SARS-CoV-2 antibody seroprevalence and associated risk factors in an urban district in Cameroon

Nwosu, Kenechukwu David; Fokam, Joseph; Wanda, Franck; Mama, Lucien; Orel, Erol; Ray, Nicolas; Meke, Jeanine; Tassegning, Armel; Takou, Désiré; Mimbe, Eric; Stoll, Béat; Guillebert, Josselin; Comte, Éric; Keiser, Olivia; Ciaffi, Laura

doi:10.1038/s41467-021-25946-0

Cited by 49 publications

(56 citation statements)

References 32 publications

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“…Despite their importance, differences in detection kits can complicate comparison of seroprevalence data from different parts of the continent. Nwosu et al [ 131 ] reported an antibody seroprevalence of up to 30% from sampling over 900 persons in Yaounde district, Cameroon, and this was more than 300 times the reported national case count from PCR testing. A study in Ghana with rapid kit detection of anti-nucleocapsid protein IgG and IgM reported up to 27% antibody seropositivity in populated areas such as lorry stations and markets, as compared to 10% seropositivity in shopping malls mostly patronized by the affluent [ 132 ], and these are much more than the reported infection rate from national case counts.…”

Section: Covid-19 Seroepidemiology In Africa and The Effect Of Co-inf...mentioning

confidence: 99%

The COVID-19 pandemic in the African continent

Bwire

Ario²,

Eyu³

et al. 2022

BMC Med

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In December 2019, a new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and associated disease, coronavirus disease 2019 (COVID-19), was identified in China. This virus spread quickly and in March, 2020, it was declared a pandemic. Scientists predicted the worst scenario to occur in Africa since it was the least developed of the continents in terms of human development index, lagged behind others in achievement of the United Nations sustainable development goals (SDGs), has inadequate resources for provision of social services, and has many fragile states. In addition, there were relatively few research reporting findings on COVID-19 in Africa. On the contrary, the more developed countries reported higher disease incidences and mortality rates. However, for Africa, the earlier predictions and modelling into COVID-19 incidence and mortality did not fit into the reality. Therefore, the main objective of this forum is to bring together infectious diseases and public health experts to give an overview of COVID-19 in Africa and share their thoughts and opinions on why Africa behaved the way it did. Furthermore, the experts highlight what needs to be done to support Africa to consolidate the status quo and overcome the negative effects of COVID-19 so as to accelerate attainment of the SDGs.

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Section: Covid-19 Seroepidemiology In Africa and The Effect Of Co-inf...mentioning

confidence: 99%

The COVID-19 pandemic in the African continent

Bwire

Ario²,

Eyu³

et al. 2022

BMC Med

View full text Add to dashboard Cite

show abstract

“… Overall seroprevalence of SARS-CoV-2 antibodies in Africa [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. …”

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Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis

Hajissa

Islam

Hassan

et al. 2022

IJERPH

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A reliable estimate of SARS-CoV-2-specific antibodies is increasingly important to track the spread of infection and define the true burden of the ongoing COVID-19 pandemic. A systematic review and a meta-analysis were conducted with the objective of estimating the seroprevalence of SARS-CoV-2 infection in Africa. A systematic search of the PubMed, Scopus, Web of Science and Google Scholar electronic databases was conducted. Thirty-five eligible studies were included. Using meta-analysis of proportions, the overall seroprevalence of anti-SARS-CoV-2 antibodies was calculated as 16% (95% CI 13.1–18.9%). Based on antibody isotypes, 14.6% (95% CI 12.2–17.1%) and 11.5% (95% CI 8.7–14.2%) were seropositive for SARS-CoV-2 IgG and IgM, respectively, while 6.6% (95% CI 4.9–8.3%) were tested positive for both IgM and IgG. Healthcare workers (16.3%) had higher seroprevalence than the general population (11.7%), blood donors (7.5%) and pregnant women (5.7%). The finding of this systematic review and meta-analysis (SRMA) may not accurately reflect the true seroprevalence status of SARS-CoV-2 infection in Africa, hence, further seroprevalence studies across Africa are required to assess and monitor the growing COVID-19 burden.

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“…15,22,23 Access to hospital care is limited and varies within and across countries and regions. 24,25 The burden of SARS-CoV-2 infection, including severe disease requiring hospitalization, is underestimated in sub-Saharan Africa [26][27][28] and is potentially more underestimated among children, who are less likely to be evaluated for infection. 15 To address this issue, the present study assessed clinical manifestations, outcomes, and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa.…”

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confidence: 99%

Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries

et al. 2022

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for the African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on Children and Adolescents IMPORTANCE Little is known about COVID-19 outcomes among children and adolescents in sub-Saharan Africa, where preexisting comorbidities are prevalent. OBJECTIVE To assess the clinical outcomes and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa. DESIGN, SETTING, AND PARTICIPANTS This cohort study was a retrospective record review of data from 25 hospitals in the

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SARS-CoV-2 antibody seroprevalence and associated risk factors in an urban district in Cameroon

Cited by 49 publications

References 32 publications

The COVID-19 pandemic in the African continent

The COVID-19 pandemic in the African continent

Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis

Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries

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