

Section: Other Organsmentioning

confidence: 99%

Comprehensive Review of COVID-19: Symptoms, Diagnosis, and Management

2024

austinjautismrelatdisabil

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COVID-19, caused by the novel coronavirus SARS-CoV-2, can lead to a wide range of symptoms, varying from mild to severe. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include fatigue, muscle or body aches, headache, loss of taste or smell, sore throat, congestion or runny nose, nausea or vomiting, and diarrhea. Some individuals may also experience more severe symptoms such as difficulty breathing, chest pain or pressure, confusion, inability to stay awake, and bluish lips or face, which require immediate medical attention. It’s important to note that symptoms can appear 2-14 days after exposure to the virus, and some individuals may remain asymptomatic carriers. If you suspect you have COVID-19 or have been exposed to the virus, it’s crucial to seek medical advice and follow public health guidelines to prevent the spread of the virus. COVID-19 diagnosis involves identifying the presence of the SARS-CoV-2 virus through various methods such as RT-PCR testing, antigen testing, antibody testing, and imaging techniques such as chest X-rays and CT scans. Early and accurate diagnosis is crucial for effective management and control of the disease. Rapid and widespread testing, along with proper isolation and contact tracing, are essential for containing the spread of the virus. COVID-19 management involves a multifaceted approach, including vaccination, testing, contact tracing, and public health measures such as mask-wearing and social distancing. Treatment focuses on supportive care and, in some cases, antiviral medications. On-going research is crucial for developing effective strategies to control the spread of the virus and mitigate its impact on public health.

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“…Compared with the lung, the digestive organs have higher ACE2 expression levels [19]. These findings indicated that in addition to intestinal inflammation caused by the systemic inflammatory response due to SARS-CoV-2, the virus may also directly affect the digestive system by attacking intestinal cells [20].…”

Section: Introductionmentioning

confidence: 97%

Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19

Xiong

Yang

et al. 2023

CIMB

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Digestive system cancer and COVID-19 significantly affect the digestive system, but the mechanism of interaction between COVID-19 and the digestive system cancers has not been fully elucidated. We downloaded the gene expression of COVID-19 and seven digestive system cancers (oral, esophageal, gastric, colorectal, hepatocellular, bile duct, pancreatic) from GEO and identified hub differentially expressed genes. Multiple verifications, diagnostic efficacy, prognostic analysis, functional enrichment and related transcription factors of hub genes were explored. We identified 23 common DEGs for subsequent analysis. CytoHubba identified nine hub genes (CCNA2, CCNB1, CDKN3, ECT2, KIF14, KIF20A, KIF4A, NEK2, TTK). TCGA and GEO data validated the expression and excellent diagnostic and prognostic ability of hub genes. Functional analysis revealed that the processes of cell division and the cell cycle were essential in COVID-19 and digestive system cancers. Furthermore, six related transcription factors (E2F1, E2F3, E2F4, MYC, TP53, YBX1) were involved in hub gene regulation. Via in vitro experiments, CCNA2, CCNB1, and MYC expression was verified in 25 colorectal cancer tissue pairs. Our study revealed the key biomarks and common pathogenesis of digestive system cancers and COVID-19. These may provide new ideas for further mechanistic research.

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SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells

Cited by 6 publications

References 98 publications

Evaluating male sexual function and reproductive health during Omicron outbreak in China: A cross-sectional study

Evaluating male sexual function and reproductive health during Omicron outbreak in China: A cross-sectional study

Comprehensive Review of COVID-19: Symptoms, Diagnosis, and Management

Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19

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