SARS-CoV-2 antibody response eight months after vaccination with mRNA vaccines. Influence of prior SARS-CoV-2 exposure

García-Cruces-Méndez, Jesús Fernando; Corral‐Gudino, Luis; Del-Amo-Merino, María Piedad; Eirós-Bouza, José María; González, Marta Domínguez-Gil

doi:10.1016/j.ejim.2022.01.011

Cited by 8 publications

(9 citation statements)

References 10 publications

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Section: Discussionmentioning

confidence: 99%

“…Individuals with hybrid immunity have been shown to exhibit the highest (neutralizing) antibody levels and the best protection against reinfection ( 8 , 37 – 39 ). This is already apparent in the first weeks after vaccination and persists up to 8 months ( 8 , 37 – 39 ). Individuals with hybrid immunity have higher peak antibody levels and a slower decline over time up to 10 months ( 33 , 33 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

“…The waning of vaccine-induced immunity has been attributed to declining anti-S antibody levels and the emergence of variants of concern (VOC). Anti-S antibody levels start to decline 2-3 months after vaccination, declining continuously up to 8 months after vaccination ( 6 – 8 ). A similar continuous decline has been observed for anti-S and anti-N antibodies after natural infection ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

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IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers

et al. 2022

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BackgroundIgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and protection against (re)infection.MethodsWe measured IgG anti-S and surrogate neutralizing antibody kinetics against Wild Type (WT) and 4 Variants of Concern (VOC) in health care workers (HCW) 3 and 10 months after natural infection (“infection”, n=83) or vaccination (2 doses of BNT162b2) with (“hybrid immunity”, n=17) or without prior SARS-CoV-2 infection (“vaccination”, n=97).ResultsThe humoral immune response in the “vaccination” cohort was higher at 3 months, but lower at 10 months, compared to the “infection” cohort due to a faster decline. The “hybrid immunity” cohort had the highest antibody levels at 3 and 10 months with a slower decline compared to the “vaccination” cohort. Surrogate neutralizing antibody levels (expressed as %inhibition of ACE-2 binding) showed a linear relation with log10 of IgG anti-S against WT and four VOC. IgG anti-S corresponding to 90% inhibition ranged from 489 BAU/mL for WT to 1756 BAU/mL for Beta variant. Broad pseudoneutralization predicted live virus neutralization of Omicron BA.1 in 20 randomly selected high titer samples.ConclusionsHybrid immunity resulted in the strongest humoral immune response. Antibodies induced by natural infection decreased more slowly than after vaccination, resulting in higher antibody levels at 10 months compared to vaccinated HCW without prior infection. There was a linear relationship between surrogate neutralizing activity and log10 IgG anti-S for WT and 4 VOC, although some VOC showed reduced sensitivity to pseudoneutralization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers

et al. 2022

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“…VACCICOVAO cohort study was intended to analyze the evolution of the COVID-19 pandemic in vaccinated health professionals. The methodology of the cohort was previously described [4] . In summary, the Hospital Universitario Rio Hortega (HURH) conducted a vaccination campaign of all health care workers between January and March 2021.…”

mentioning

confidence: 99%

The Omicron wave and the waning of COVID-19 vaccine effectiveness. Influence of vaccine booster and age on confirmed infection incidence

Corral‐Gudino

Del-Amo-Merino

Eirós-Bouza

et al. 2022

European Journal of Internal Medicine

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“…in a seminal article published in this journal [11] . On the other hand, SARS-CoV-2 serology would also enable to delay vaccine administration in those with higher and/or persistently elevated humoral response (i.e., previously infected individuals, displaying more durable immune response), who could safely avoid unnecessary boosters, or selecting the most appropriate vaccine formulation, since different vaccines (even constructed with the same principle, i.e., viral mRNA delivery) elicit different types and titers of SARS-CoV-2 antibodies [12] …”

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confidence: 99%

Clinical pearls and pitfalls of SARS-CoV-2 serology

Lippi

Henry

2023

European Journal of Internal Medicine

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SARS-CoV-2 antibody response eight months after vaccination with mRNA vaccines. Influence of prior SARS-CoV-2 exposure

Cited by 8 publications

References 10 publications

IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers

IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers

The Omicron wave and the waning of COVID-19 vaccine effectiveness. Influence of vaccine booster and age on confirmed infection incidence

Clinical pearls and pitfalls of SARS-CoV-2 serology

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