SARS-CoV-2 and Orientia tsutsugamushi co-infection in a young teen, Nepal: Significant burden in limited-resource countries in Asia?

Bastola, Anup; Sah, Ranjit; Rajbhandari, Sagar Kumar; Jha, Runa; Fathah, Zareena; Chalise, Bimal Sharma; Shrestha, B; Shah, Ritesh; Balla, Pujan; Nepal, Richa; Adhikari, Bipin; Rabaan, Ali A.; Dhama, Kuldeep; Rodríguez‐Morales, Alfonso J.

doi:10.52225/narraj.v1i2.34

Cited by 10 publications

(9 citation statements)

References 11 publications

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“…The age was not a significant risk factor for coinfection in one study by Kim et al [ 16 ]. Less frequently recognized pathogens were shown in some cohorts including Mycoplasma pneumoniae , Orientia tsutsugamushi and dengue virus [ 18 – 20 ]. These pathogens may reflect the local endemicity of diseases and can be underestimated by laboratories that do not routinely perform molecular and serological detection.…”

Section: Introductionmentioning

confidence: 99%

Bacterial and Fungal Coinfection in Critically Ill COVID-19 Cases and Predictive Role of Procalcitonin During the First Wave at an Academic Health Center

Alnimr

Alshahrani

Alwarthan

et al. 2022

J Epidemiol Glob Health

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Background Coinfection at various sites can complicate the clinical course of coronavirus disease of 2019 (COVID-19) patients leading to worse prognosis and increased mortality. We aimed to investigate the occurrence of coinfection in critically ill COVID-19 cases, and the predictive role of routinely tested biomarkers on admission for mortality. Methods This is a retrospective study of all SARS-CoV-2-infected cases, who were admitted to King Fahad Hospital of the University between March 2020 and December 2020. We reviewed the data in the electronic charts in the healthcare information management system including initial presentation, clinical course, radiological and laboratory findings and reported all significant microbiological cultures that indicated antimicrobial therapy. The mortality data were reviewed for severely ill patients who were admitted to critical care units. Results Of 1091 admitted patients, there were 70 fatalities (6.4%). 182 COVID-19 persons were admitted to the critical care service, of whom 114 patients (62.6%) survived. The in-hospital mortality was 13.4%. Coinfection was noted in 67/68 non-survivors, and Gram-negative pathogens (Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumanni) represented more than 50% of the etiological agents. We noted that the serum procalcitonin on admission was higher for non-survivors (Median = 1.6 ng/mL ± 4.7) than in survivors (Median = 0.2 ng/mL ± 4.2) (p ≤ 0.05). Conclusion Coinfection is a serious complication for COVID-19 especially in the presence of co-morbidities. High levels of procalcitonin on admission may predict non-survival in critically ill cases in whom bacterial or fungal co-infection is likely.

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Section: Introductionmentioning

confidence: 99%

Bacterial and Fungal Coinfection in Critically Ill COVID-19 Cases and Predictive Role of Procalcitonin During the First Wave at an Academic Health Center

Alnimr

Alshahrani

Alwarthan

et al. 2022

J Epidemiol Glob Health

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“…3,4 A syndemic of COVID-19 and other endemic infections could be particularly burdensome to tropical countries. 5,6 In the present scenario, strict adherence to social distancing (maintaining a physical distance of at least 2 meters), wearing a face mask, and regular handwashing are essential practices that are highly recommended for preventing human-to-human transmission of SARS-CoV-2. 7,8 Social distancing plays a critical role in slowing the rapid transmission of SARS-CoV-2 within the community.…”

Section: Introductionmentioning

confidence: 99%

Beliefs on social distancing and face mask practices during the COVID-19 pandemic in low- and middle-income countries: a cross-sectional study

et al. 2022

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Introduction: Social distancing and wearing a face mask are highly recommended to mitigate the transmission of coronavirus disease 2019 (COVID-19). However, the success of these strategies relies on individuals’ adherence and public compliance. This study was conducted to assess the level of belief in social distancing and face mask practices in communities in low- and middle-income countries (LMICs) and to identify their possible determinants. Methods: A cross-sectional study was conducted in ten LMICs countries in Asia, Africa, and South America from February to May 2021. A questionnaire was used to assess the belief, practice, and their plausible determinants. Identification of the associated determinants was performed using a logistic regression model. Results: Our data revealed that only 62.6% and 66.9% of the participants had good beliefs in social distancing and good face mask practices, respectively. Residing in the Americas, having a healthcare-related job, knowing people in immediate social environment who are or have been infected and exposure to information of COVID-19 cases on social media or TV were factors significantly associated with good belief in social distancing. Residing country, gender, monthly household income, type of job and exposure to information of COVID-19 cases were significantly associated with face mask wearing practice. Conclusion: The proportion of participants having good beliefs in social distancing and good face mask practices is relatively low (<75%). Hence, sustained health campaigns regarding social distancing benefits and face mask-wearing practices during COVID-19 are critical in LMICs.

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“…3,4 In addition, coinfection of SARS-CoV-2 and endemic infections in Asia is a major concern. 5,6 As of June 30, 2021, 259,301 people in Thailand had been infected with COVID-19, and there were 2,023 deaths. 7 The most vulnerable group in the infected population was older people.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with COVID-19 Vaccine Hesitancy in Thai Seniors

Thanapluetiwong¹,

Chansirikarnjana²,

Sriwannopas³

et al. 2021

PPA

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SARS-CoV-2 and Orientia tsutsugamushi co-infection in a young teen, Nepal: Significant burden in limited-resource countries in Asia?

Cited by 10 publications

References 11 publications

Bacterial and Fungal Coinfection in Critically Ill COVID-19 Cases and Predictive Role of Procalcitonin During the First Wave at an Academic Health Center

Bacterial and Fungal Coinfection in Critically Ill COVID-19 Cases and Predictive Role of Procalcitonin During the First Wave at an Academic Health Center

Beliefs on social distancing and face mask practices during the COVID-19 pandemic in low- and middle-income countries: a cross-sectional study

Factors associated with COVID-19 Vaccine Hesitancy in Thai Seniors

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